Graduate School of Medicine Human Sciences
Surgery(Thoracic,Cardiovascular,Breast & Endocrine)

 http://www.shinshu-surgery2.jp/

Professor: Jun AMANO
Associate Professor: Ken-ichi ITO, Kazuo YOSHIDA
Senior Assistant Professor: Tamaki TAKANO, Daisuke FUKUI

Assistant Professor: Takayuki SHIINA, Makoto KURAI, Yasuhiro MOCHIZUKI, Yuko WADA FABISCH, Kazuma MAENO, Kazutoshi HAMANAKA


CLINICAL MAIN PROJECTS

The Division of Cardiovascular Surgery(Director: Jun AMANO, Professor, : junamano@shinshu-u.ac.jp

  1. Complete coronary revascularization (CABG) for patients with ischemic heart disease, and improvement of cardiac function by bone marrow implantation.
  2. Improvement of QOL with preservation of patient’s own valve by repair and Maze procedure in valvular heart disease.
  3. Development of surgical and regenerative therapeutic modality for improvement of QOL in patients with congestive heart disease.
  4. Improvement of operative results in thoracic aortic surgery especially for the elderly and aortic rupture.
  5. Establishment of less invasive surgical treatment for abdominal aortic aneurysm with minimally invasive surgery and endovascular treatment.
  6. Promotion of less invasive hybrid therapy combination with intravascular therapy and surgical revascularization for peripheral arterial disease.

The Division Thoracic Surgery (Director: Kazuo YOSHIDA, Clinical Professor, : kxy13 @shinshu-u.ac.jp)

  1. Limited surgery for early lung cancer (ex. radical segmentectomy or partial resection)
  2. Minimal invasive surgery, including VATS, for lung cancer
  3. Extended radical surgery for advanced lung cancer
  4. Neo-adjuvant therapy for advanced lung cancer
  5. Adjuvant therapy for lung cancer
  6. Integrated therapy for epithelial thymic tumor
  7. Videoscopic total thymectomy
  8. Integrated therapy for malignant mesothelioma
  9. Lung volume reduction surgery for advanced emphysema
  10. Establishment of educational program in VATS for residents

The Division of Breast and Endocrine Surgery (Director: Ken-ichi ITO, Clinical Professor, : kenito@shinshu-u.ac.jp)

  1. Comprehensive treatment for all forms and stages of breast cancer
  2. Comprehensive treatment for all forms and stages of thyroid cancer
  3. Comprehensive treatment for all forms parathyroid diease
  4. Stereotactic vacuum-assisted core needle biopsy (Mammotome)
 

CURRENT RESEARCH TOPICS
(see also http://www.shinshu-u.ac.jp/graduate/medicine/master/m-science/geka.html)

Our major topics of research are surgical oncology, gene therapy, regeneration therapy, organ transplantation, artificial organ, and response to surgical intervention. Our goal is to perform translational research from bench to bed side in the broad spectrum of interdisciplinary approach.

Surgical Oncology Group

  1. Mechanism of tumorigenesis
  2. The relation of gene expression and the clinical results in cancer
  3. Mechanism of tolerance of cancer to anti-cancer drugs
  4. Anaerobic bacteria for cancer gene therapy (see also http://www.anaeropharma.co.jp/index_e.html)
  5. Cardiac tumor

Transplantation-Regeneration Therapy Group

  1. Development of regeneration therapy for ischemic legs and myocardium using bone marrow transplantation and anaerobic bacteria
  2. Mechanism and prevention of chronic cardiac rejection
  3. Development of less invasive cardiopulmonary bypass system

Response to Surgical Intervention Group

  1. Mechanism of lung injury and development of method to prevent it
  2. Developement of new devise and material for VATS.
References(2005-2009)

Takano T, Goto H, Ichinose H, Kono T, Tanaka J, Kuroiwa S, Nishimura K. A case of iliac arteriovenous fistula presenting with iliac artery aneurysm preoperatively diagnosed by ultrasonography. Ann Thorac Cardiovasc Surg, 15(2):133-136, 2009

Ito K, Ito T, Okada T, Watanabe T, Gomi K, Kanai T, Mochizuki Y, Amano J. A Case of Brain Metastases from Breast Cancer that Responded to Anastrozole Monotherapy. The Breast Journal. 15(4):435-437, 2009

Maeno K, Nakajima A, Conseil G, Rothnie A, Deeley RG, Cole SP. Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1). Drug Metab Dispos. 37(7):1411-1420, 2009

Koyama H, Kobayashi N, Harada M, Takeoka M, Kawai Y, Sano K, Fujimori M, Amano J, Ohhashi T, Kannagi R, Kimata K, Taniguchi S, Itano N. Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis: pivotal role of a hyaluronan-rich tumor microenvironment. Am J Pathol. 172(1):179-193, 2008

Tachi Y, Fukui D, Wada Y, Koshikawa M, Shimodaira S, Ikeda U, Amano J. Changes in angiogenesis-related factors in serum following autologous bone marrow cell implantation for severe limb ischemia. Expert Opin Biol Ther. 8(6):705-712, 2008

Fujita T, Igarashi J, Okawa ER, Gotoh T, Manne J, Kolla V, Kim J, Zhao H, Pawel BR, London WB, Maris JM, White PS, Brodeur GM. CHD5, a Tumor Suppressor Gene Deleted From 1p36.31 in Neuroblastomas. J Natl Cancer Inst. 100(13):940-949, 2008

Eguchi T, Kato K, Shiina T, Kondo R, Yoshida K, Amano J. Pulmonary torsion of the lingula following a segmentectomy of the left upper division. Gen Thorac Cardiovasc Surg. 56(10):505-508, 2008

Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH. Identification of cells initiating human melanomas. Nature. 451:345-349, 2008

Ueno T, Habicht A, Clarkson MR, Albin MJ, Yamaura K, Boenisch O, Popoola J, Wang Y, Yagita H, Akiba H, Ansari MJ, Yang J, Turka LA, Rothstein DM, Padera RF, Najafian N, Sayegh MH. . The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest. 118(2):742-751, 2008

Komatsu A, Nagasaki K, Fujimori M, Amano J, Miki Y. Identification of novel deletion polymorphisms in breast cancer. Int J Oncol. 33(2):261-270, 2008

Ito K, Kanai T, Gomi K, Watanabe T, Ito T, Komatsu A, Fujita T, Amano J. Endoscopic-assisted skin-sparing mastectomy combined with sentinel node biopsy. NZ J Surg. 78(10):894-898, 2008

Sone S, Nakayama T, Honda T, Tsushima K, Li F, Haniuda M, Takahashi Y, Hanaoka T, Takayama F, Koizumi T, Kubo K, Yamanda T, Kondo R, Fushimi H, Suzuki T. CT findings of early-stage small cell lung cancer in a low-dose CT screening programme. Lung Cancer. 56(2):207-215, 2007

Sone S, Nakayama T, Honda T, Tsushima K, Li F, Haniuda M, Takahashi Y, Suzuki T, Yamanda T, Kondo R, Hanaoka T, Takayama F, Kubo K, Fushimi H. Long-term follow-up study of a population-based 1996-1998 mass screening programme for lung cancer using mobile low-dose spiral computed tomography. Lung Cancer. 58:329-341, 2007

Hidaka A, Hamaji Y, Sasaki T, Taniguchi S, Fujimori M. Exogeneous Cytosine Deaminase Gene Expression in Bifidobacterium breve I-53-8w for Tumor-Targeting Enzyme/Prodrug Therapy. Biosci. Biotechnol. Biochem. 71(12):2921-2926, 2007

Koyama H, Hibi T, Isogai Z, Yoneda M, Fujimori M, Amano J, Kawakubo M, Kannagi R, Kimata K, Taniguchi S, Itano N. Hyperproduction of Hyaluronan in Neu-induced Mammary Tumor Accelerates Angiogenesis through Stromal Cell Reaction. Possible Involvement of Versican / PG-M. Am J Pathol. 170(3):1086-1099, 2007

Hamanaka K, Jian MY, Weber DS, Alvarez DF, Townsley MI, Al-Mehdi AB, King JA, Liedtke W, Parker JC. TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs. Am J Physiol Lung Cell Mol Physiol. 293(4):923-932, 2007

Miyahara T, Hamanaka K, Weber DS, Drake DA, Anghelescu M, Parker JC. Phosphoinositide 3-kinase, Src, and Akt modulate acute ventilation-induced vascular permeability increases in mouse lungs. Am J Physiol Lung Cell Mol Physiol. 293(1):11-21, 2007

Tissier R, Hamanaka K, Kuno A, Parker JC, Cohen MV, Downey JM. Total liquid ventilation provides ultra-fast cardioprotective cooling. J Am Coll Cardiol. 49(5):601-605, 2007

Makiuchi A, Yamaura K, Mizuno S, Matsumoto K, Nakamura T, Amano J, Ito K. Hepatocyte growth factor prevents pulmonary ischemia-reperfusion injury in mice. J Heart Lung Transplant. 26(9):935-943, 2007

Okawa ER, Gotoh T, Manne J, Igarashi J, Fujita T, Silverman KA, Xhao H, Mosse YP, White PS, Brodeur GM. Expression and sequence analysis of candidates for the 1p36.31 tumor suppressor gene deleted in neuroblastomas. Oncogene. 27(6):803-810, 2007

Sakai T, Makita M, Akiyama F, Uehara K, Kasumi F, Horii R, Sakamoto G. Intraductal papilloma with bloody discharge from montgomery's areolar tubercle examined by ductoscopy from the areola. Breast Cancer. 13(1):104-106, 2006

Machida T, Fujita T, Ooo ML, Ohira M, Isogai E, Mihara M, Hirato J, Tomotsune D, Hirata T, Fujimori M, Adachi W, Nakagawara A. Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas. Oncogene. 25(13):1931-1942, 2006

Yoshida K, Takasuna K, Hamanaka K, Saito G, Haniuda M, Amano J. Rupture of a large cell neuroendocrine carcinoma, causing early local recurrence. Ann Thorac Cardiovasc Surg. 12(1):56-59, 2006

Sakaguchi M. Reply to jahangiri and clark. Eur J Cardiothorac Surg. 29(2):264-265, 2006

Shiraishi Y, Katsuragi N, Nakajima Y, Hashizume M, Takahashi N, Miyasaka Y. Pneumonectomy for complex aspergilloma: is it still dangerous? Eur J Cardiothorac Surg. 29(1):9-13, 2006

Sasaki T, Fujimori M, Hamaji Y, Hama Y, Ito K, Amano J, Taniguchi S. Genetically engineered Bifidobacterium longum for tumor-targeting enzyme-prodrug therapy of autochthonous mammary tumors in rats. Cancer Sci. 97(7):649-657, 2006

Fujimori M. Novel strategy for Breast Cancer therapy. Breast Cancer. 13(1):1- 1, 2006

Fujimori M. Genetically engineered bifidobacterium as a drug delivery system for systemic therapy of metastatic Breast Cancer patients. Breast Cancer. 13(1):27-31, 2006

Furusawa T, Tsukioka K, Fukui D, Sakaguchi M, Seto T, Terasaki T, Wada Y, Amano J. The effects of a neutrophil elastase inhibitor on the postoperative respiratory failure of acute aortic dissection. Thorac Cardiovasc Surg. 54(6):404-407, 2006

Yoshida K, Kitahara H, Kondo R, Kurai M, Hyougotani A, Amano J. Giant intraatrial septal aneurysm originating from a branch of the left coronary artery. Jpn J Thorac Cardiovasc Surg. 54(10):432-436, 2006

Koshikawa M, Shimodaira S, Yoshioka T, Kasai H, Watanabe N, Wada Y, Seto T, Fukui D, Amano J, Ikeda U. Therapeutic angiogenesis by bone marrow implantation for critical hand ischemia in patients with peripheral arterial disease: a pilot study. Curr Med Res Opin. 22(4):793-798, 2006

Kurai M, Kondo R, Kobayashi N, Hyogotani A, Yoshida K, Amano J. Castleman's disease arising from the chest wall. Jpn J Thorac Cardiovasc Surg. 54(12):555-557, 2006

Yoshida K, Kobayashi N, Kurai M, Hyogotani A, Kondo R, Amano J. A subtotalsternectomy successfully reconstructed with composix mesh. Ann Thorac Cardiovasc Surgc. 12(6):420-424, 2006

Yoshida K, Kondo R, Wang Q, Doerschuk CM. Neutrophil cytoskeletal rearrangements during capillary sequestration in bacterial pneumonia in rats. Am J Respir Crit Care Med. 174(6):689-698, 2006

Sakaguchi M, Kitahara H, Watanabe T, Kono T, Fukui D, Amano J. Successful surgical treatment for acute aortic dissection in pregnancy with Marfan's syndrome. Jpn J Thorac Cardiovasc Surg. 53(4):220-222, 2005

Hanazaki K, Kajikawa S, Shimozawa N, Matsushita A, Machida T, Shimada K, Yazawa K, Koide N, Adachi W, Amano J. Perioperative blood transfusion and survival following curative hepatic resection for hepatocellular carcinoma. Hepatogastroenterology. 52(62):524-529, 2005

Hanazaki K, Matsushita A, Nakagawa K, Misawa R, Amano J. Risk factors of long-term survival and recurrence after curative resection of hepatocellular carcinoma. Hepatogastroenterology. 52(62):552-557, 2005

Hanazaki K, Matsushita A, Nakagawa K, Misawa R, Amano J. Risk factors of intrahepatic recurrence after curative resection of hepatocellular carcinoma. Hepatogastroenterology. 52(62):580-586, 2005

Yoshida K, Saito G. Two Successful Cases in the Treatment of Post-operative ronchial stump fistulae. Ann Thorac Cardiovasc Surg. 11(3):194-197, 2005

Sakai T, Fujimori M, Tominaga Y, Kanai T, Ito K, Shingu K, Amano J, Kushima H, Tsutiya S. A case of unilateral gravid macromastia in 23-year-old Japanese woman associated with elevated serum CA19-9. Breast Cancer. 12(3):238-242, 2005

Sakaguchi M, Kitahara H, Seto T, Furusawa T, Fukui D, Yanagiya N, Nishimura K, Amano J. Surgery for acute type A aortic dissection in pregnant patients with Marfan syndrome. Eur J Cardiothorac Surg. 28(2):280-285, 2005

Kono T, Amano J, Sakaguchi M, Kitahara H. Successful resection of cardiac metastatic liposarcoma extending into the SVC, right atrium, and right ventricle. J Card Surg. 20(4):364-365, 2005

Kono T, Kitahara H, Sakaguchi M, Amano J. Cardiac rupture after catheter ablation procedure. Ann Thorac Surg. 80(1):326-327, 2005

Sakai T, Tsuchiya S, Hama Y, Matsuyama I, Fujimori M. Can cytological findings predict intraductal spread of breast cancer? Histopathological case-control study. Pathol Int. 55(12):775-780, 2005

Yoshida K. Aneurysmal bone cyst of the rib: report of a case. Surg Today. 35(12):1073-1075, 2005

Ohtsu Y, Johkura K, Ito K, Akashima T, Asanuma K, Ogiwara N, Oka T, Komuro I, Sasaki K, Amano J. Stimulation of P19CL6 with multiple reagents induces pulsating particles in vivo. Curr Med Res Opin. 21(5):795-803, 2005

Fukui D, Yang XP, Chiba S. Neurogenic double-peaked vasoconstriction of human gastroepiploic artery is mediated by both alpha1- and alpha2-adrenoceptors. Br J Pharmacol. 144(6):737-742, 2005

Fujita T, Ito K, Izumi H, Kimura M, Sano M, Nakagomi H, Maeno K, Hama Y, Shingu K, Tsuchiya S, Kohno K, Fujimori M. Increased nuclear localization of transcription factor Y-box binding protein 1 accompanied by up-regulation of P-glycoprotein in breast cancer pretreated with paclitaxel. Clin Cancer Res. 11(24):8837-8844, 2005

Izawa A, Sekimura N, Uchikawa S, Yazaki Y, Kinoshita O, Owa M, Kubo K, Ikeda U, Sekiguchi M, Kitahara H, Amano J, Imamura H. A critical increase in right-to-left shunt after acute myocardial infarction in a 68-year-old male with tetralogy of Fallot. Int Heart J. 46(1):167-174, 2005

Ito K, Fujimori M, Shingu K, Hama Y, Kanai T, Koyama H, Amano J. Pulmonary tuberculosis in a patient receiving intensive chemotherapy for metastatic breast cancer. Breast J. 11(1):87-88, 2005

Ito K, Komatsu A, Kanai T, Koyama H, Hama Y, Shingu K, Fujimori M, Amano J. A case of premenopausal breast cancer showing remarkable elevation of serum alkaline phosphatase level during treatment with LH-RH analog. Breast J. 11(6):523-524, 2005

White PS, Thompson PM, Gotoh T, Okawa ER, Igarashi J, Kok M, Winter C, Gregory SG, Hogarty MD, Maris JM, Brodeur GM. Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma. Oncogene. 24(16):2684-2694, 2005