Professor:Toru Aizawa
Associate Professor: Tsuyoshi Tada

Through research on medical education and outcome analysis, we launch highly motivated tomorrow's doctor. Clinical and basic research on diabetes mellitus, brain tumor and hydrocephalus.

Research Field

Method and outcome analysis of medical education.

Problems in elderly patients with diabetes; Pharmacotherapy of type 2 diabetes; Insulin exocytosis.

Treatment of brain tumor; Establishment of HGF therapy for communicating hydrocephalus.

Publications

＜Medical Education＞
Sakurai A, Kimura T, Fukushima Y, Tada T, Aizawa T. Interdisciplinary freshman seminar for health science students. Medical Education Japan 2007;38:23-28.

＜Diabetology＞
2007
Katakura M, Naka M, Kondo T, Komatsu M, Yamauchi K, Hashizume K, Aizawa T. Development, worsening, and improvement of diabetic microangiopathy in older people: six-year prospective study of patients under intensive diabetes control. J Am Geriatr Soc 2007;55:541-547.

Katakura M, Naka M, Kondo T, Komatsu M, Yamauchi K, Hashizume K, Aizawa T. Nagano Elderly Diabetes Study Group. Normal mortality in the elderly with diabetes under strict glycemic and blood pressure control: Outcome of 6-year prospective study. Diabetes Res Clin Pract 2007;78:108-114.

Komatsu M, Schermerhorn T, Noda M, Straub SG, Aizawa T, Sharp GWG. Glucose and nutrient-induced increase in insulin secretion in the absence of a rise in [Ca2+]i. In: Commentaries on Perspectives in Diabetes, Vol 2 (1993-1997). Edited by Robertson PR. American Diabetes Association, 2007 (in press)”

2005
Yamada T, Komatsu M, Komiya I, Miyahara Y, Shima Y, Matsuzaki M, Ishikawa Y, Mita R, Fujiwara M, Furusato N, Nishi K, Aizawa T. Development, progression, and regression of microalbuminuria in Japanese patients with type 2 diabetes under tight glycemic and blood pressure control: the Kashiwa study. Diabetes Care 2005;28:2733-2738.

Aizawa T, Komatsu M. Rab27a: a new face in β cell metabolism-secretion coupling. J Clin Invest 2005;115:227-230.

2004
Komatsu M, Ohfusa H, Sato Y, Yajima H, Yamauchi K, Aizawa T, Hashizume K. Strong inverse correlation between serum adiponectin level and heart rate-corrected QT interval in an apparently healthy population: a suggestion for a direct antiatherogenic effect of adiponectin. Diabetes Care 2004;27:1237-1238.

Katakura M, Komatsu M, Sato Y, Hashizume K, Aizawa T. Primacy of β-cell dysfunction in the development of hyperglycemia: a study in the Japanese general population. Metabolism 2004;53:949-953.

＜Neurosurgery＞
2007
Kobayashi T, Matsumoto J, Tada T, Nomiyama T, Hongo K, Nakayama J. Prognostic significance of the immunohistochemical staining of cleaved caspase-3, an activated form of caspase-3, in Gliomas: Clin Cancer Res 13,3868-3874, 2007

2006
Tada T, Zhan H, Tanaka Y, Hongo K, Matsumoto K, Nakamura T. Intraventricular administration of hepatocyte growth factor treats mouse communicating hydrocephalus induced by transforming growth factor β1. Neurobiology of Disease 21: 576-586, 2006

Kusano Y, Tanaka Y, Takasuna H, Wada N, Tada T, Kakizawa Y, Hongo K. Transient cerebellar mutism caused by bitemporal damage to the dentate nuclei after the second posterior fossa surgery. Case report. Journal of Neurosurgery 104: 329-331, 2006

Hashimoto T, Tada T, Ikeda S. Presurgical factors affecting patient satisfation with pallidal surgery in Parkinson's disease. Stereotact Funct Neurosurg 84: 24-27, 2006

2005
Shikama N, Ogawa K, Tanaka S, Toita T, Nakamura K, Uno T, Ohnishi H, Itami J, Tada T, Saeki N. Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma. A multiinstitutional, retrospective review of 180 patients. Cancer 104: 126-134, 2005

Zhan H, Tada T, Fujikura E, Matsumoto K, Tanaka Y, Hongo K. A container for transporting small laboratory animals for magnetic resonance imaging. Short communication. Journaj of Neuroscience Methods 144: 143-146, 2005

Tada T, Nguyen JB, Hitoshi Y, Watson NP, Dunn JF, Ohara S, Nagano S, Kosai K, Israel MA. Diffuse encephaloventriculitis and substantial leukoencephalopathy after intraventricular administration of recombinant adenovirus. Neurological Research 27: 378-386, 2005