Establishment of Criteria for Sarcopenia Obesity from Various Arteriosclerotic Indices
【Supercategory：7. DESCENTE SPORTS SCIENCE Subcategory：7.39 Vol.39】
ABSTRACT
The aim of this study is to prove how lean mass affect risk factor of arteriosclerosis with sarcopenic obesity. We studied 16 out patients with sarcopenia (Sarco: age; 75.9±5.7years, BMI; 22.1±2.3kg/m²) and 32 obesity (OB: age; 46.0±13.1years, BMI;38.2±4.4kg/m²). All patients underwent dual energy X-ray absorptiometry (DEXA), cardio pulmonary exercise test (CPX), blood test, HOMA-IR, hand grip, walking speed, branchial ankle pulse wave velocity (baPWV) and reactive hyperemia index (RHI). OB group also underwent CT scan in addition to above examinations. Skeletal muscle mass index (SMI) of Sarco group was conformed with Sarcopenia criteria (6.7±0.5kg/m²). On the other hand, OB group has high SMI and muscle strength (9.3±1.0kg/m², 34.4±6.6kg). baPWV, RHI, LDL/HDL ratio (L/H) and TG/HDL ratio (T/H) were evaluated as index of arteriosclerosis. There were no significant differences of those index in 2 groups but RHI, LDL/HDL ratio and TG/HDL ratio were showed high value in OB group. OB patients were divided to 2 groups (HOMAIR low group: HOMA-IR was less than 2.5, HOMA-IR high group: HOMA-IR was more than 2.5) and every data was compared with 2 groups. Lean mass index (SMI, %lean/W, %appendicular aleletal muscle (ASM) /W, lean/fat (Total), VFA/lean) were also assessed with both groups. There were significantly difference with age, peak VO₂, total fat mass, %lean/W, lean/fat (Total), AST, ALT, IRI, and T/H. ROC analysis showed that the cutoff of %lean/W to identify HOMA-IR was 58.6% and lean/fat (Total) was 1.52 with optimal sensitivity (85.7%) and specificity (72.0%). The area under the curve (AUC) of both indexes was 0.789. In conclusion, it was cleared that characteristics and relationship were observed between body composition and arteriosclerosis of highly obese Japanese male patients. We consider that index of lean mass would predict insulin resistance. It also would be one of diagnostic criteria of sarcopenic obesity.
DESCENTE SPORTS SCIENCE Vol.39/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
The aim of this study is to prove how lean mass affect risk factor of arteriosclerosis with sarcopenic obesity. We studied 16 out patients with sarcopenia (Sarco: age; 75.9±5.7years, BMI; 22.1±2.3kg/m²) and 32 obesity (OB: age; 46.0±13.1years, BMI;38.2±4.4kg/m²). All patients underwent dual energy X-ray absorptiometry (DEXA), cardio pulmonary exercise test (CPX), blood test, HOMA-IR, hand grip, walking speed, branchial ankle pulse wave velocity (baPWV) and reactive hyperemia index (RHI). OB group also underwent CT scan in addition to above examinations. Skeletal muscle mass index (SMI) of Sarco group was conformed with Sarcopenia criteria (6.7±0.5kg/m²). On the other hand, OB group has high SMI and muscle strength (9.3±1.0kg/m², 34.4±6.6kg). baPWV, RHI, LDL/HDL ratio (L/H) and TG/HDL ratio (T/H) were evaluated as index of arteriosclerosis. There were no significant differences of those index in 2 groups but RHI, LDL/HDL ratio and TG/HDL ratio were showed high value in OB group. OB patients were divided to 2 groups (HOMAIR low group: HOMA-IR was less than 2.5, HOMA-IR high group: HOMA-IR was more than 2.5) and every data was compared with 2 groups. Lean mass index (SMI, %lean/W, %appendicular aleletal muscle (ASM) /W, lean/fat (Total), VFA/lean) were also assessed with both groups. There were significantly difference with age, peak VO₂, total fat mass, %lean/W, lean/fat (Total), AST, ALT, IRI, and T/H. ROC analysis showed that the cutoff of %lean/W to identify HOMA-IR was 58.6% and lean/fat (Total) was 1.52 with optimal sensitivity (85.7%) and specificity (72.0%). The area under the curve (AUC) of both indexes was 0.789. In conclusion, it was cleared that characteristics and relationship were observed between body composition and arteriosclerosis of highly obese Japanese male patients. We consider that index of lean mass would predict insulin resistance. It also would be one of diagnostic criteria of sarcopenic obesity.
DESCENTE SPORTS SCIENCE Vol.39/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
| Researcher | Nana Takao*1, Yutaka Kimura*1, Hiromi Tsutsumi*2 |
|---|---|
| University or institution | *1 Department of Health Science, Kansai Medical University, Kansai Medical University Hospital Health Science Center, *2 Department of Health Science, Kansai Medical University |
Keywords
sarcopenic obesity, body fat mass, lean body mass, arteriosclerosis, insulin resistance