工学部 研究紹介_2018_英語版

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Creation of Heterocyclic Compounds by Organic Cynthesis: Development of novel catalysts and highly selective reactionsSugaLabThereisasubtledeferenceamongchemicalstructuresthathastodowiththethree-dimensionalarrangementsofatomsinspace.Thesearrangementdifferinthewaythatarighthandandalefthanddiffer-thatistheyaremirrorimagesofeachother.Manymedicinalchemicalscanexistintwomirrorimageforms,anditisoftentruethatoneofthemisabettermedicineandtheothermayevenbeharmful.Inourlaboratory,wehavebeeninvestigatinganewmethodologyforthesynthesisofmedicinallyimportantopticallyactiveheterocycliccompoundswiththedesiredhandedness.Organicsynthesiscontributesnotonlyforthecreationofmedicinesandagrochemicalsbutalsoforthesynthesisoforganicmaterialssuchasorganicsemiconductors.Fortheorganicsynthesis,itisimportanttodevelopanefficientandselectivereactiontoaffordonlyadesiredproduct.Ourgoalistodevelopsuchnovelcatalystsforthereaction,whichwillcontributetoawiderangeofchemicalindustries.HiroyukiSugaProfessorofChemistryHe joined Shinshu University in 1998. His research interest is the synthesis of optically active heterocyclic compounds with biological activity. Organic compounds are synthesized by using several reagents, solvents, and glassware in a hood. Graduatesfrommylaboratorynowworkinpharmaceutical,agrochemical,andchemicalcompanies.Ourstudentscanapplytheirknowledgeoforganicchemistrytothefieldsofpolymersandevenotherchemicalmaterialsaswellasrelativelysmallorganicmolecules.Anorganicmoleculecoordinatestoacatalystanditisactivated.写真サイズ高さ4.35cm×幅3.6cm配置位置横15.3cm、縦2.85cm3DstructureofaproductisdeterminedbyNMR.In the FutureAfter GraduationArtificial Membrane for Cell-Like MicrochemicalSystemsOkumuraLabAbiologicalcellisanextremelysophisticatedmicrochemicalsystem.Thisfacthasledscientiststoconstructacell-likemicrochemicalsystembyhumanhands.Forthesystem,artificialplasmamembranesareessentialastheyseparatetheinnerworldfromtheoutsideandbecometheinterfacebetweenthetwoworlds.Ourresearchgroupstudieslipidmembranevesiclesthathavethesizecomparabletobiologicalcells(giantliposomes)assuchartificialcellmembranes.Theconstructionofasophisticatedartificialcellwillbeoneofthemajorscientificandtechnologicalachievements.Althoughthereclearlyisalongwayahead,manyresearchgroupsaroundtheworldhavebeenworkingontheproblem.Thetechnology,ifestablished,willbeusedinmanybio-relatedfields,suchasmedicineandagriculture.Anexampleofpossibleapplicationsisadrugdeliverysystemmoreefficientandcompatibletohumanbodies.YukihisaOkumura,ProfessorChemistry of artificial lipid membrane vesicles (liposomes)Bio-mimetic microchemicalsystems.Working with giant vesicles. Giant vesicles are as large as biological cells and can be directly observed on an optical microscope.Micromanipulation of a giant vesicle. Various substances may be introduced into the vesicle by microinjection through a hollow needle.Manygraduatesfoundtheircareersinvariouschemistry-relatedfieldsincompanies.Throughthesisworks,studentsinourgroupareexpectedtoimprovetheskillsnecessaryasanengineer;carefulobservation,logicalthinkingandgoodresearchplanning.In the FutureAfter GraduationMaterialsChemistryMaterialsChemistry9