Faculty of Textile Science and Technology Research Activity2016|Shinshu Univ

58Department of Applied BiologyUnderstanding the nature of stem cells and controlling their fateThe spermatogenic potential of GS cells is expected to nd application not only in treating male infertility, but also in producing superior livestock. In addition, mGS cells are expected to serve as another source of pluripotent stem cells such as iPS cells. In this context, GS cells might be called multipotent stem cells with the potential to contribute to a wide range of elds.Outlook for researchThe value of the market associated with regenerative medicine is expected to grow to 1 trillion yen in 2020 (according to statistics from the Ministry of Economy, Trade and Industry). It is my hope that our future colleagues will be able to play a remarkable role in growth industries, including in regenerative medicine.Outlook for students after graduationThe pluripotency potential of GS cells. Left: mGS cells de-dierentiated (rejuvenated) from GS cells. mGS cells possess pluripotency like iPS cells. Right: mGS can contribute to the formation of “chimera mice.” mGS-derived tissue in the chimaera mice exhibited GFP expression.GS cells. Left: Mouse GS cells growing in vitro. Center: Spermatogenesis in the testis transplanted with GS cells expressing green uorescent protein (GFP). Right: Mouse ospring produced from sperm derived from GS cells expressing GFP. The ospring also exhibited green uorescence under UV light (highlighted with).Seiji TakashimaTenure-track Assistant ProfessorAfter receiving a doctorate (in engineering) from the Tokyo Institute of Technology, Assistant Professor Takashima worked as a research fellow at the University of Tokyo before coming Kyoto University as an assistant professor. His areas of research are regenerative medicine and stem cell biology.Regenerative medicine using iPS cells is expected to serve as a novel approach for curing disease. My lab is focusing on germline stem (GS) cells, tissue-specific stem cells in testis. Although GS cells have already committed to germ cell lineage, they also have pluripotency potential and often de-differentiate into multipotent GS (mGS) cells that possess pluripotency like iPS cells. The goal of our research is to understand the unique nature of GS/mGS cells and control their fate.Department of Applied BiologyTo investigate the characteristics of the biological material, to develop a new medical deviceDecellularized tissues are prepared from biological tissues, and are clinically used in Europe and U.S. The decellularized materials show biocompatibilities at implanted sites. It is possible to transplant animal tissues to humans by decellularization treatments. The object of our research is an application and an investigation of these decellularized tissue properties for use in medical devices. The vacuum pressure impregnation technique is able to easily rehydrate materials. Our research aims to fabricate a new medical material using this technique.After receiving a doctorate in Tokyo Medical and Dental University, Assistant Professor Negisih worked as a JSPS post doctor at Sapporo Medical University before coming ADEKA as a research worker. His areas of research are biological materials.Biological materials such as a decellularized material are able to mimic complex structures of animal tissues and can be used as a remodeling material by patients’ own cells. It would be possible to fabricate tissues and organ in vitro by combining these materials and stem cells. Using other led techniques may lead a novel medical device fabrication. Outlook for researchStudents learn to think by themselves and take initiative in this research lab, and this prepares them to work by well in groups or by themselves. They are equipped to pursue careers across a variety of scientic elds.Outlook for students after graduation(Left) A native porcine artery after 3 days in rat carotid transplantation. (Right) A decellularizzed porcine artery after 2 weeks in rat carotid transplantation. (A) A freeze-dried aorta after 10 min immersion into PEG. (B) A freeze-dried aorta after PEG hydration by vacuum pressure impregnation (VPI). The VPI treated aorta showed homogeneous rehydration.Jun NegishiAssistant ProfessorNative porcine artery: occlusionDecellularized porcine artery: patent


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