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Medicine(Respirology, Infectious Disease, Allergology)

Staff List

Professor HANAOKA Masayuki
Associate Professor YAMAMOTO Hiroshi
Senior Assistant Professor YASUO Masanori, USHIKI Atsuhito
Assistant Professor URUSHIHATA Kazuhisa


E-mail : kokyuki(at)
※ Change (at) to @ when you send an e-mail.

Summary of Activity

Introduction of the department

Our department has made efforts to elucidate the basic and clinical problems in the field of internal medicine, particularly focusing on the respiratory medicine, by means of various research techniques such as case study, epidemiology, molecular and cellular biology, genetic study and also animal studies. The major diseases studied in our department include asthma/COPD (chronic obstructive pulmonary disease), lung cancer/chest malignant tumors, respiratory infectious diseases, interstitial lung diseases, drug-induced lung disease, acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), pulmonary hypertension, sleep apnea syndrome as well as mountain sickness (MS).  MS including high-altitude pulmonary edema (HAPE) mainly occurs in the highland of Shinshu area in Japan.

Research Projects

・The pathophysiology of transition in asthma from childhood to adult.
・The pathophysiology of respiratory airway inflammation in asthma and COPD by using method of inducing sputum from patients.
・The pathophysiology of the airway remolding in chronic asthma and the COPD phenotypes by using HRCT image and IOS method (respiratory airway resistance measurement) and, subsequently, further setup the guideline of treatment therapy.  
・The associations of development of COPD with candidate genes.
・The susceptibility to early onset COPD.
・The clinical characteristics and the genetic pathogenesis of pulmonary fibrosis combined with pulmonary emphysema.
・Pulmonary circulation dynamics during COPD exacerbation.
・The pathophysiology for the development and progression of COPD.
・The effects of different drugs on prevention of COPD by using pulmonary emphysema rat model.
・The mechanisms of mucus production, research of the new drugs, and investigation of the mechanisms in controlling respiratory airway inflammation by using human respiratory airway epithelial cells.

Lung cancer/chest malignant tumors
・Clinical application of ablation catheter under bronchoscope for the treatment of early peripheral lung cancer.
・The research of the new combination therapy with chemotherapy and radiotherapy in the treatment of local advanced non-small-cell lung cancer.
・Participation in national multi-central collaboration in research of advanced thymoma (thymus tumor).
・Investigation of the biochemical characteristics and the treatment effects with respect of thymus tumor and lung cancer.
・Participation in national multi-central cooperation studies.

・Clinical studies of interventional pulmonology.

Respiratory infection
・Seeking the optimal diagnosis criteria and the treatment guideline for pulmonary atypical mycobacteriosis, especially M. avium complex (MAC) disease.
・Epidemiological investigation of time-dependent alterations of resistant bacterium in the field of respiratory infection.

Interstitial lung diseases
・Elucidation of the pathogenesis of hypersensitivity pneumonia caused by Japanese mushrooms, and discussion of the quick diagnosis criteria for this disorder.
・Epidemiological study of drug-induced lung injure and investigation of the molecular genetics of the disorder.  
・Investigation of the clinical characteristics of interstitial pneumonia complicated with collagen diseases, especially amyopathic dermatomyositis.  
・Establishment of the treatment strategy for lung involvements in collagen diseases.
・Clinical application of 123I-metaiodobenzylguanidine (MIBG).

・The research of potential roles for alveolar macrophages in lung injury produced by LPS priming.
・The usefulness of hemodiafiltration and adsorption therapies in the treatment of ALI/ARDS.
・Early intervention of non-invasive ventilation (NIV).

Sleep apnea syndrome (SAS)
・The research of various novel sensors for early diagnosis of SAS.
・Pathophysiology of sleep disorder in high altitude.
・Epidemiological study of the association of obesity-hypoventilation syndrome with metabolic syndrome.
・Elucidation of the associations of development of SAS with candidate genes.

High-altitude medicine
・The molecular genetics in high-altitude pulmonary edema (HAPE).
・The individual susceptibility to HAPE and the mechanisms of development of HAPE.
・The mechanisms regarding genetic adaptation to high altitude in Sherpas.
・The research collaborated with high-altitude medicine institute of Qinghai University, China. .

Drug-induced lung injury
・As principal investigator of “Genetic study with respect to genetic markers in drug-induced lung injury” that is supervised by Ministry of Health, Labour and Welfare of Japan, we are studying the epidemiological investigation of drug-induced lung injure. 

Major Publications

1. Goya H, Kuraishi H, Koyama S, Ichiyama T, Yoshiki F, Hirai K, Agatsuma T, Tateishi K, Kanda S, Yamamoto H, Kubo K, Koizumi T : Phase Ⅰ/Ⅱsutudy of S-1 combined with bitweekly irinotecan chemotherapy in previously treated advanced non-small cell lung cancer.  Cancer Chemother Pharmacol70:691-7 2012

2. Hanaoka M, Ito M, Droma Y, Ushiki A, Kitaguchi Y, Yasuo M, Kubo K : Comparison of gene expression profiling between lung fibrotic and emphysematous tissues sampled from patients with combined pulmonary fibrosis and emphysema.  Fibrogenesis Tissue Repair 5 :17  2012

3. Hanaoka M, Droma Y, Basnyat B, Ito M, Kobayashi N, Katsuyama Y, Kubo K, Ota M : Genetic Variants in EPAS1 Contribute to Adaptation to High-Altitude Hypoxia in Sherpas. PloS One 7 : e50566  2012

4. Ito M, Hanaoka M, Drama Y, Kobayashi N, Yasuo M, Kitaguchi Y, Horiuchi T, Ikegawa K, Katsuyama Y, Kubo K, Ota M : The association of Toll-like receptor 4 gene polymorphisms with the development of emphysema in Japanese subjects: a case control study. BMC Res Notes 5:36 2012

5. Kitaguchi Y, Komatsu Y, Fujimoto K, Hanaoka M, Kubo K : Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma. Int Chron Obstruct Pulmon Dis 7 : 238-239  2012

6. Kitaguchi Y, Taraseviciene-Stewart L, Hanaoka M, Natarajan R, Kraskauskas D, Zoelkel NF : Acrolein Induces Endoplasmic Reticulum Stress and Causes Airspace Enlargement. Plos One7 : e38038  2012

7. Kobayashi T, Koizumi T, Agatsuma T, Yasuo M, tsushima K, Kubo K, Eda S, Kuraishi H, Koyama S, Hachiya T, Ohura N : A phase Ⅱtrial of erlotinib in patients with EGFR wild-type advancrd non-small-cell lung cancer.  Cancer Chemother Pharmacol 69 : 1241-6  2012

8. Komatsu Y, Yamamoto H, Tsushima K, Furuya S, Yoshikawa S, Yasuo M, Kubo K, Yamazski Y, Hasegawa J, Eguchi T, Kondo R, Yoshida K, Koizumi T : Increased Interleukin-8 in Epithelial Lining Fluid of Collapsed Lunds During One-Lung Ventilation for Thpracotomy. Inflammation35 : 1844-50  2012

9. Yamamoto H, Fukushima T, Yokoyama T, Yoshizawa A, Hamano H : Periurethral Involvement of IGg4-Related Disease in an Elderly Woman Mimicking an Enlarged Prostate in Man.  Ann Inter Med157:78-9  2012

10. Yamazaki Y, Ushiki A, Tanabe Y, Koyama S, Kubo K:Antimicrobial and auti-inflammatory effects of clarithromycin on Mycobacterium avium complex replication in cultured human bronchial epithelial cells. J Infect Chemother 18:638-8  2012

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