Graduate School of Medicine ＞ Human Science
＞ Infection and Host Defense



Associate Professor: Kazunaga AGEMATSU
Senior Assistant Professor: Masaya TAKAMOTO
Assistant Professor: Hisashi NAGASE

Summary of Activity
Research task in our Department is to clarify the mechanism of immune responses to opportunistic infection in patients with AIDS and transplant recipients.


Research Projects

Treatment of streptococcosis with recombinant human IgG against Streptococcus pneumoniae
（Kazunaga AGEMATSU）

Study on molecules regulating Pneunocystis pneumonia
Study on the effects of endocrine disruptors on immune responses and host defense
（Masaya TAKAMOTO）

Study on defensive mechanisms of Leishmania infection
（Hisashi NAGASE）
References
  1. Hu T, Takamoto M, Hida S, Tagawa Y, Sugane K. IFN-gamma deficiency worsen Pneumocystis pneumonia with Th17 development in nude mice.Immunol Lett. 127(1):55-9, 2009.

  2. Minegishi Y, Saito M, Nagasawa M, Takada H, Hara T, Tsuchiya S, Agematsu K, Yamada M, Kawamura N, Ariga T, Tsuge I, Karasuyama H.　Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome.　J Exp Med. 206(6):1291-301, 2009.

  3. Masumoto J, Yamazaki T, Ohta K, Nakayama J, Agematsu K.　Interleukin-1beta suppression in Blau syndrome: comment on the article by Martin et al. Arthritis Rheum. 60(8):2544-5, 2009.

  4. Hida S, Yamasaki S, Sakamoto Y, Takamoto M, Obata K, Takai T, Karasuyama H, Sugane K, Saito T, Taki S Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. Nat Immunol 10(2):214-22, 2009.

  5. Yan H, Takamoto M, Sugane K.　Exposure to Bisphenol A Prenatally or in Adulthood Promotes TH2 Cytokine Production Associated with Reduction of CD4+CD25+ Regulatory T Cells. Environ Health Perspect. 116(4):514-9, 2008.

  6. Nagase H, Jones KM, Anderson CF, Noben-Trauth N.　Despite increased CD4+Foxp3+ cells within the infection site, BALB/c IL-4 receptor-deficient mice reveal CD4+Foxp3-negative T cells as a source of IL-10 in Leishmania major susceptibility. J Immunol. 179(4):2435-44, 2007.