: jnaka　shinshu-u.ac.jp 　　Please fill "@ " in the blank.

Professor: Jun NAKAYAMA
Associate Professor: Takashi EHARA
Assistant Professor(Senior): Junya MASUMOTO
Assistant Professor: Hisashi SHIMOJO

Our research goal is to elucidate molecular basis of human diseases such as cancer and inflammation. To this end we are examining human pathological specimens as well as animal models using a variety of analytical techniques including morphology, biochemistry, molecular biology, microbiology, and immunology. We are also involved in diagnostic pathology service including histopathology, cytology, and autopsy.

Ongoing projects in our laboratory are as follows:
* Role of cell adhesion molecules expressed in cancer
* Role of immunity in glomerulonephirits
* Role of NLR in inflammation
* Role of O-glycan in kidney disease

Yamazaki T, Masumoto J, Agematsu K, Sawai N, Kobayashi S, Shigemura T, Yasui K, Koike K. Anakinra improves sensory deafness in a Japanese patient with Muckle-Wells syndrome, possibly by inhibiting the cryopyrin inflammasome. Arthritis Rheum 58:864-868, 2008.

Kamijo Y, Hora K, Kono K, Takahashi K, Higuchi M, Ehara T, Kiyosawa K, Shigematsu H, Gonzalez FJ, Aoyama T. PPARalpha protects proximal tubular cells from acute fatty acid toxicity. J Am Soc Nephrol 18:3089-3100, 2007.

Kobayashi T, Masumoto J, Tada T, Hongo K, Nomiyama T, Nakayama J. Prognositic significance of the immunohistochemical staining of cleaved-caspase-3, an activated-form of caspase-3, in gliomas. Clin Cancer Res 13:3868-3874, 2007.

Kasama S, Kawakubo M, Suzuki T, Nishizawa T, Ishida A, Nakayama J. RNAi-mediated knock-down of TRPV1 prevents forepaw inflammatory hyperalgesia in rat. Eur J Neurosci 25:2956-2963, 2007.

Harada O, Suga T, Suzuki T, Nakamoto K, Kobayashi M, Nomiyama T, Nadano D, Ohyama C, Fukuda MN, Nakayama J. The role of trophinin, an adhesion molecule unique to human trophoblasts, in progression of colorectal cancer. Int J Cancer 121:1072-1078, 2007.

Sugihara K, Sugiyama D, Byrne J, Wolf DP, Lowitz KP, Kobayashi Y, Kabir-Salmani M, Nadano D, Aoki D, Nozawa S, Nakayama J, Mustelin T, Ruoslahti E, Yamaguchi N, Fukuda MN. Trophoblast cell activation by trophinin ligation: Possible role in human embryo implantation. Proc Natl Acad Sci USA 104:3799-3804, 2007.

Harada O, Ota H, Katsuyama T, Hidaka E, Ishizaka K, Nakayama J. Esophageal gland duct adenoma: Immunohistochemical comparison with the normal esophageal gland and ultrastractural analysis. Am J Surg Pathol 31:469-475, 2007.

Omachi T, Kawai Y, Mizuno R, Nomiyama T, Miyagawa S, Ohhashi T, Nakayama J. Immunohistochemical demonstration of proliferating lymphatic vessels in colorectal carcinoma and its clinicopathological significance. Cancer Lett 246:167-172, 2007.

Haugan K, Miyamoto T, Takeishi Y, Kubota I, Nakayama J, Shimojo H, Hirose M. Rotigaptide (ZP123) improves atrial conduction slowing in chronic volume overload-induced dilated atria. Basic Clin Pharmacol Toxicol 99:71-79, 2006.

Masumoto J, Yang K, Varambally S, Hasegawa M, Tomlins SA, Qiu S, Fujimoto Y, Kawasaki A, Foster SJ, Horie Y, Mak TW, Nunez G, Chinnaiyan AM, Fukase K, Inohara N. Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. J Exp Med 203:203-213, 2006.