Graduate School of Medicine ＞ Human Science
＞ Sports Medical Sciences

　 : isports@shinshu-u.ac.jp

Professor: Hiroshi NOSE
Assistant Professors: Yoshi-ichiro KAMIJO, Shizue MASUKI

Summary of Activity

The goal of our research is to provide countermeasures against global warming and aging society. Human beings have distributed widely over the earth since they were born 5 million years ago by their high abilities to move great distances in an upright position and to adapt to various severe environments. However, the recently developed amenity for air condition and motorization has deteriorated these abilities and accelerated the global warming by consuming huge amounts of natural energy resources to attain the amenity. Our challenge is to cut off this vicious cycle by re-activating the inborn abilities in human beings.

In our laboratory, we have applied our laboratory achievements to the field and, inversely, picked up some novel ideas for the laboratory studies from the field. For the field, we have managed a health-promotion program for middle-aged and older people, called “Jukunen Taiiku Daigaku”, for these 11 years, in which 3,000 people participated. To reply to requests raised by the field, we have made a education program in a master course of Shinshu University Graduate School of Medicine since 2004 to produce talents who are able to contribute to health promotion in the aging society.


Research Projects

1) Blood pressure and thermal regulations during exercise in humans: We have studied the effects of acute dehydration on blood pressure and thermal regulations during exercise in humans. Also, we have developed regimens to increase exercise performance in a hot environment by maintaining blood volume by drinking sports drinks and by expanding blood volume by heat acclimatization and/or aerobic training.

2) Exercise training program for individuals to prevent lifestyle and age associated diseases: We have successfully accumulated a database of the effects of “high-intensity interval walking training” on physical fitness, blood pressure, and lifestyle-associated disease indexes in over 3,000 middle-aged and older people, which is used for make a training program fitted for individuals.

3) Search for genes activated by exercise in humans and animal models: We have studied blood pressure and metabolic regulations during exercise in mice deficient of some related genes. Based on these findings, we have compared the regulations among human subjects who have different single nucleotide polymorphisms of the genes and participate in the “Jukunen Taiiku Daigaku” program.　　

References
  1. Goto M, Okazaki K, Kmaijo Y, Ikegawa S, Masuki S, Miyagawa K, and Nose H: Protein and carbohydrate supplementation during 5-day aerobic training enhanced plasma volume expansion and thermoregulatory adaptation in young men. J. Appl. Physiol. in press.

  2. Morikawa M, Okazaki K, Masuki S, Kamijo Y, Yamazaki T, Gen-no H, and Nose H: Physical fitness and indices of lifestyle-related diseases before and after interval walking training in middle-aged and older males and females. Br J Sports Med, in press.

  3. Masuki S, Mori M, Tabara Y, Miki T, Sakurai A, Morikawa M, Miyagawa K, Higuchi K, Nose H; Shinshu University Genetic Research Consortium: Vasopressin V1a receptor polymorphism and interval walking training effects in middle-aged and older people. Hypertension, 55:747-54, 2010.

  4. Masuki S and Nose H: Increased cerebral activity suppresses baroreflex control of heart rate in freely moving mice. J Physiol(Lond),587: 5783-94, 2009.

  5. Nose H, Morikawa M, Yamazaki T, Nemoto K, Okazaki K, Masuki S, Kamijo Y, and Gen-no H: Beyond epidemiology: field studies and the physiology laboratory as the whole world. J Physiol (Lond), 587: 5569-75, 2009.

  6. Okazaki K, Goto M, and Nose H: Protein and carbohydrate supplementation increases aerobic and thermo-regulatory capacities. J Physiol (Lond), 587: 5585-90, 2009a.

  7. Okazaki K, Hayase H, Ichinose T, Mitono H, Doi T, and Nose H: Protein and carbohydrate supplementation after exercise increases plasma volume and albumin content in older and young men. J Appl Physiol 107: 770-9, 2009b.

  8. Okazaki K, Ichinose T, Mitono H, Chen M, Masuki S, Endoh H, Hayase H, Tatsuya Doi T, and Nose H: Impact of protein and carbohydrate supplementation on plasma volume expansion and thermoregulatory adaptation by aerobic training in older men. J Appl Physiol 107: 725-33, 2009c.

  9. Yamazaki T, Gen-no H, Kamijo Y, Okazaki K, Masuki S, and Nose H: A new device to estimate VO2 during incline walking by accelerometry and barometry. Med Sci Sports Exerc 41: 2213-9, 2009.

  10. Okada Y, Kamijo Y, Okazaki K, Masuki S, Goto M, and Nose H: Pressor responses to isometric biting are evoked by somatosensory receptors in periodontal tissue in humans. J Appl Physiol 107: 531-9, 2009.

  11. Nemoto K, Genno H, Masuki S, Okazaki K, Nose H: Effects of high-intensity interval walking training on physical fitness and blood pressure in middle-aged and older people. Mayo Clinic Proceedings 82: 803-811, 2007.

  12. Masuki S, Eisenach JH, Schrage WG, Johnson CP, Dietz NM, Wilkins BW, Sandroni P, Low PA and Joyner MJ: Reduced stroke volume during exercise in postural tachycardia syndrome. J Appl Physiol 103: 1128-1135, 2007.

  13. Ichinose T, Okazaki K, Masuki S, Mitono H, Chen M, Endoh H, Nose H: Ten-day endurance training attenuates the hyperosmotic suppression of cutaneous vasodilation during exercise but not sweating. J Appl Physiol 99: 237-243, 2005.

  14. Mitono H, Endoh H, Okazaki K, Ichinose T, Masuki S, Takamata A, and Nose H: Acute hypoosmolality attenuates the suppression of cutaneous vasodilation with increased exercise intensity. J Appl Physiol 99: 902-908, 2005.

  15. Kamijo Y, Okumoto T, Takeno Y, Okazaki K, Inaki M, Masuki S, Nose H: Transient cutaneous vasodilatation and hypotension after drinking in dehydrated and exercising men. J Physiol (Lond) 568:689-698, 2005.