SHISHU UNIVERSITY

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  • Department of Biological Sciences for Intractable Neurological Diseases

Profile of Departments

Department of Biological Sciences for Intractable Neurological Diseases

We aim to develop new methods of treatment from basic research, understanding the clinical pathological conditions and development of novel therapeutic approaches, based on 2 main areas of research: deposition of misfolded proteins including amyloid proteins, which is the cause of intractable neurological diseases, and faults in the nerve synapse function, in collaboration with medical, agricultural, and engineering researchers.

  • 1. Electron microscopic view on post synoptic density (PSD).
  • 2. Distribution of Neuroligins (NLs) on the surface of the dendritic spine.
  • 3. Amyloid deposits in the tongue of mouse by Congo red staining under polarized light.

Researchers List

Head of the Department of Biological Sciences for Intractable Neurological Diseases
Academic Assembly Professor (Institute of Health Sciences), Ph. D. in medicine
Full-time Contributor
Masahide Yazaki
Career
1998 Graduated from Shinshu University Graduate School of Medicine
2004 Assistant Professor, School of Medicine, Shinshu University
2011 Associate Professor in Shinshu University School of Medicine
2017 Professor in Shinshu University School of Medicine
Research Field
Neurology, Protein metabolism
Research Theme
Elucidation of pathophysiology on amyloidoses and establishment of novel therapeutic approaches
Message
The Department of Biological Sciences for Intractable Neurological Diseases aims to explain the pathological conditions of amyloidoses, which is a representative intractable condition, and nerve synapse dysfunction which is a cause of neurodegenerative disease and psychiatric disease, and thereby lead to the establishment of novel therapeutic approaches. As a research institute located in Nagano Prefecture, one of the few areas of longevity in the world, we wish to contribute to further extending the average life expectancy in Japan by explaining intractable diseases and developing therapeutic approaches.
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Full-time Contributor
Katsuhiko Tabuchi
Research Field
Neurophysiology
Research Theme
To investigate the mechanisms of synapse formation and functions focusing on synaptic cell adhesion molecules that are also related to neuropsychiatric disorders, such as autism and schizophrenia.
Home Page
http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-2seiri/index.html
Academic Assembly Senior Assistant Professor (Institute of Medicine)
Ph. D. in Pharmacy
Full-time Contributor
Jinko Sawashita
Research Field
Medical chemistry, Molecular biology, Pharmacology
Research Theme
Mechanisms of amyloid fibril formation and transmission, and approaches to new preventive and/or suppressive treatments on amyloidosis, Effects of functional foods and exercise on health promotion
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Part-time Contributor
Keiichi Higuchi
Research Field
Aging Biology (Aging and Anti-aging Research)
Research Theme
Biomedical Research on Aging and Age-related Diseases
1. Amyloidosis
2. Anti-aging treatment
3. Senescence Accelerated Mouse (SAM)
Home Page
http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/grdkarei/i-byotai/
http://www.samrc.jp/firste.html
Shinshu University Specially Appointed Professor
Ph. D. in Medicine
Part-time Contributor
Kunihiro Yoshida
Research Field
clinical and molecular bases of hereditary neurological diseases
Research Theme
clinical assessment, neuropathology and analysis of gene mutation and molecular pathogenesis of hereditary neurological diseases (spinocerebellar ataxia, disorders of brain iron metabolism, leukoencephalopathy, etc)
Academic Assembly Associate Professor (Institute of Medicine)
Ph. D. in Medicine
Part-time Contributor
Yoshiki Sekijima
Research Field
Neurology, Clinical genetics, Amyloidosis
Research Theme
Pathogenesis of and novel therapeutic strategies to ameliorate the transthyretin amyloidoses.
Early Diagnosis of transthyretin-type cerebral amyloid angiopathy
Academic Assembly Associate Professor (Institute of Medicine)
Ph. D. in Medicine
Part-time Contributor
Takeshi Uemura
Research Field
Molecular neuroscience
Research Theme
Study on molecular mechanisms of synapse formation underlying neuronal network formation and synaptic dysfunction in neurodevelopmental disorders
Home Page
http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-2seiri/uemura.html
Shanghai Jiao Tong University, China
Weidong Li
Research Field
Pathogenesis and therapeutics of neuropsychiatric disorders such as Schizophrenia, Depression, ADHD and NF1; Adult neurogenesis; Molecular cognition; iPS and brain tumor.
Research Theme
Prof. Weidong Li, Deputy Dean, Research Management Division, Shanghai Jiao Tong University, Vice Dean of Bio-X Institutes / Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Assistant Director of Brian Science and Technology Research Center of Shanghai Jiao Tong University. Dr. Li was graduated from China Medical University in 1996 and got his PhD from Shinshu University Schools of Medicine (Japan) in 2001. He did his post-doc researches at UCLA since 2002 and was promoted to the assistant researcher (research assistant professor) in the Department of Neurobiology in 2007. He was a Project Leader of the National Basic Research Program of China (973 Program) after he set up his lab in China since 2009. His lab focus on the mechanism and therapeutic of neuropsychiatric disorders by using animal modeling approaches. Recently, he also initiated a “China Super Brain Research Center” to investigate the brain function of the people with extraordinary abilities. Dr. Li won several prestigious awards, including Young Investigator Awards of National Alliance for Research on Schizophrenia and Depression (NARSAD) and the Children’s Tumor Foundation in US, Shanghai “Shu Guang” Scholar, Shanghai “Pujiang Talent” and Shanghai “Eastern Scholar”. Editor of Molecular Brain.