●Chen, C.H., Sawamura, T., Akhmedov, A., Tsai, M.H., Akyol, O., Kakino, A., Chiang, H.H., Kraler, S., Luscher, T.F.: Evolving concepts of low-density lipoprotein: From structure to function. Eur
J Clin Invest, 55:e70019, 2025
●Sasaoka, M., Kakino, A.,Villalobos-Labra, R., Yamashita, Y., Spaans, F., Joshita, S., Hosoda,
H., Uehara, T., Chen, C. H., Davidge, S. T., Sawamura, T.: A novel ELISA system for measuring modified
LDL-adiponectin complex. J
Atheroscler Thromb, 2025.
●Ihara, J., Huang, Y., Takami, Y., Nozato, Y., Takahashi, T., Kakino, A., Wang, C., Wang, Z., Guo, Y., Liu, W., Yin, N., Ohara, R., Fujimoto, T.,
Yoshida, S., Hongyo, K., Koriyama, H., Akasaka, H., Takeshita, H., Sakai,
S., Inoue, K., Isaka, Y., Rakugi, H., Sawamura, T., Yamamoto, K.: Oxidized
low-density lipoprotein potentiates angiotensin II-induced Gq activation
through the AT1-LOX1 receptor complex: Implications for renal dysfunction.
eLife, 13:RP98766, 2024.
●Nguyen, C. T., Nakayama, M., Ishigaki, H., Kitagawa, Y., Kakino, A., Ohno, M., Shingai, M., Suzuki, Y., Sawamura, T., Kida, H., Ito, Y.: Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection in cynomolgus macaque. Virology, 594:110052, 2024.
●Takahashi, K., Aono, J., Nakao, Y., Hamaguchi, M., Suehiro, C., Kurata,
M., Sakaue, T., Kakino, A., Sawamura, T., Inoue, K., Ikeda, S., Suzuki, J. and Yamaguchi, O.: LOX-1
deficiency increases ruptured abdominal aortic aneurysm via thinning of
adventitial collagen. Hypertens Res, 46:63-74, 2023.
● Hosomi, K., Kawashima, H., Nakano, A., Kakino, A., Okamatsu-Ogura, Y., Yamashita, Y., Sasaoka, M., Masuda, D., Yamashita,
S., Chen, C.H., Yuzuriha, S., Hosoda, H., Iida, H. and Sawamura, T.: NanoSPECT
imaging reveals the uptake of 123I-labeled oxidized low-density lipoprotein
in the brown adipose tissue of mice via CD36. Cardiovasc Res, , 119:1008-1020,
2023.
●Sata, M., Kakino, A.(co-first author), Hirata, A., Iida, M., Usami, Y., Harada, S., Fujita,
Y., Kohsaka, S., Izawa, Y., Sawano, M., Oki, K., Sugiyama, D., Takahashi,
S., Takebayashi, T., Sawamura, T. and Okamura, T.: Serum modified high-density
lipoprotein and risk of atherosclerotic cardiovascular disease in a Japanese
community-based nested case-control study. Eur J Prev Cardiol, 29:e193-e195,
2022.
●Ohno, M., Sasaki, M., Orba, Y., Sekiya, T., Masum, M.A., Ichii, O., Sawamura,
T., Kakino, A., Suzuki, Y., Kida, H., Sawa, H. and Shingai, M.: Abnormal blood coagulation
and kidney damage in aged hamsters infected with severe acute respiratory
syndrome coronavirus 2. Viruses, 13:2137, 2021.
●Ohno, M., Kakino, A., Sekiya, T., Nomura, N., Shingai, M., Sawamura, T. and Kida, H.: Critical
role of oxidized LDL receptor-1 in intravascular thrombosis in a severe
influenza mouse model. Sci Rep, 11:15675, 2021.
●Joshita, S., Yamashita, Y., Okamoto, T., Usami, Y., Sugiura, A., Yamazaki,
T., Kakino, A., Ota, M., Sawamura, T. and Umemura, T.: Quantitative and qualitative lipid
improvement with chronic hepatitis C virus eradication using direct-acting
antivirals. Hepatol Res, 51:758-766, 2021.
●Yokoyama, S., Kawai, T., Yamamoto, K., Yibin, H., Yamamoto, H., Kakino, A., Takeshita, H., Nozato, Y., Fujimoto, T., Hongyo, K., Takahashi, T., Nakagami,
F., Akasaka, H., Takami, Y., Takeya, Y., Sugimoto, K., Sawamura, T. and
Rakugi, H.: RAGE ligands stimulate angiotensin II type I receptor (AT1)
via RAGE/AT1 complex on the cell membrane. Sci Rep, 11:5759, 2021.
●Takahashi, T., Huang, Y., Yamamoto, K., Hamano, G., Kakino, A., Kang, F., Imaizumi, Y., Takeshita, H., Nozato, Y., Nozato, S., Yokoyama, S., Nagasawa, M., Kawai, T., Takeda,
T., Fujimoto, T., Hongyo, K., Nakagami, F., Akasaka, H., Takami, Y., Takeya,
Y., Sugimoto, K., Gaisano, H.Y., Sawamura, T. and Rakugi, H.: The endocytosis
of oxidized LDL via the activation of the angiotensin II type 1 receptor.
iScience, 24:102076, 2021.
●Kakino, A., Fujita, Y., Ke, L.Y., Chan, H.C., Tsai, M.H., Dai, C.Y., Chen, C.H. and
Sawamura, T.: Adiponectin forms a complex with atherogenic LDL and inhibits
its downstream effects. J Lipid Res, 62:100001, 2021.
●Hirata, A., Kakino, A.(co-first author), Okamura, T., Usami, Y., Fujita, Y., Kadota, A., Fujiyoshi,
A., Hisamatsu, T., Kondo, K., Segawa, H., Sawamura, T., Miura, K., Ueshima,
H. and Group, S.R.: The relationship between serum levels of LOX-1 ligand
containing ApoAI as a novel marker of dysfunctional HDL and coronary artery
calcification in middle-aged Japanese men. Atherosclerosis, 313:20-25,
2020.
●Kitano, V.J.F., Ohyama, Y., Hayashida, C., Ito, J., Okayasu, M., Sato, T., Ogasawara, T., Tsujita, M., Kakino, A., Shimada, J., Sawamura, T. and Hakeda, Y.: LDL uptake-dependent phosphatidylethanolamine translocation to the cell surface promotes fusion of osteoclast-like cells. J Cell Sci, 133:jcs243840, 2020.
●Lee, A.S., Wang, Y.C., Chang, S.S., Lo, P.H., Chang, C.M., Lu, J., Burns,
A.R., Chen, C.H., Kakino, A., Sawamura, T. and Chang, K.C.: Detection of a high ratio of soluble to
membrane-bound LOX-1 in aspirated coronary thrombi from patients with ST-segment-elevation
myocardial infarction. J Am Heart Assoc, 9:e014008, 2020.
●Kakino, A., Usami, Y., Horiuchi, S., Fujita, Y., Kotani, K., Chen, C.H., Okamura,
T. and Sawamura, T.: A novel cell-free, non-fluorescent method to measure
LOX-1-binding activity corresponding to the functional activity of HDL.
J Atheroscler Thromb, 26:947-958, 2019.
●Nakano, A., Kawashima, H., Miyake, Y., Zeniya, T., Yamamoto, A., Koshino,
K., Temma, T., Fukuda,T., Fujita, Y., Kakino, A., Kanaya, S., Sawamura, T. and Iida, H.: 123I-labeled oxLDL is widely distributed throughout the whole body in mice. Nucl Med Mol Imaging, 52:144-153, 2018.
● Kakino, A., Fujita, Y., Nakano, A., Horiuchi, S. and Sawamura, T.: Developmental
endothelial locus-1 (Del-1) inhibits oxidized low-density lipoprotein activity
by direct binding, and its overexpression attenuates atherogenesis in mice.
Circ J, 80:2541-2549, 2016
● Yokoyama, C., Aoyama, T., Ido, T., Kakino, A., Shiraki, T., Tanaka, T., Nishigaki, K., Hasegawa, A., Fujita, Y., Sawamura,
T. and Minatoguchi, S.: Deletion of LOX-1 Protects against Heart Failure
Induced by Doxorubicin. PLoS One, 11:e0154994, 2016.
● Yokota, C., Sawamura, T., Watanabe, M., Kokubo, Y., Fujita, Y., Kakino, A., Nakai, M., Toyoda, K., Miyamoto, Y. and Minematsu, K.: High Levels of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Stroke: An Age- and Sex-Matched Cross-Sectional Study. J Atheroscler Thromb, 2016
● Yamamoto, K., Kakino, A.(co-first author), Takeshita, H., Hayashi, N., Li, L., Nakano, A., Hanasaki-Yamamoto, H., Fujita, Y., Imaizumi, Y., Toyama-Yokoyama, S., Nakama,
C., Kawai, T., Takeda, M., Hongyo, K., Oguro, R., Maekawa, Y., Itoh, N.,
Takami, Y., Onishi, M., Takeya, Y., Sugimoto, K., Kamide, K., Nakagami,
H., Ohishi, M., Kurtz, T.W., Sawamura, T. and Rakugi, H.: Oxidized LDL
(oxLDL) activates the angiotensin II type 1 receptor by binding to the
lectin-like oxLDL receptor. FASEB J, 29:3342-3356, 2015
● Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura,
T. and Hakeda, Y.: Lectin-like oxidized low-density lipoprotein receptor-1
abrogation causes resistance to inflammatory bone destruction in mice,
despite promoting osteoclastogenesis in the steady state. Bone, 75:170-182,
2015.
● Okamura, T., Sekikawa, A., Sawamura, T., Kadowaki, T., Barinas-Mitchell,
E., Mackey, R.H., Kadota, A., Evans, R.W., Edmundowicz, D., Higashiyama,
A., Nakamura, Y., Abbott, R.D., Miura, K., Fujiyoshi, A., Fujita, Y., Murakami,
Y., Miyamatsu, N., Kakino, A., Maegawa, H., Murata, K., Horie, M., Mitsunami, K., Kashiwagi, A., Kuller,
L.H., Ueshima, H. and Group, E.J.S.: LOX-1 ligands containing apolipoprotein
B and carotid intima-media thickness in middle-aged community-dwelling
US Caucasian and Japanese men. Atherosclerosis, 229:240-245, 2013
● Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka,
H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.: Lectin-like oxidized
low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic
target for human rheumatoid arthritis. Arthritis Rheum, 64:1024-1034, 2012.
● Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R. and Sawamura, T.: Procyanidins
are potent inhibitors of LOX-1: a new player in the French Paradox. Proc
Jpn Acad Ser B Phys Biol Sci, 87:104-113, 2011.
● Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R. and Sawamura, T.: An alternative
protein standard to measure activity of LOX-1 ligand containing apoB (LAB)
- utilization of anti-LOX-1 single- chain antibody fused to apoB fragment.
J Atheroscler Thromb, 18:818-828, 2011.
● Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R. and Sawamura, T.: Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation. Clin Chem, 57:1398-1405, 2011.
● Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita.,
Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H. and Sawamura, T.: LOX-1 mediates vascular lipid retention under hypertensive state. J Hypertens, 28:1273-1280, 2010.
● Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R. and Sawamura, T.: LOX index, a novel predictive biochemical marker for coronary heart disease and stroke. Clin Chem, 56:550-558, 2010.
● Fujita, Y., Kakino, A., Harada-Shiba, M., Sato, Y., Otsui, K., Yoshimoto, R. and Sawamura, T.:
C-reactive protein uptake by macrophage cell line via class-A scavenger
receptor. Clin Chem, 56:478-481, 2010.
● Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita,
H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., Takuwa, Y.,
Kakino, A., Fujita, Y., Tanaka, T., Teramoto, T., Maruyama, Y. and Takeishi, Y.: LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells. Cardiovasc Res, 84:127-136, 2009.
● Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini, L.,
Delneste, Y., Matsuda, H. and Sawamura, T.: Oxidized LDL receptor LOX-1
binds to C-reactive protein and mediates its vascular effects. Clin Chem,
55:285-294, 2009.
● Ikura, T., Tashiro, S., Kakino, A., Shima, H., Jacob, N., Amunugama, R., Yoder, K., Izumi, S., Kuraoka, I.,
Tanaka, K., Kimura, H., Ikura, M., Nishikubo, S., Ito, T., Muto, A., Miyagawa,
K., Takeda, S., Fishel, R., Igarashi, K. and Kamiya, K.: DNA damage-dependent
acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol
Cell Biol, 27:7028-7040, 2007.
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