主要論文

● Okamoto C, Hayakawa Y, Aoyama T, Komaki H, Minatoguchi S, Iwasa M, Yamada Y, Kanamori H, Kawasaki M, Nishigaki K, Mikami A, Minatoguchi S. Excessively low salt diet damages the heart through activation of cardiac (pro) renin receptor, renin-angiotensin-aldosterone, and sympatho-adrenal systems in spontaneously hypertensive rats. PLoS One. 12(12):e0189099. 2017.
●Yokoyama C, Aoyama T, Ido T, Kakino A, Shiraki T, Tanaka T, Nishigaki K, Hasegawa A, Fujita Y, Sawamura T, Minatoguchi S. Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin. PLoS One. 11(5):e0154994. 2016 (責任著者)
●Hayakawa Y, Aoyama T, Yokoyama C, Okamoto C, Komaki H, Minatoguchi S, Iwasa M, Yamada Y, Kawamura I, Kawasaki M, Nishigaki K, Mikami A, Suzuki F, Minatoguchi S. High salt intake damages the heart through activation of cardiac (pro) renin receptors even at an early stage of hypertension. PLoS One. 10(3):e0120453. 2015.
●Shiraki T, Aoyama T, Yokoyama C, Hayakawa Y, Tanaka T, Nishigaki K, Sawamura T, Minatoguchi S. LOX-1 plays an important role in ischemia-induced angiogenesis of limbs. PLoS One. 9(12):e114542. 2014. (責任著者)
●Takahashi S, Kawasaki M, Miyata S, Suzuki K, Yamaura M, Ido T, Aoyama T, Fujiwara H, Minatoguchi S. Feasibility of tissue characterization of coronary plaques using 320-detector row computed tomography: comparison with integrated backscatter intravascular ultrasound. Heart Vessels. 31(1):29-37. 2014
●Hattori A, Kawamura I, Yamada Y, Kanamori H, Aoyama T, Ushikoshi H, Kawasaki M, Nishigaki K, Tamemura G, Minatoguchi S. Elevated plasma GLP-1 levels and enhanced expression of cardiac GLP-1 receptors as markers of left ventricular systolic dysfunction: a cross-sectional study. BMJ Open. 3(9):e003201. 2013
●Minatoguchi S, Aoyama T, Kawai N, Iwasa M, Oda M, Kida K, Kojima S, Goto N, Goto M, Sugishita F, Takai K, Tanaka R, Hiei K, Minagawa T, Yamamoto N, Watanabe I, Yasue T, Kobayashi H. Comparative effect of candesartan and amlodipine, and effect of switching from valsartan, losartan, telmisartan and olmesartan to candesartan, on early morning hypertension and heart rate. Blood Press.:29-37. 2013
●Yamada Y, Kobayashi H, Iwasa M, Sumi S, Ushikoshi H, Aoyama T, Nishigaki K, Takemura G, Fujiwara T, Fujiwara H, Kiso M, Minatoguchi S. Postinfarct active cardiac-targeted delivery of erythropoietin by liposomes with sialyl Lewis X repairs infarcted myocardium in rabbits. Am J Physiol Heart Circ Physiol. 304(8):H1124-33. 2013
●Iwasa M, Yamada Y, Kobayashi H, Yasuda S, Kawamura I, Sumi S, Shiraki T, Yamaki T, Ushikoshi H, Hattori A, Aoyama T, Nishigaki K, Takemura G, Fujiwara H, Minatoguchi S. Both stimulation of GLP-1 receptors and inhibition of glycogenolysis additively contribute to a protective effect of oral miglitol against ischaemia-reperfusion injury in rabbits. Br J Pharmacol. 164(1):119-31. 201
●Kawamura I, Takemura G, Kanamori H, Takeyama T, Kawaguchi T, Tsujimoto A, Goto K, Maruyama R, Watanabe T, Shiraki T, Aoyama T, Fujiwara T, Fujiwara H, Minatoguchi S. Repeated phlebotomy augments angiogenesis to improve blood flow in murine ischemic legs. Am J Physiol Heart Circ Physiol. H372-8. 2010
●Aoyama T, Matsui T, Novikov M, Park J, Hemmings B, Rosenzweig A. Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophic response. Circulation. 111(13):1652-9. 2005 （筆頭著者）
●Nagoshi T, Matsui T, Aoyama T, Leri A, Anversa P, Li L, Ogawa W, del Monte F, Gwathmey JK, Grazette L, Hemmings B, Kass DA, Champion HC, Rosenzweig A. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest. 115(8):2128-38. 2005
●Aoyama T, Takemura G, Maruyama R, Kosai K, Takahashi T, Koda M, Hayakawa K, Kawase Y, Minatoguchi S, Fujiwara H. Molecular mechanisms of non-apoptosis by Fas stimulation alone versus apoptosis with an additional actinomycin D in cultured cardiomyocytes. Cardiovasc Res. 55(4):787-98. 2002 （筆頭著者）
●Aoyama T. Chen, M. Fujiwara, H Masaki, T. Sawamura, T. LOX-1 mediates lysophosphatidylcholine-induced oxidized LDL uptake in smooth muscle cells. FEBS Lett 467: 217-20. 2000 （筆頭著者）
●Aoyama T. Fujiwara, H. Masaki, T. Sawamura, T. Induction of lectin-like oxidized LDL receptor by oxidized LDL and lysophosphatidylcholine in cultured endothelial cells. J Mol Cell Cardiol 31: 2101-14. 1999 （筆頭著者）
●Aoyama T. Sawamura, T. Furutani, Y. Matsuoka, R. Yoshida, M. C. Fujiwara, H. Masaki, T. Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene. Biochem J 339: 177-84. 1999 （筆頭著者）
●Kanoh, M. Takemura, G. Misao, J. Hayakawa, Y. Aoyama T. Nishigaki, K. Noda, T. Fujiwara, T. Fukuda, K. Minatoguchi, S. Fujiwara, H.  Significance of myocytes with positive DNA in situ nick end-labeling (TUNEL) in hearts with dilated cardiomyopathy: not apoptosis but DNA repair. Circulation. 99: 2757-64. 1999
●Moriwaki, H. Kume, N. Sawamura, T. Aoyama T. Hoshikawa, H. Ochi, H. Nishi, E. Masaki, T. Kita, T. Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein. Arterioscler Thromb Vasc Biol 18: 1541-7. 1998
●Kume, N. Murase, T. Moriwaki, H. Aoyama T. Sawamura, T. Masaki, T. Kita, T. Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ Res 83: 322-7. 1998
●Sawamura, T. Kume, N. Aoyama T. Moriwaki, H. Hoshikawa, H. Aiba, Y. Tanaka, T. Miwa, S. Katsura, Y. Kita, T. Masaki, T. An endothelial receptor for oxidized low-density lipoprotein. Nature 386: 73-7. 199