ABSTRACT

This study examined high-intensity intermittent training （HIIT） as an anti-obesityand anti-diabetes measure, and its effect on brown adipose tissue（ BAT） activity.The study divided 8-week-old male C57BL/6J mice into a high-fat diet group （HFD;n = 8） and a high-fat diet plus HIIT group（ HFD + HIIT; n = 8）．HIIT comprised 15sets of swimming for 20 s, with a 10-s pause between sets, under 16% loading, 4 timesper week, for 8 weeks. After 8 weeks of intervention, maximum number of HIIT untilexhaustion, citrate synthesis （CS）， body weight, individual tissue weight, blood tests（total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-densitylipoprotein cholesterol [HDL-C], glucose, and adiponectin）， and uncoupling protein 1（UCP-1） expression in BAT were measured.　Compared to the HFD group, the HFD + HIIT group had significantly highermaximum number of HIIT until exhaustion, CS activity, and adiponectin, with lower body weight, fat weight, TC, LDL-C, and blood glucose（ P < 0.05）．Although UCP-1expression in the HFD + HIIT group tended to be greater than in the HFD group（ P =0.09）， there was no significant difference between the two groups.　The results suggested that HIIT may be effective in preventing lifestyle-relateddiseases. Further study of BAT activation with exercise is required.

DECENTE SPORTS SCIENCE Vol.40/The DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE