Medicine (Respirology, Infectious Disease, Allergology)

Staff List

Contact

Summary of Activity

Our department makes efforts to elucidate the basic and clinical problems in the fields of respiratory, infectious and allergy diseases by means of various research modalities of case study, epidemiology, molecular biology, genetic study and animal study. The major diseases studied in our department include asthma/ COPD, lung cancer, respiratory infectious diseases, interstitial lung diseases, pulmonary hypertension, sleep apnea syndrome and high-altitude pulmonary edema that mainly occurs in the highland of Shinshu area in Japan.

Research Subject

• ・The molecular genetics in high-altitude adaptation and acclimatization.
• ・Studying various drugs on prevention of group 3 pulmonary hypertension by using rat model.
• ・The pathophysiology of IgG4-related respiratory disease
• ・Seeking the optimal treatment for non-tuberculous mycobacteria infection.
• ・Development of novel examination techniques in bronchoscope field.
• ・Research on the pathophysiology of COPD

Outlook for Research

Respiratory, infectious and allergy diseases are increasingly important, which is expected to occupy 4 diseases (COPD, pneumonia, lung cancer, and HIV infection) among the world's 10 leading causes of death in 2030. There are a lot of unsolved questions in many refractory diseases. However, accumulation of research results will provide possibilities to overwhelm these diseases and create a bright future.

Major Publications

1. Komatsu M, Yamamoto H, Kitaguchi Y, Kawakami S, Matsushita M, Uehara T, Kinjo T, Wada Y, Ichiyama T, Urushihata K, Ushiki A, Yasuo M, Hanaoka M. Clinical characteristics of non-idiopathic pulmonary fibrosis, progressive fibrosing interstitial lung diseases：A Single-center retrospective study. Medicine.2021；100（issue13）:e25322

2. Nozawa S, Urushihata K, Machida R, Hanaoka M. The risk assessment by clinical background and cephalometry for obstructive sleep apnea with CPAP indication in Japanese. Sleep and Biological Rhythms. 2021；19:145–154

3. Koizumi T, Kanda S, Nihonmatu R, Gomi D, Sekiguchi N, Noguchi T, Fukushima T, Kobayashi T, Yamamoto H, Takeda T. Primary mediastinal germ cell tumors- A retrospective analysis of >30 years of experience in a single institution. Thoracic Cancer. 2021；12（issue6）：807-813

4. Kawabata H, Fujimoto S, Sakai T, Yanagisawa H, Kitawaki T, Nara K, Hagihara M, Yamamoto H. Patient’s age and d-dimer levels predict the prognosis in patients with TAFRO syndrome. International Journal of Hematology.2021；114：179-188

5. Nishie K, Yamamoto S, Yamaga T, Horita N, Mori R, Gouda MA, Hanaoka M. Prophylactic cranial irradiation for extensive-stage small cell lung cancer (Protocol). Cochrane Library.2021

6. Urushihata K, Yunden Droma, Ito M, Hanaoka M. Hypoxic Ventilatory Response to Acute and Prolonged Hypoxic Exposures in Subjects Susceptible to High-altitude Pulmonary Edema. Shinshu Medical journal. 2021；69（4）：179-187

7. Sonehara K, Tateishi K, Araki T, Komatsu M, Yamamoto H, Koizumi T, Hanaoka M. The Role of Immune-Related Adverse Events in Prognosis and Efficacy Prediction for Patients with Non-Small Cell Lung Cancer Treated with Immunotherapy: A Retrospective Clinical Analysis. Oncology. 2021；99：271-279

8. Sonehara K, Tateishi K, Araki T, Komatsu M, Yamamoto H, Hanaoka M. Prognostic value of the geriatric nutritional risk index among patients with previously treated advanced non-small cell lung cancer who subsequently underwent immunotherapy. Thorac Cancer. 2021；1-7

9. Kinugawa Y, Uehara T, Iwaya M, Asaka S, Kobayashi S, Nakajima T, Komatsu M, Yasuo M, Yamamoto H, Ota H. IL-6 expression helps distinguish Castleman's disease from IgG4-related disease in the lung. BMC Pulm Med. 2021 Jul 10；21：219

10. Akahane J, Ushiki A, Kosaka M, Ikuyama Y, Matsuo A, Hachiya T, Yoshiike F, Koyama S, Hanaoka M. Blood urea nitrogen-to-serum albumin ratio and A-DROP are useful in assessing the severity of Pneumocystis pneumonia in patients without human immunodeficiency virus infection. Elsevier. 2021；27：707-714

11. Komatsu M, Yamamoto H, Matsui S, Terasaki Y, Hebisawa A, Iwasawa T, Johkoh T, Baba T, Miyamoto A, Handa T, Tomii K, Waseda Y, Bando M, Ishii H, Miyazaki Y, Oshizawa A, Takemura T, Kawabata Y, Ogura T. Clinical characteristics of immunoglobulin G4-positive interstitial pneumonia. ERJ Open Reserch.2021; 7：00317-2021

12. Nozawa S, Urushihata K, Machida R, Hanaoka M. The positional characteristics of patients with obstructive sleep apnea:a single institute retrospective study in Japan. Sleep and Biological Rhythms.2021.

13. Morichika D, Taniguchi A, Oda N, Fujii U, Senoo S, Itano J, Kanehiro A, Kitaguchi Y, Yasuo M, Hanaoka M, Satoh T, Akira S, Kiura K, Maeda Y, Miyahara N. Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice. Respiratory Research. 2021；22

14. Araki T, Yamazaki Y, Goto N, Takahashi Y, Ikuyama Y, Kosaka M. Prognostic value of geriatric nutritional risk index for aspiration pneumonia: a retrospective observational cohort study. Aging Clinical and Experimental Research. 2021

15. Araki T, Tateishi K, Sonehara K, Hirota S, Komatsu M, Yamamoto M, Kanda S, Kuraishi H, Hanaoka M, Koizumi T. Clinical utility of the C-reactive protein:albumin ratio in non-small cell lung cancer patients treated with nivolumab. Thoracic Cancer. 2021；12（Issue5）：603-612

16. Kawabata H, Fujimoto S, Sakai T, Yanagisawa H, Kitawaki T, Nara K, Hagihara M, Yamamoto H, Tanimizu M, Kato C, Origuchi T, Sunami K, Sunami Y, Masunari T, Nakamura N, Kobayashi M, Yamagami K, Miura K, Takai K, Aoki S, Tsukamoto N, Masaki Y. Correction to: Patient’s age and D‑dimer levels predict the prognosis in patients with TAFRO syndrome. International Journal of Hematology. 2021；114：301-302

17. Kitaguchi Y, Fujimoto K, Droma Y, Yasuo M, Wada Y, Ueno F, Kinjo T, Kawakami S, Fukushima K, Hanaoka M. Automated Diseased Lung Volume Percentage Calculation in Quantitative CT Evaluation of Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. Journal of Computer Assisted Tomography.2021；45：649-658.

18. Araki T, Kitaguchi Y, Suzuki Y, Komatsu M, Sonehara K, Wada Y, Tateishi K, Hanaoka M. Prognostic implication of erector spinae muscles in non-small-cell lung cancer patients treated with immuno-oncology combinatorial chemotherapy. Thoracic Cancer. 2021 Nov;12(21):2857-2864.

19. Goto N, Wada Y, Ikuyama Y, Akahane J, Kosaka M, Ushiki A, Kitaguchi Y, Yasuo M, Yamamoto H, Matsuo A, Hachiya T, Ideura G, Yamazaki Y, Hanaoka M. The usefulness of a combination of age, body mass index, and blood urea nitrogen as prognostic factors in predicting oxygen requirements in patients with coronavirus disease 2019. Journal of Infection and Chemotherapy.2021 Dec;27(12):1706-1712.