Assistant Professor: Chifumi Fujii, Tamotsu Tsukahara
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Our major research works are conducted by use of several kinds of animals (mouse, rat, dog etc) as in vivo experiments. Additionally, molecular biological experiments using cultured cell system in vitro for physiological evaluation.
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Integrative analysis of the autonomic nervous system as system control
Electric signals from anesthetized and/or conscious animal are detected in sympathetic nerves for integration.
Biological evaluation of safety for carbon nano-tube
Biocompatibility of carbon nano-tube has been evaluated mainly using mice. |
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- Koyama S, Kim Y-A, Hayashi T, Takeuchi K, Fujii C, Kuroiwa N, Koyama H, Tsukahara, and Endo M. In vivo immunological toxicity in mice of carbon nanotubes with impurities. Carbon 47: 1365-1372, 2009
- Miyazaki T, Bub JD, and Iwamoto Y. c-Jun NH2-terminal kinase mediates leptin-stimulated androgen-independent prostate cancer cell proliferation via signal transducer and activator of transcription 3 and Akt. Biochim Biophys Acta 1782: 593-604, 2008
- Bub JD, Miyazaki T, and Iwamoto Y. Adiponectin as a growth inhibitor in prostate cancer cells. Biochem Biophys Res Commun 340: 1158-1166, 2006
- Tsukahara T, Tsukahara R, Yasuda S, Makarova N, Valentine WJ, Allison P, Yuan H, Baker DL, Li Z, Bittman R, Parrill A, and Tigyi G. Different residues mediate recognition of 1-O-oleyllysophosphatidic acid and rosiglitazone in the ligand binding domain of peroxisome proliferator-activated receptor gamma. J Biol Chem 281: 3398-3407, 2006
- Koyama S, Endo M, Kim Y-A, Hayashi T, Yanagisawa T, Osaka K, Koyama H, Haniu H, and Kuroiwa N. Role of systemic T-cells and histopathological aspects after subcutaneous implantation of various carbon nanotubes in mice. Carbon 44: 1079-1092, 2006
- Fujii C, Nakamoto Y, Lu P, Tsuneyama K, Popivanova BK, Kaneko S, Mukaida N. Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. Int J Cancer 114: 209-218, 2005
- Endo M, Koyama S, Matsuda Y, Hayashi T, Kim Y-A. Thrombogenicity and blood coagulation of a microcatheter prepared from carbon nanotube-nylon-based composite. Nano Lett 2005; 5: 101-105, 2005
- Onuma M, Bub JD, Rummel TL, and Iwamoto Y. Prostate cancer cell-adipocyte interaction: leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH2-terminal kinase. J Biol Chem 278: 42660-42667, 2003
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