ABSTRACT

　 Epidemiological studies and animal studies have shown that regular exercise is effective for preventing and improving obesity and diabetes. Melatonin manipulates wide variety of biological processes including circadian rhythms, immune functions, and antioxidant properties. Here, the present study aimed to investigate the effect of daily melatonin administration on exercise training-induced alteration of body and adipose tissue weights, profiles of adipokines, and antioxidant properties om rats. Two experiments were conducted in this study. First, rats were divided into five groups: normal diet- fed plus sedentary, high-fat diet （HFD） -fed plus sedentary, HFD-fed plus melatonin plus sedentary, HFD-fed plus exercise, and HFD-fed plus melatonin plus exercise group. Rats were subjected to treadmill running and/or melatonin （7.5mg/kg body weight, i.p.） for 9 weeks. Second, rats were randomly assigned to a control and sedentary （CS） group, control and voluntary exercise （CV） group, and melatonin and voluntary exercise （MV） group. The exercise rats were subjected in cages equipped with running wheels where voluntary access to physical activity was available at all times for 11 days. After exercise training periods, serum and mature adipocyte isolated from inguinal adipose tissue were analyzed. We showed that body weight and fat mass were lower in exercise with combination with melatonin group than in other groups. The expression of imflammatory adipokines were reduced, where as anti-obesity cytokine, FGF-21 was dramatically enhanced in combined group. Furthermore, the leves of beige adipocyte markers in MV group were significantly higher than CS and CV group. These results suggest that exercise with daily melatonin administration may contribute to effcient control of body mass and adiposity.

DECENTE SPORTS SCIENCE Vol.43/The DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE