Parasitology

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Summary of Activity

Zoonosis exists around us, and influences on our health and foods. We aim to conquer the zoonosis, research on the parasite infection as follows is now being carried out.

Research Subject

• ・ New strategy on peptide vaccination therapy of Toxoplasma gondii.
• ・ Defense mechanism against intestinal nematodes.
• ・ Enterobacterial flora and colon cancer.
• ・ Zoonosis

Outlook for Research

Prevention of a severe disease such as congenital toxoplasmosis is a goal of our study.

Major Publications

1. Hu T, Takamoto M, Hida S, Tagawa Y, Sugane K. IFN-gamma deficiency worsen Pneumocystis pneumonia with Th17 development in nude mice.Immunol Lett. 127(1):55-9, 2009.

2. Minegishi Y, Saito M, Nagasawa M, Takada H, Hara T, Tsuchiya S, Agematsu K, Yamada M, Kawamura N, Ariga T, Tsuge I, Karasuyama H. Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome. J Exp Med. 206(6):1291-301, 2009.

3. Masumoto J, Yamazaki T, Ohta K, Nakayama J, Agematsu K.　Interleukin-1beta suppression in Blau syndrome: comment on the article by Martin et al. Arthritis Rheum. 60(8):2544-5, 2009.

4. Hida S, Yamasaki S, Sakamoto Y, Takamoto M, Obata K, Takai T, Karasuyama H, Sugane K, Saito T, Taki S Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. Nat Immunol 10(2):214-22, 2009.

5. Yan H, Takamoto M, Sugane K.　Exposure to Bisphenol A Prenatally or in Adulthood Promotes TH2 Cytokine Production Associated with Reduction of CD4+CD25+ Regulatory T Cells. Environ Health Perspect. 116(4):514-9, 2008.

6. Nagase H, Jones KM, Anderson CF, Noben-Trauth N.　Despite increased CD4+Foxp3+ cells within the infection site, BALB/c IL-4 receptor-deficient mice reveal CD4+Foxp3-negative T cells as a source of IL-10 in Leishmania major susceptibility. J Immunol. 179(4):2435-44, 2007.