|Associate Professor||MASUKI Shizue|
E-mail ： isports(at)shinshu-u.ac.jp
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The goal of our research is to provide countermeasures against global warming and aging society. Human beings have distributed widely over the earth since they were born 5 million years ago by their high abilities to move great distances in an upright position and to adapt to various severe environments. However, the recently developed amenity for air condition and motorization has deteriorated these abilities and accelerated the global warming by consuming huge amounts of natural energy resources to attain the amenity. Our challenge is to cut off this vicious cycle by re-activating the inborn abilities in human beings.In our laboratory, we have applied our laboratory achievements to the field and, inversely, picked up some novel ideas for the laboratory studies from the field. For the field, we have managed a health-promotion program for middle-aged and older people, called “Jukunen Taiiku Daigaku”, for these 11 years, in which 3,000 people participated. To reply to requests raised by the field, we have made a education program in a master course of Shinshu University Graduate School of Medicine since 2004 to produce talents who are able to contribute to health promotion in the aging society.
1) Blood pressure and thermal regulations during exercise in humans: We have studied the effects of acute dehydration on blood pressure and thermal regulations during exercise in humans. Also, we have developed regimens to increase exercise performance in a hot environment by maintaining blood volume by drinking sports drinks and by expanding blood volume by heat acclimatization and/or aerobic training..
2) Exercise training program for individuals to prevent lifestyle and age associated diseases: We have successfully accumulated a database of the effects of “high-intensity interval walking training” on physical fitness, blood pressure, and lifestyle-associated disease indexes in over 3,000 middle-aged and older people, which is used for make a training program fitted for individuals.
3) Search for genes activated by exercise in humans and animal models: We have studied blood pressure and metabolic regulations during exercise in mice deficient of some related genes. Based on these findings, we have compared the regulations among human subjects who have different single nucleotide polymorphisms of the genes and participate in the “Jukunen Taiiku Daigaku” program.
1. Masuki S, Sumiyoshi E, Koshimizu T, Qian J, Higuchi K, Tsujimoto G, and Nose H. Voluntary locomotion linked with cerebral activation is mediated by vasopressin V1a receptors in free-moving mice. J Physiol (Lond.) in press. Doi:10.1113/jphysiol.2013.251876
2. Kamijo Y, Ikegawa S, Okada Y, Masuki S, Okazaki K, Uchida K, Sakurai M, and Nose H. Enhanced renal Na+ reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men, Am J Physiol 303: R824-R833, 2012. DOI: 10.1152.ajpregu.00588.2011.
3. Kamijo Y, Okada Y, Ikegawa S, Okazaki K, Goto M, and Nose H. Skin sympathetic nerve activity component synchronizing with cardiac cycle is involved in hypovolemic suppression of cutaneous vasodilatation in hyperthermia. J Physiol Lond) 589: 6231-6242, 2011.
4. Morikawa M, Okazaki K, Masuki S, Kamijo Y, Yamazaki T, Gen-no H, and Nose H. Physical fitness and indices of . lifestyle-related diseases before and after interval walking training in middle-aged and older males and females. Br J Sports Med 45: 216-224, 2011.
5. Ikegawa S, Kamijo Y, Okazaki K, Masuki S, Okada Y, and Nose H. Effects of hypohydration on thermoregulation during exercise before and after 5-day aerobic training in a warm environment in young men. J Appl Physiol 110: 972-980, 2011.
6. Miyagawa K, Kamijo Y, Ikegawa S, Goto M, and Nose H. Reduced hyperthermia-induced cutaneous vasodilation and enhanced exercise-induced plasma water loss at simulated high altitude (3,200m) in humans. J Appl Physiol 110: 157-165, 2011.
7. Masuki S, Mori M, Tabara Y, Miki T, Morikawa M, Miyagawa K, Higuchi K, and Nose H for the Shinshu University Genetic Research Consortium. Vasopressin V1a receptor polymorphism and high-intensity interval walking training effects in middle-aged and older people. Hypertension 55: 747-754, 2010.
8. Goto M, Okazaki K, Kamijo Y, Ikegawa S, Masuki S, Miyagawa K, and Nose H. Protein and carbohydrate supplementation during 5-day aerobic training enhanced plasma volume expansion and thermoregulatory adaptation in young men. J Appl Physiol 109: 1247-1255, 2010.
9. Okazaki K, Ichinose T, Mitono H, Chen M, Masuki S, Endoh H, Hayase H, Tatsuya Doi T, and Nose H. Impact of protein and carbohydrate supplementation on plasma volume expansion and thermoregulatory adaptation by aerobic training in older men. J Appl Physiol 107: 725-733, 2009.
10. Masuki S and Nose H. Increased cerebral activity suppresses baroreflex control of heart rate in freely moving mice. J Physiol (Lond) 587: 5783-5794, 2009.