Does Adiponectin Induce Skeletal Muscle Atrophy? -A Physiological Aspect of Adiponectin Paradox-
【Supercategory：7. DESCENTE SPORTS SCIENCE Subcategory：7.38 Vol.38】
ABSTRACT
The purpose of this study was to investigate the profile of adiponectin expression in slow soleus (SOL) and fast extensor digitorum longus (EDL) muscles of 10-and 100-week old mice, and to evaluate the effects of adiponectin analogue AdipoRon (AR) on myogenesis of C2C12 cells. Age-associated decrease in muscle weight in EDL was higher than that in SOL. Protein expression level of adiponectin in both SOL and EDL was increased by aging. Aging-associated up-regulation of adiponectin in SOL was lower than that in EDL. AR partially suppressed myogenic differentiation of C2C12 cells in a dose-dependent manner. However, AR-associated suppression of myogenesis was partially inhibited by knockdown of adiponectin receptor 1. Evidences suggests that aging-associated up-regulation of skeletal muscle-specific adiponectin may be a cause of sarcopenia, and strongly support “adiponectin paradox” in the regulation of skeletal muscle mass.
DESCENTE SPORTS SCIENCE Vol.38/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
The purpose of this study was to investigate the profile of adiponectin expression in slow soleus (SOL) and fast extensor digitorum longus (EDL) muscles of 10-and 100-week old mice, and to evaluate the effects of adiponectin analogue AdipoRon (AR) on myogenesis of C2C12 cells. Age-associated decrease in muscle weight in EDL was higher than that in SOL. Protein expression level of adiponectin in both SOL and EDL was increased by aging. Aging-associated up-regulation of adiponectin in SOL was lower than that in EDL. AR partially suppressed myogenic differentiation of C2C12 cells in a dose-dependent manner. However, AR-associated suppression of myogenesis was partially inhibited by knockdown of adiponectin receptor 1. Evidences suggests that aging-associated up-regulation of skeletal muscle-specific adiponectin may be a cause of sarcopenia, and strongly support “adiponectin paradox” in the regulation of skeletal muscle mass.
DESCENTE SPORTS SCIENCE Vol.38/THE DESCENTE AND ISHIMOTO MEMORIAL FOUNDATION FOR THE PROMOTION SPORTS SCIENCE
| Researcher | Katsumasa Goto |
|---|---|
| University or institution | Department of Physiology, Graduate School of Health Sciences, Toyohashi SOZO University |
Keywords
sarcopenia, skeletal muscle, adiponectin, adiponectin receptor, cell culture