血液内科学

概要

血液内科の診療は、白血病・悪性リンパ腫など造血器腫瘍に対する造血幹細胞移植を中心に行っています。年間50例前後の造血幹細胞移植を施行しており、2013年までに約400例の移植症例の蓄積があります。また難治性貧血や出血性疾患などの診療にも従事しています。研究面では多施設共同研究に積極的に参加し、また移植のデータベースを元に臨床研究を行っています。リンパ腫などの病態解析では基礎研究も可能です。

研究テーマ

造血器悪性腫瘍に対する各種移植治療成績の検討
T細胞大顆粒リンパ球白血病の病態解析
成熟NK細胞性腫瘍の病態解析
造血不全症候群の病態の解析
慢性リンパ性白血病の病態解析

スタッフ

教授

田中榮司

講師

中澤英之、関口 和(兼務)

その他

12名

学生数

博士課程学生数

2名

研究室の所在及び連絡先

長野県松本市旭3丁目1番1号
信州大学医学部内科学第二教室
TEL:0263-37-2634, FAX:0263-32-9412

主要な成果/Major Publications

  1. Sakai H, Hosono N, Nakazawa H, Przychodzen B, Polprasert C, Carraway HE, Sekeres MA, Radivoyevitch T, Yoshida K, Sanada M, Yoshizato T, Kataoka K, Nakagawa MM, Ueno H, Nannya Y, Kon A, Shiozawa Y, Takeda J, Shiraishi Y, Chiba K, Miyano S, Singh J, Padgett RA, Ogawa S, Maciejewski JP, Makishima H. A novel genetic and morphologic phenotype of ARID2-mediated myelodysplasia.Leukemia. 2017 Nov 3. doi: 10.1038/leu.2017.319. [Epub ahead of print] No abstract
  2. Kawakami T, Nakazawa H, Kurasawa Y, Sakai H, Nishina S, Senoo N, Senoo Y, Ishida F. Intern Med. Severe Infection of Pseudomonas aeruginosa during Eculizumab Therapy for Paroxysmal Nocturnal Hemoglobinuria. 2018 Jan 1;57(1):127-130. doi: 10.2169/internalmedicine.9151-17. Epub 2017 Oct 11.
  3. Sekiguchi N, Nishina S, Kawakami T, Sakai H, Senoo N, Senoo Y, Ito T, Saito H, Nakazawa H, Koizumi T, Ishida F. Oral cyclophosphamide was effective for Coombs-negative autoimmune hemolytic anemia in CD16+CD56- chronic lymphoproliferative disorder of NK-cells. Int J Hematol. 2017 Jun;105(6):854-858. doi: 10.1007/s12185-016-2170-4. Epub 2016 Dec 27.
  4. Andersson EI, Tanahashi T, Sekiguchi N, Gasparini VR, Bortoluzzi S, Kawakami T, Matsuda K, Mitsui T, Eldfors S, Bortoluzzi S, Coppe A, Binatti A, Lagstrom S, Ellonen P, Fukushima N, Nishina S, Senoo N, Sakai H, Nakazawa H, Kwong YL, Loughran TP, Maciejewski JP, Mustjoki S, Ishida F. High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. Blood. 2016 Nov 17;128(20):2465-2468. Epub 2016 Oct 3. No abstract available.
  5. Nakazawa H, Sakai H, Kawakami T, Hirabayashi Y, Nakazawa K, et al. An Aggressive Transformation to EBV-Positive Hodgkin Lymphoma after Bendamustine-Containing Chemotherapy for Marginal Zone Lymphoma. J Hematol Thrombo Dis 2016 4:246. doi:10.4172/2329-8790.1000246
  6. Tanahashi T, Sekiguchi N, Matsuda K, Matsumoto A, Ito T, Nakazawa H, Ishida F. A screening method with lymphocyte percentage and proportion of granular lymphocytes in the peripheral blood for large granular lymphocyte (LGL) leukemia. Int J Hematol. 2017 Jan;105(1):87-91. doi: 10.1007/s12185-016-2092-1. Epub 2016 Sep 29.
  7. Tokutake T, Baba H, Shimada Y, Takeda W, Sato K, Hiroshima Y, Kirihara T, Shimizu I, Nakazawa H, Kobayashi H, Ishida F. Exogenous Magnesium Chloride Reduces the Activated Partial Thromboplastin Times of Lupus Anticoagulant-Positive Patients. PLoS One. 2016 Jun 29;11(6):e0157835. doi: 10.1371/journal.pone.0157835. eCollection 2016.
  8. Tanahashi T, Sekiguchi N, Matsuda K, Takezawa Y, Ito T, Kobayashi H, Ichikawa N, Nishina S, Senoo N, Sakai H, Nakazawa H, Ishida F. Cell size variations of large granular lymphocyte leukemia: Implication of a small cell subtype of granular lymphocyte leukemia with STAT3 mutations. Leuk Res. 2016 Jun;45:8-13. doi: 10.1016/j.leukres.2016.04.001. Epub 2016 Apr 4.
  9. Nakazawa H, Makishima H, Ito T, Ota H, Momose K, Sekiguchi N, Yoshizawa K, Akamatsu T, Ishida F. Screening tests using serum tissue transglutaminase IgA may facilitate the identification of undiagnosed celiac disease among Japanese population. Int J Med Sci. 2014 Jun 3;11(8):819-23. doi: 10.7150/ijms.8854. eCollection 2014.
  10. Nakazawa H, Nishina S, Mimura Y, Kawakami T, Senoo Y, Sakai K, NakazawaK, Kitano K. Tumor lysis syndrome in a chronic lymphocytic leukemia patient with pleural effusion after oral fludarabine and cyclophosphamide therapy. Int J Hematol. 2014 Jun;99(6):782-5. doi: 10.1007/s12185-014-1560-8. Epub 2014 Mar 2.
  11. Ishida F, Nakazawa H, Takezawa Y, Matsuda K, Asano N, Sano K, Sakai H, Ito T. Richter transformation in the brain from chronic lymphocytic leukemia. J Clin Exp Hematop. 2013;53(2):157-60.
  12. Matsuda K, Ishida F, Ito T, Nakazawa H, Miura S, Taira C, Sueki A, Kobayashi Y, Honda T. Spliceosome-related gene mutations in myelodysplastic syndrome can be used as stable markers for monitoring minimal residual disease during follow-up. Leuk Res. 2012 Nov;36(11):1393-7. doi: 10.1016/j.leukres.2012.07.019. Epub 2012 Aug 14.
  13. Sekiguchi N, Asano N, Ito T, Momose K, Momose M, Ishida F: Elevated serum granulysin and its clinical relevance in mature NK-cell neoplasms. Int J Hematol 96: 461-468, 2012
  14. Ito T, Makishima H, Nakazawa H, Senoo Y, Senoo N, Ishida F: Donor lymphocyte infusion for extranodal NK/T cell lymphoma, nasal type, relapsed after allogeneic hematopoietic SCT. Bone Marrow Transplant 46: 1270-1271, 2011
  15. Asano N, Suzuki R, Ohshima K, Kagami Y, Ishida F, Yoshino T, Ogawa H, Morishima Y, Nakamura S: Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma. Int J Hematol. 91: 426-435; 2010
  16. Ishida F, Kwong YL: Diagnosis and management of natural killer-cell malignancies. Expert Rev Hematol. 3: 593-602; 2010
  17. Ishida F, Nishina S, Asano N, Sasaki S, Sekiguchi N, Nakazawa H, Ito T, Shikama N: Late relapse of extranodal natural killer/T cell lymphoma, nasal type, after more than ten years. Leuk Lymphoma. 51: 171-173; 2010
  18. Ishida F, Okubo K, Ito T, Okumura N, Souri M, Ichinose A: Spontaneous regression of the inhibitor against the coagulation factor XIII A subunit in acquired factor XIII deficiency. Thromb Haemost. 104: 1284-1285; 2010
  19. Asano N, Yamamoto K, Tamaru J, Oyama T, Ishida F, Ohshima K, Yoshino T, Nakamura N, Mori S, Yoshie O, Shimoyama Y, Morishima Y, Kinoshita T, Nakamura S: Age-related Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin lymphoma in elderly patients. Blood. 113: 2629-2636, 2009
  20. Ito T., Makishima H., Nakazawa H., Kobayashi H., Shimodaira S., Nakazawa Y., Kitano K., Matsuda K., Hidaka E.,Ishida F. Promising approach for aggressive NK cell leukaemia with allogeneic haematopoietic cell transplantation. Eur J Haematol 2008; 81(2): 107-111.
  21. Makishima H., Komiyama Y., Asano N., Momose K., Nakamura S.,Ishida F. Peripheral T-cell lymphoma following diffuse large B-cell lymphoma associated with celiac disease. Intern Med 2008; 47(4): 295-298.

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