News&Topics20.10.20
With changes in dietary habits and sedentary lifestyle, liver cancer derived from obesity, metabolic syndrome, and fatty liver has been increasing in Japan. Then, is it possible to prevent liver cancer from fatty liver by reducing the amount of diet? Dr. Fangping Jia, a fourth-year graduate student in the Department of Metabolic Regulation, and a research team of Dr. Naoki Tanaka have elucidated the mechanism by which a 30% dietary restriction (70% amount of normal diet, 70% of the belly) suppresses fatty liver-derived liver tumors in mice. The results have been recently published in the international journal "Liver Cancer".
A 15-month 30% dietary restriction was conducted for HCV core gene transgenic mice, which spontaneously developed insulin resistance and fatty liver. They found that the prevalence of liver tumor development was decreased from 41% to 8%. By reducing diet, cell growth signaling, such as STAT3, STAT5, and ERK, oxidative stress and endoplasmic reticulum stress, inflammatory signaling, and cell senescence were suppressed. Based on the findings in the current study, we demonstrated the rationale for recommending "70% of the belly" to those with fatty liver, non-alcoholic steatohepatitis (NASH), and metabolic syndrome.
In China, there is also a saying "Let's live healthy with a meal of 70%". We would like to recommend the elimination of overeating and gaining too much weight for healthy longevity.
Journal: Liver Cancer 2020;9:529-548
Title: Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice
Author: Fangping Jia, Pan Diao, Xiaojing Wang, Xiao Hu, Takefumi Kimura, Makoto Nakamuta, Ibuki Nakamura, Saki Shirotori, Yoshiko Sato, Kyoji Moriya, Kazuhiko Koike, Frank J. Gonzalez, Jun Nakayama, Toshifumi Aoyama, Naoki Tanaka* (*corresponding author)
The URL is→ https://www.karger.com/Article/FullText/508308
