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Medicine (Diabetes, Endocrinology and Metabolism)

Staff List

Professor KOMATSU Mitsuhisa
Associate Professor SATO Yoshihiko
Senior Assistant Professor NISHIO Shin-ichi
Assistant Professor SEKIDO Takashi, OIWA Ako, SATO Ai, OHKUBO Yohsuke


E-mail : mitsuk(at)
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Summary of Activity

Principal of our department is to establish newer insights into “Aging and Adaptation” in developing human diseases. In particular, we focus on the researches to elucidate mechanisms by which “Aging and Adaptation” affects endocrine and metabolic disorders. Translation of the basic research findings to clinical application is obviously important tasks for our laboratory. The department has been also contributed to the Shinshu University Hospital as the division of Diabetes, Endocrinology and Metabolism; we aim to perform clinical practice and education of the medical students, young doctors and many other medical specialists.

Research Projects

1)To clarify the mechanism of insulin secretion from pancreatic s-cell, we have been performed series of experiments for over 20 years. We found that glucose stimulates insulin release from the pancreatic s-cell via novel pathway that is now collectively referred to as “KATP chanel-independent pathway. Our current goal of this field is to identify the molecular basis of this pathway and to apply for developing new therapeutic targets for diabetes mellitus.

2)To establish the role of cytosolic binding protein for thyroid hormone (CRYM) and elucidation of possible anti-aging effects of this protein is one of our exciting projects.

3)We interested in a role of estrogen for modulation of autoimmune diseases. In particular, we investigate whether estrogen action is mediated by regulatory T-cells.

4)In order to prevent development of diabetes mellitus, we will examine the effects of exercise and dietary intervention, which we originally developed, on diabetic prone population in collaboration with the department of sports and medical sciences. In addition, we will apply these regimens for the treatment of diabetes mellitus.

5)Clinical trials involving multi-center in Nagano prefecture are on going to evaluate several possible medical intervention for diabetes mellitus.

6)Researches on genetic endocrine disorders such as multiple endocrine neoplasia (MEN) are currently undertaken.

7)By using a bedside artificial pancreas, we examine phathophysiology of diabetes mellitus. We also use the artificial pancreas to control plasma glucose concentration within normal ranges under various conditions in human.

Major Publications

1. Suzuki S, Nishio SI, Takeda T, Komatsu M (2012) Gender-specific regulation of response to thyroid hormone in aging. Thyroid Res 26: 5(1): 1.

2. Suzuki S, Nishio SI, Ishii H, Sato A, Takeda T, Komatsu M (2012) Availability of self-recorded axillary temperature for assessment of thermic effects of food: relationship between HDL-cholesterol level and postprandial thermoregulation in type 2 diabetic patients. Exp Clin Endocrinol Diabetes 120(2): 96-100.

3. Inaba H, Suzuki S, Takeda T, Kobayashi S, Akamizu T, Komatsu M (2012) Amiodarone-induced thyrotoxicosis with thyroid papillary cancer in multinodular goiter: case report. Med Princ Pract 21(2): 190-192.

4. Suzuki S, Shigematsu S, Inaba H, Takei M, Takeda T, Komatsu M (2011) Pituitary resistance to thyroid hormones: pathophysiology and therapeutic options. Endocrine 40(3): 366-371.

5. Ishii H, Sato Y, Takei M, Nishio S, Komatsu M (2011) Glucose-incretin interaction revisited. Endocr J 58: 519-525.

6. Mori J, Sato Y, Ishii H, Komatsu M (2011) Bariatric surgery on type 2 diabetes mellitus patients in Japan. The Shinshu Medical Journal 59: 273-280.

7. Imai H, Ohta K, Yoshida A, Suzuki S, Hashizume K, Usami S, Kikuchi T (2010) mu-crystallin, New candidate protein in endotoxin-induced uveitis. Invest Ophth Vis Sci 51: 3554-3559.

8. Yamazaki M, Sato A, Nishio S, Uehara T, Komatsu M (2010) Transient polyuria related to central diabetes insipidus caused by lymphocytic infundibulo-neurohypophysitis in a patient treated for Graves' disease. Intern Med 49(17): 1885-1890.

9. Yamazaki M, Sato A, Takeda T, Komatsu M (2010) Distinct clinical courses in type 1 diabetes mellitus induced by peg-interferon-alpha treatment for chronic hepatitis C. Intern Med. 49(5): 403-407.

10. Yamazaki M, Kosho T, Kawachi S, Mikoshiba M, Takahashi J, Sano R, Oka R, Yoshida K, Watanabe T, Kato H, Komatsu M, Wakuri K, Knappskog PM, Boman H, Fukushima Y (2010) Cold-induced sweating syndrome with neonatal features of Crisponi syndrome: longitudinal observation of a patient homozygous for a CRLF1 mutation. Am J Med Genet A 152A(3): 764-769.

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