Does Glycation Stress Work as an Exercise-Resistance Factor?
【Supercategory：7. DESCENTE SPORTS SCIENCE Subcategory：7.41 Vol.41】
ABSTRACT
In the present study, to clear the possibility of glycation stress as an exercise-resistance factor, we investigated the effect of glycation stress on the molecules related to glucose metabolism and mitochondrial functions following to endurance exercise training in mice and on muscle power changes following resistance training in human. Four-week voluntary exercise training increased the expression levels of GLUT4, PGC1α, and HSP72 in mouse plantaris muscle. On the other hand, these changes were suppressed by the concomitant treatment of methylglyoxal, an inducer of glycation stress. In young male adults, the group in high-glycation stress showed lower leg muscle power output than that in low-glycation stress, but there was no difference between the two groups in the strength-enhancing effect of 12-week resistance training. In conclusion, it is suggested that glycation stress suppresses skeletal muscle adaptations induced by endurance exercise training and does not affect muscle power enhancement induced by resistance training.
DECENTE SPORTS SCIENCE Vol.41/The DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
In the present study, to clear the possibility of glycation stress as an exercise-resistance factor, we investigated the effect of glycation stress on the molecules related to glucose metabolism and mitochondrial functions following to endurance exercise training in mice and on muscle power changes following resistance training in human. Four-week voluntary exercise training increased the expression levels of GLUT4, PGC1α, and HSP72 in mouse plantaris muscle. On the other hand, these changes were suppressed by the concomitant treatment of methylglyoxal, an inducer of glycation stress. In young male adults, the group in high-glycation stress showed lower leg muscle power output than that in low-glycation stress, but there was no difference between the two groups in the strength-enhancing effect of 12-week resistance training. In conclusion, it is suggested that glycation stress suppresses skeletal muscle adaptations induced by endurance exercise training and does not affect muscle power enhancement induced by resistance training.
DECENTE SPORTS SCIENCE Vol.41/The DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
| Researcher | Tatsuro Egawa*1, Mami Fujibayashi*2,Rika Ito*3, Katsumasa Goto*4,Tatsuya Hayashi*5 |
|---|---|
| University or institution | *1*5 Graduate School of Human and Environmental Studies,Kyoto University,*2 Student Affairs Division Sports Support Center,Setsunan University, *3*4 Graduate School of Health Sciences, Toyohashi SOZO University |
Keywords
glycation stress, exercise resistance, GLUT4, PGC1α, methylglyoxal