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Orthopaedic Surgery

Staff List

Professor KATO Hiroyuki
Associate Professor TAKAHASHI Jun, HANIU Hisao
Senior Assistant Professor TENSHO Keiji, NAKAMURA Yukio
Assistant Professor HAYASHI Masanori, KURAISHI Shugo

Contact

E-mail : seikei(at)shinshu-u.ac.jp
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Summary of Activity

We investigated physiology, biology, mechanics about bone, cartilage, tendon, ligament, muscle, peripheral nerve, and other motor systems. We have several basic research teams as follows; 1) Carbon nanotube as a biomaterials, 2) Biomechanics of joint and tendon in the elbow and hand, 3) Osteoporosis, 4) Regeneration for cartilage, tendon, and bone, 5) musculoskeletal tumor. We also carry out 6) clinical research regarding rotator cuff injury, baseball elbow, entrapment neuropathy, tendon rupture, spinal deformity, total hip or knee arthroplasty, ACL reconstruction, ankle and foot disorders, musculoskeletal tumor, rheumatoid arthritis. In 2010, there are ten postgraduate students, eight of them are orthopaedic surgeons and two are hand therapists.

Research Projects

1) Carbon nonutube: We mainly perform a research about multi-walled carbon nanotubes(MWCNTs) now. In the medical field, development of new biomaterials using CNTs and their application to clinical practice are expected including applications for cancer treatment such as drug delivery systems and in vivo imaging systems. Use of CNTs in biomaterials applied to bone is anticipated to mainly improve the overall mechanical properties for applications. In our previous report, we performed in vivo studies, to demonstrate that implanted MWCNTs had high compatibility with bone tissues and did not induce bone resorption in the region of implantation in mice. And we showed that MWCNTs inhibit osteoclast differentiation and function. So we hope to develop highly functional biomaterials incorporating CNTs that are optimal for use in bone. The most important concerns for use of CNTs as a biomaterial are whether CNTs are safety. Now we are performing some experiments to solve the problem.

2) Hand biomechanics: Flexor tendon lubrication study has been done to make clear tendon lubrication in various conditions by rabbit tendon model, Thumb, finger, and wrist motion analysis is performed using human volunteers and measured by elecatrical goniometer. We will just start tendon regeneration study from molecular approach.

3) Osteoporsis study: We hypothesize that they necessarily occur asa result of accumulation of some undesirable conditions to the elderly, rather than accidental occurrence due to carelessness. Our prime purpose is to prevent fragility fractures. We try to find the risk factors of serious fragility fractures in elderly before they sustain those fractures, by looking at bone metabolism and biomechanics. This approach may allow us to begin appropriate treatment on appropriate timing for high risk patients. Both clinical and basic research projects are currently underway.

4) Musculoskeletal oncology: Reconstruction of the bone defect by β-TCP with cultured bone marrow stromal cells after curettage in benign bone tumors and tumor-like lesions. Incidence and prevention of deep venous thromboembolism (DVT) after surgery of bone and soft tissue sarcomas in lower extremities.Correlation of the expression of glycosaminoglycans and histological grading in chondrosarcoma.

5) Clinical ortopaedic study: Scoliosis, Spinal reconstruction by using navigator system, cubital tunnel, carpal tunnel, extensor tendon reconstruction, rheumatoid hand and elbow, total hip or knee replacement, ACL reconstruction, rotator cuff repair are analyzed in terms of pathology, treatments, and surgical results.,

Major Publications

1. Haniu H, Matsuda Y, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Okamoto M, Takanashi S, Ishigaki N, Nakamura K, Kato H, Saito N. Toxicoproteomic evaluation of carbon nanomaterials in vitro. J Proteomics. 2012; 74: 2703-12.

2. Yamazaki H, Takeoka M, Kitazawa M, Ehara T, Itano N, Kato H, Taniguchi S. ASC plays a role in the priming phase of the immune response to type II collagen in collagen-induced arthritis. Rheumatol Int. 2012; 32:1625-32.

3. Nakamura Y, He X, Kato H, Wakitani S, Kobayashi T, Watanabe S, Iida A, Tahara H, Warman ML, Watanapokasin R, Postlethwait JH. Sox9 Is Upstream of MicroRNA-140 in Cartilage. Appl Biochem Biotechnol. 2012; 166: 64-71.

4. DeLaurier A, Nakamura Y, Braasch I, Khanna V, Kato H, Wakitani S, Postlethwait JH, Kimmel CB. Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton. BMC Dev Biol. 2012; 12:16.

5. Iwasaki N, Kamishima T, Kato H, Funakoshi T, Minami A. A retrospective evaluation of magnetic resonance imaging effectiveness on capitellar osteochondritis dissecans among overhead athletes. Am J Sports Med. 2012; 40: 624-30.

6. Shiozawa R, Uchiyama S, Sugimoto Y, Ikegami S, Iwasaki N, Kato H. Comparison of splinting versus nonsplinting in the treatment of pediatric trigger finger. J Hand Surg Am. 2012; 37: 1211-6.

7. Narita N, Takao M, Innami K, Kato H, Matsushita T. Minimally invasive subtalar arthrodesis with iliac crest autograft through posterior arthroscopic portals: a technical note. Foot Ankle Int. 2012; 33: 803-5.

8. Itsubo T, Fukushima N, Kakegawa A, Yokouchi K, Kawagishi K, Kato H, Moriizumi T. Effects of repeated crush injuries on motor functional recovery of the sciatic nerve. Neurol Res. 2012; 34: 908-14.

9. Ogihara N, Usui Y, Aoki K, Shimizu M, Narita N, Hara K, Nakamura K, Ishigaki N, Takanashi S, Okamoto M, Kato H, Haniu H, Ogiwara N, Nakayama N, Taruta S, Saito N. Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes. Nanomedicine-UK. 2012; 7: 981-93.

10. Uehara M, Takahashi J, Hirabayashi H, Hashidate H, Ogihara N, Mukaiyama K, Kato H. Computer-assisted C1-C2 Transarticular Screw Fixation "Magerl Technique" for Atlantoaxial Instability. Asian Spine J. 2012; 6: 168-77.

GRADUATE
  • Master's Program
  • Human Sciences
  • Health Sciences (Master's Program)
  • Master's Curriculum Outline
  • Doctor's Program
  • Medical Sciences
  • Bio-regulation
  • Oncology
  • Regeneration and Reconstruction
  • Brain and Sensory Functions
  • Health and Social Medicine
  • Institute of Pathogenesis and Disease Prevention
  • Health Sciences (Doctor's Program)
  • Doctoral Curriculum Outline
  • Join us in Shinshu Med. School, NAGANO
  • Short-term Elective Training for Foreign Medical Students
  • Shinshu University
  • GET Global Education Center
  • List of Universities with Partnership Agreements