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Master's Program Human Sciences, Graduate School of Medicine
Doctor's Program Medical Science Division, Department of Medical Science, Graduate School of Medicine, Science and Technology

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Professor TAKAMOTO Masaya


E-mail : masayat(at)
※ Change (at) to @ when you send an e-mail.

Summary of Activity

A chronic inflammation was finding out in recent years to be resulted in cancer, lifestyle-related diseases, a neurodegeneration diseases, autoimmune diseases etc. Using knockout mice, we are exploring the pathogenesis of tumors and autoinflammatory diseases and onset factors.

Research Subject

Relationship between colon cancer onset and intestinal bacteria.
Immunological analysis of autoinflammatory diseases.
Relationship between the function of mucosal sugar chain and infectious disease in developing gastric cancer.

Outlook for Research

Causes of illness are inherited and acquired. Analysis using genetically modified mice has revealed that genetic abnormality is not directly causing carcinogenesis but causes inflammation. Further research will be aimed at leading to the development of new treatments and preventive methods.

Outlook for Students After Graduation

In case of medical doctors, most of the postgraduate students have been back to their own fields.

Major Publications

1. Hu T, Takamoto M, Hida S, Tagawa Y, Sugane K. IFN-gamma deficiency worsen Pneumocystis pneumonia with Th17 development in nude mice.Immunol Lett. 127(1):55-9, 2009.

2. Minegishi Y, Saito M, Nagasawa M, Takada H, Hara T, Tsuchiya S, Agematsu K, Yamada M, Kawamura N, Ariga T, Tsuge I, Karasuyama H. Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome. J Exp Med. 206(6):1291-301, 2009.

3. Masumoto J, Yamazaki T, Ohta K, Nakayama J, Agematsu K. Interleukin-1beta suppression in Blau syndrome: comment on the article by Martin et al. Arthritis Rheum. 60(8):2544-5, 2009.

4. Hida S, Yamasaki S, Sakamoto Y, Takamoto M, Obata K, Takai T, Karasuyama H, Sugane K, Saito T, Taki S Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. Nat Immunol 10(2):214-22, 2009.

5. Yan H, Takamoto M, Sugane K. Exposure to Bisphenol A Prenatally or in Adulthood Promotes TH2 Cytokine Production Associated with Reduction of CD4+CD25+ Regulatory T Cells. Environ Health Perspect. 116(4):514-9, 2008.

6. Nagase H, Jones KM, Anderson CF, Noben-Trauth N. Despite increased CD4+Foxp3+ cells within the infection site, BALB/c IL-4 receptor-deficient mice reveal CD4+Foxp3-negative T cells as a source of IL-10 in Leishmania major susceptibility. J Immunol. 179(4):2435-44, 2007.

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