SHISHU UNIVERSITY

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  • Department of Interdisciplinary Genome Sciences and Cell Metabolism

Profile of Departments

Department of Interdisciplinary Genome Sciences and Cell Metabolism

The Department of Interdisciplinary Genome Sciences and Cell Metabolism aims to realize prevention of diseases of the aged and healthy longevity by comprehensively analyzing health from the viewpoints of diet, environment, and genome, through a fusion of vital function science to explain vital functions, food function science to create functional foods, and bioresource science that leads to development of bioresources into drugs.

  • 1. Development of novel functional foods and therapeutic reagents.
  • 2. Production of useful bioactive compounds by microorganisms.
  • 3. Drosophila visual system.

Researchers List

Head of the Department of Interdisciplinary Genome Sciences and Cell Metabolism
Academic Assembly Associate Professor (Institute of Agriculture), Ph. D. in Agriculture
Full-time Contributor
Shinichi Yonekura
Career
2002 Ph.D. Graduate School of Agriculture, Tohoku University
2002 Postdoctoral Research Fellow, National Institutes of Health, USA
2006 Senior Scientisit, Tokyo Metropolitan Institute for Neurosceince
2010 Assistant Professor, Faculty of Agriculture, Shinshu Univeristy
2014 Assistant Professor, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University
2016 Associate Professor, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University
Research Field
Animal Physiology
Research Theme
We are exploring the hidden mechanism of stress response at cellular and molecular levels. We are particularly interested in the relationship between the stress response and a functional disorder in neuronal cell or mammary development.
Home Page
http://karamatsu.shinshu-u.ac.jp/lab/roh/top/top.html
Message
The department aims to be a research center that leads in preventative medicine in the 21st century, by elucidating the basic biological questions by new methods that combine genome sequencing and other omics analysis, and applying the results to the creation of functional foods and drug development that will contribute to the prevention and treatment of various intractable diseases (cancer, lifestyle-related diseases, etc.).
Vice-Director of the Institute for Biomedical Sciences
Academic Assembly Professor (Institute of Agriculture)
Ph. D. in Science
Full-time Contributor
Hiroshi Fujii
Research Field
Biochemistry and Molecular Biology
Research Theme
The research objectives are to understand regulatory mechanisms of genome expression and its function in order to elucidate the basic biological questions such as cell growth, differentiation and development and so on. The results obtained ultimately may lead to development of novel drugs for age-related diseases such as life style-related diseases and cancer. Furthermore, they may contribute to development of novel functional foods for prevention of these diseases.
Academic Assembly Associate Professor (Institute of Agriculture)
Ph. D. in Engineering
Full-time Contributor
Takeshi Hosaka
Research Field
Applied Microbiology
Research Theme
Molecular analysis of the activation mechanism for secondary metabolism of microorganisms and its application to the development of new strategies for exploring useful bioactive compounds.
Academic Assembly Assistant Professor (Institute of Agriculture)
Ph. D. in Agriculture
Full-time Contributor
Ikuo Tomioka
Research Field
Reproductive biology, Nuero science
Research Theme
Determining the reprogramming factors and mechamisms existed in oocytes
Detecting the environmental factor effecting on the gene expression of stem cells
Academic Assembly Assistant Professor (Institute of Agriculture)
Ph. D. in Medicine
Full-time Contributor
Tomohide Takaya
Research Field
Stem cell biology, Cardiovascular medicine
Research Theme
Pathophysiological linkage of cardiovascular-motor system
Regulatory factors and regenerative mechanism of skeletal muscle stem cells
Home Page
http://t-takaya.net/
Academic Assembly Assistant Professor (Institute of Agriculture)
Ph. D. in Applied Life Science
Full-time Contributor
Takakazu Mitani
Research Field
Chemical biology, food science
Research Theme
Search of bioactive compound to prevent lifestyle-related diseases, such as obesity, steatosis, and cancer. Identification of molecular target to the bioactive compound.
Academic Assembly Assistant Professor (Institute of Agriculture)
Ph. D. in Science
Full-time Contributor
Koji Umezawa
Research Field
Biophysics and Bioinformatics
Research Theme
Prediction and interpretation for biomolecular interaction and molecular recognition by theoretical approach based on molecular structure and dynamics.
Academic Assembly Assistant Professor (Institute of Agriculture)
Ph. D. in Agriculture
Full-time Contributor
Tasuku Ogita
Research Field
Functional food science
Research Theme
Effect of functional food on intestinal microbiota
Immunomodulatory function of probiotics
Academic Assembly Professor (Institute of Agriculture)
Ph.D. in Agriculture
Part-time contributor
Tamao Ono
Research Field
Animal Developmental Biotechnology
Research Theme
Transfer and expression of germ cells in bird
Development of strains and their utilization in new world quail and old world quail
Home Page
http://karamatsu.shinshu-u.ac.jp/lab/ono_kagami/hasseiken_e.htm
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Part-time Contributor
Jun Nakayama
Research Field
Pathology, Glycobiology, Histochemistry & Cytochemistry
Research Theme
1. Regulatory mechanism of gastric gland mucin-specific sugar chains in gastric cancer development
2.Clinicopathological significance of sugar chains and glycogenes expressed in tumor
Home Page
http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-2byori/index.html
http://www.shinshu-u.ac.jp/faculty/medicine/eng/graduate/course/36504.html
Academic Assembly Associate Professor (Institute of Agriculture)
Ph. D. in Agriculture
Part-time Contributor
Takeshi Shimosato
Research Field
Animal Science, Molecular Biotechnology, Food Immunology
Research Theme
Our research on the bioregulatory function of food products, particularly in maintaining biological homeostasis via intestinal immunity, has investigated the immunoregulatory effects of probiotic lactic acid bacteria and led to the identification of activation sequences including specific DNA motifs in the genomic DNA. Exploiting this property may also prove useful in the design and production of new physiologically functional foods/feeds.
Home Page
http://karamatsu.shinshu-u.ac.jp/lab/shimolab/index.html
Academic Assembly Associate Professor (Institute of Agriculture)
Ph. D. in Fisheries Sciences
Part-time Contributor
Shigeru Katayama
Research Field
Improvement of bioactive compounds by chemical, enzymatic and genetic modifications
Research Theme
We investigate the health functionality of food-derived bioactive compounds and their improvement by different kinds of modification techniques
Home Page
http://karamatsu.shinshu-u.ac.jp/lab/fs/english.html
Academic Assembly Assistant Professor (Institute of Agriculture)
Ph. D. in Science
Part-time Contributor
Shunsuke Suzuki
Research Field
Molecular Biology, Genome Biology
Research Theme
Clarify the relevance of transposable elements to the evolution of mammalian genomic imprinting and of human gene regulatory mechanisms and diseases.
Academic Assembly Assistant Professor (Institute of Agriculture)
Ph. D. in Engineering
Part-time Contributor
Masaki Ihara
Research Field
Protein Engineering, Metabolic Engineering
Research Theme
We are trying to establish the green bio-refinery industry using microalgae re-enegineered by protein engineering and metabolic engineering techniques.
National Institutes of Health, USA
Chi-Hon Lee
Research Field
Neuroscience
Research Theme
Using the Drosophila visual system as a model, we study how neurons form complex yet stereotyped synaptic connections during development and how the assembled neural circuits extract visual attributes, such as color and motion, to guide animal behaviors.
Home Page
https://science.nichd.nih.gov/confluence/display/snc/Home
National Institutes of Health, USA
Chun-Yuan Ting
Research Field
Neuroscience
Research Theme
Most regions of vertebrate and invertebrate brains are organized in columns and layers, which facilitate information processing and propagating. Our long-term goal is to determine how visual circuits are assembled during development.
Seoul National University, Korea
Jae Yong Han
Research Field
Animal molecular genetics, Biomodulation and agriculural biotechnology
Research Theme
Production of genetically modified animals (poultry etc.) using agricultural biotechnolgy and its agriculturally practical and scientific applications (model animals etc.).
Home Page
http://age.snu.ac.kr
http://biomodulation.snu.ac.kr
Seoul National University, Korea
Jeong-Yong Suh
Research Field
Structural biology, Molecular biophysics
Research Theme
Structural mechanism of transcriptional regulation, Protein folding and interaction probed by NMR spectroscopy
Home Page
http://bionmr.snu.ac.kr
University of Guelph, Canada
Yoshinori Mine
Research Field
Food derived anti-inflammatory peptides and their molecular targets, mucosal immunology and molecular allergology of food allergens, moleclular mechanisms of food allergy tolerance induction.
Research Theme
One of the main research topics is gut health and immunity, and identifying bioactive food factors that promote gut health. It is known that gut inflammatory damage and oxidative stress are large contributing factors in the pathogenesis of various human disorders including cancer, cardiovascular disease, diabetes, inflammatory conditions, and neurological processes. Thus, identifying bioactive dietary peptides with anti-oxidative or anti-inflammatory properties provides promising applications in the reduction of local inflammation in the gut, as well as reducing the incidence of disorders such as cancer and diabetes. Our work also focuses on the allosteric activation of the calcium-sensing receptor (CaSR), which is involved in the anti-inflammatory effects of dietary dipeptides.
Another main research focus is the allergology of egg allergens (e.g. Glycation) such as ovomucoid and ovalalbumin. We examine the modulation of Th1/Th2-associated cytokines and T-regulatory cells, the mechanism of antigen transportation across the human intestinal epithelium.
Home Page
http://www.uoguelph.ca/foodscience/
http://www.yminelab.com/ymine.html
Seoul National University, Korea
Heebal Kim
Research Field
Computational Evolution, Bioinformatics
Research Theme
Computational molecular evolution, genome-wide association study in complex trait and genome-wide expression profiling
Home Page
http://biopop.snu.ac.kr