ABSTRACT

　　[Purpose] The present study aimed to investigate the effect ofβ-hydroxybutyrate（βHB） elevation via exogenous ketone supplementation on serum erythropoietin（EPO）and hepcidin concentrations in response to endurance exercise in young active women. [Methods] Eight young women （20±1 years） performed two high-intensity interval cycling sessions （8 sets×3 min of cycling at 85% of peak oxygen consumption） followed by supplementation of 25.5gβHB（8.5 g/h, 3 times;βHB trial） or placebo （CON trial）．Both trials were conducted during the early follicular phase （day 1 to day 7 after the onset of menstruation）．Blood samples were taken before exercise, immediately, 30, 60, 120, and 180 min after exercise. Ketone and iron metabolism were assessed from the collected blood samples. [Results] SerumβHB concentrations in the βHB trial were significantly increased from 30 min to 180 min after exercise（p < 0.01 at each time point）， with higherβHB concentrations in theβHB trial compared to the CON trial（p < 0.05 at each time point）．The average blood glucose concentration in theβHB trial was significantly lower than in the CON trial（p = 0.012）．Serum

DECENTE SPORTS SCIENCE Vol.46/The DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE