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Medicine (Cardiovascular)

Staff List

Professor KUWAHARA Koichiro
Associate Professor MOTOKI Hirohiko
Senior Assistant Professor OKADA Ayako, EBISAWA Soichiro
Assistant Professor YAMAZAKI Saeko, MINAMISAWA Masatoshi, MOCHIDOME Tomoaki

Summary of Activity

Cardiovascular diseases such as ischemic heart disease and atherosclerosis are predicted to be the leading cause of death worldwide in the near future; therefore, development of cardiovascular diseases may be an important issue that needs to be studied in the 21st century. The final goal of the research in our laboratory is to define the mechanisms of cardiovascular diseases and development of new therapy for intractable cardiovascular diseases, and contribute to the patients, science, and society.

Research Projects

The current research projects in our laboratory are the following:

1) Clinical research and training of cardiovascular diseases.
2) Role of cytokines and chemokines in the pathophysiology of cardiovascular diseases.
3) Regeneration therapy for cardiovascular diseases using bone marrow stem cells

Major Publications

1. Kashima Y, Takahashi M, Shiba Y, Itano N, Izawa A, Koyama J, Nakayama J, Taniguchi S, Kimata K, Ikeda U. Crucial role of hyaluronan in neointimal formation after vascular injury. PLoS One. 8(3):e58760,2013 

2. Iio K, Sakurai S, Kato T, Nishiyama S, Hata T, Mawatari E, Suzuki C, Takekoshi K, Higuchi K, Aizawa T, Ikeda U. Endomyocardial biopsy in a patient with hemorrhagic pheochromocytoma presenting as inverted Takotsubo cardiomyopathy. Heart Vessels 28(2):255-263,2013

3. Iida O, Yokoi H, Soga Y, Inoue N, Suzuki K, Yokoi Y, Kawasaki D, Zen K, Urasawa K, Shintani Y, Miyamoto A, Hirano K, Miyashita Y, Tsuchiya T, Shinozaki N, Nakamura M, Isshiki T, Hamasaki T, Nanto S; STOP-IC investigators. Cilostazol reduces angiographic restenosis after endovascular therapy for femoropopliteal lesions in the sufficient treatment of peripheral intervention by cilostazol Study. Circulation 127(23) :2307-2315,2013

4. Shiba Y, Fernandes S, Zhu WZ, Filice D, Muskheli V, Kim J, Palpant NJ, Gantz J, Moyes KW, Reinecke H, Van Biber B, Dardas T, Mignone JL, Izawa A, Hanna R, Viswanathan M, Gold JD, Kotlikoff MI, Sarvazyan N, Kay MW, Murry CE, Laflamme MA. hESC-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature 489(7415):322-325,2012

5. Tomita T, Aizawa K, Takeuchi T, Shimada K, Okada A, Koshikawa M, Kasai H, Izawa A, Miyashita Y, Kumazaki S, Koyama J, Ikeda U. Catheter ablation of non-inducible atrial tachycardia after surgical repair of heart disease. Heart Vessels 27(1): 114-118, 2012 

6. Shimada K, Tomita T, Kamijo Y, Higuchi M, Ito K, Koizumi Y, Yamamoto K, Aizawa K, Koshikawa M, Kasai H, Izawa A, Miyashita Y, Kumazaki S, Koyama J, Ikeda U. Hemodialysis-induced P-wave signal-averaged electrocardiogram alterations are indicative of vulnerability to atrial arrhythmias. Citc J 76(3): 612-617, 2012

7. Motoki H, Koyama J, Nakazawa H, Aizawa K, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Takahashi M, Ikeda U. Torsion analysis in the early detection of anthracycline-mediated cardiomyopathy. Eur Heart J Cardiovasc Imaging 13(1):95-103,2012

8. Motoki H, Dahiya A, Bhargava M, Wazni OM, Saliba WI, Marwick TH, Klein AL.Assessment of left atrial mechanics in patients with atrial fibrillation: comparison between two-dimensional speckle-based strain and velocity vector imaging. J Am Soc Echocardiogr 25(4) :428-435,2012

9. Miyashita Y, Saigusa T, Ikeda U.Successful percutaneous flow redirection to the juvenile patient of fulminant myocarditis treated with percutaneous cardio-pulmonary support.Journal of Cardiology Cases 6:e55-e58,2012

10. Motoki H, Borowski AG, Shrestha K, Troughton RW, Tang WH, Thomas JD, Klein AL. Incremental prognostic value of assessing left ventricular myocardial mechanics in patients with chronic systolic heart failure. J Am Coll Cardiol 60(20):2074-2081,2012


GRADUATE
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  • Master's Curriculum Outline
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  • Brain and Sensory Functions
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  • Doctoral Curriculum Outline
  • Join us in Shinshu Med. School, NAGANO
  • Short-term Elective Training for Foreign Medical Students
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  • List of Universities with Partnership Agreements