■工学部_研究紹介_2017_英語版ファイル161220

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1.0 μmBacterial Cellulose Nanofiber-Amazing World of Fiber Spinning by Bacteria -MizunoLabCelluloseisproducedbysomekindsofbacteriaaswellasplants.Itiscalledasbacterialcelluloseormicrobialcellulose,andisusedforvariousindustrialpurposes.Inourlaboratory,wefocusonthefunctionoftheproteincomplexparticipatingincellulosebiosynthesis,whichbehaveslikeafiberspinningmachine.Itistoosmalltoobservethestructureofthisproteincomplexbymicroscope.ThuswearetryingtostudyitsstructurebyX-raycrystallographicanalysisattheatomiclevel.Thewidthofcellulosefibrilextrudedfromasingleproteincomplexisabout1.5nm.Innature,thesecellulosefibersarebundledtoformcellulosefibers(10-100nm)basedon?thearrayofproteincomplexonthecellsurfaceandthemovementofbacterium.Ifthearrayofproteincomplexcanbecontrolled,itmightbepossibletomakeacellulosenanofiberwithavarietyofthicknessandlength.MasahiroMizuno2005: Ph.Dfrom Tokyo University of Agriculture and Technology2006-: Assistant Professor of Faculty of Engineering, Shinshu UniversityX-ray crystallography of carbohydrate related enzymes.TEM image of cellulose producing bacterium (left), and SEM image of bacteria cellulose (right).Crystals(0.2mm)(left)andthree-dimensionalstructure(right)oftheproteincomposingthecellulosespinningmachine.MoststudentsstayatShinshuUniversityfortheirgraduatestudies.Othersfindjobsinmanufacturingcompaniesinvariousfieldssuchaschemistry,electronics,andfood.Chemistry& MaterialsEngineeringIn the FutureAfter GraduationCreation and understanding of new molecules and their reactivity though catalysis developmentTodaLabOurgroup’sinterestisthedesignanddevelopmentofneworganicmolecules.Thereareanumberoforganiccompoundsinyourlife-smallmoleculesinmedicinalandagriculturalchemistrytolargemoleculesinmaterialscience.Organicsynthesisisanessentialtoolforbothacademiaandindustry,andinordertofacilitatefurtherdevelopmentoforganicchemistryweshouldcontinuetryingtocreateandunderstandnewmoleculesandtheirreactivity.Ourgroupfocusesoncatalysisdevelopmentbecausethebehaviorofnewmoleculescanbeevaluatedbytheresultsofcatalyticreactions.Duetotheexpansionofscienceandtechnology,furtherprogressinorganicsynthesishasbeenrequired.Ingeneral,achemicalreactionprovidesnotonlyadesiredproductbutalsoundesiredproducts.Webelievethatcatalysisgovernsorganicreactions,leadingtoselectiveproductformation.Ourcontinuouseffortsonthedevelopmentofefficienttransformationswouldcontributetoindustryaswellasacademicresearchinthenearfuture.Yasunori TodaAssistant ProfessorPh.D.: Tohoku UniversityPostdoctoral Fellow:Vanderbilt UniversityHe began his career at ShinshuUniversity in 2015. His research focuses on catalysis development. Organicchemistscanworkinseveralfields,thusmanyformergroupmembersarenowinpharmaceutical,agrochemical,andchemicalcompanies.Ourstudentscanlearntosolveproblemsthroughexperienceinthelabwhichshouldbevaluabletonumerousjobseventhoughtheyarenotrelatedtochemistry.Chemistry& MaterialsEngineeringIn the FutureAfter GraduationTrial and error leads to optimized reaction conditions. These reactions are run in an oil bath to maintain the temperature. Selectivity of catalytic reactions is measured by the use of High Performance Liquid Chromatography (HPLC). 13

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