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@  : jnaka@shinshu-u.ac.jp
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Professor: Jun NAKAYAMA
Assistant Professor(Senior): Motohiro KOBAYASHI
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Our research goal is to elucidate the biological
functions of glycan chains expressed on cell surface or secreted from cells under pathological
conditions such as cancer and inflammation. To this end we are examining human pathological
specimens as well as transgenic/knockout mice for glycosyltranserases using a variety of
analytical techniques including pathology, biochemistry, molecular biology, microbiology,
and immunology. |
Ongoing projects in our laboratory are as follows:
* Role of O-glycans expressed in gastric mucosa infected with Helicobacter pylori
* Role of O-glycans expressed in gastric malignant lymphoma of MALT type
* Role of chondroitin sulfate E expressed by glioma cells on tumor progression |
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- Suzawa K, Kobayashi M, Sakai Y, Hoshino H, Watanabe M, Harada O, Ohtani H, Fukuda M, Nakayama J: Preferential induction of peripheral lymph node addressin on high endothelial venule-like vessels in the active phase of ulcerative colitis. Am J Gastroenterol 102, 1499-1509, 2007.
- Kobayashi M, Hoshino H, Masumoto J, Fukushima M, Suzawa K, Kageyama S, Suzuki M, Ohtani H, Fukuda M, Nakayama J: GlcNAc6ST-1-mediated decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates directs disease activity of ulcerative colitis. Inflamm Bowel Dis 15, 697-706, 2009.
- Hatakeyama S, Sugihara K, Nakayama J, Akama TO, Wong SA, Kawashima H, Zhang J, Smith DF, Ohyama C, Fukuda M, Fukuda MN: Identification of mRNA splicing factor as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells. Proc Natl Acad Sci USA 106, 3095-3100, 2009.
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