ABSTRACT

　In the present study, we investigated the role of p62 in exercise-induced adaptation in muscle of experimental autoimmune myositis （EAM） mice, a widely used animal model for polymyositis. C57BL/6J mice were immunized with myosin to induce EAM and subjected to voluntary running exercise for 4 weeks. Voluntary running exercise increased the levels of phospho-p62 and improved endurance performance but not muscle mass and strength in EAM mice. Moreover, EAM was induced in musclespecific p62 knockout and wild-type littermates mice. The induction of EAM resulted in significant decreases in muscle mass, strength, and endurance performance in wildtype and p62 knockout mice, without any difference between genotypes. These results suggest that voluntary running exercise improves endurance performance in EAM mice independent of p62 function.

DECENTE SPORTS SCIENCE Vol.44/The DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE