Kusano S, Kukimoto-Niino M, Akasaka R, Toyama M, Terada T, Shirouzu M,
Shindo T, Yokoyama S.
Crystal structure of the human receptor activity-modifying protein 1 extracellular domain.
Protein Sci. 17(11):1907-14. 2008
Kamiyoshi A, Sakurai T, Shindo Y. Iinuma N, Kawate H, Yoshizawa
T, Koyama T, Muto S, Shindo T.
Endogenous a-calcitonin gene-related peptide mitigates liver fibrosis in chronic hepatitis induced by repeated
administration of concanavalin A
Liver International (in press) 2008
Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.
Kruppel-like factor 5 causes
cartilage degradation through transactivation of matrix metalloproteinase 9.
J Biol Chem. 283(36):24682-9. 2008
Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate
H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo
T.
GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity.
J Clin Invest. 2008 Jan;118(1):29-39.
Yamamoto H, Nagase T, Shindo T, Teramoto S, Aoki-Nagase T, Yamaguchi Y,
Hanaoka Y, Kurihara H, Ouchi Y.
Adrenomedullin insufficiency increases allergen-induced airway hyperresponsiveness in mice.
J Appl Physiol. 102(6):2361-8.
2007.
Sakurai T, Kamiyoshi A, Watanabe S, Sato M, Shindo T.
Rapid
zygosity determination in mice by SYBR Green real-time genomic PCR of a crude
DNA solution.
Transgenic Res. 2008 Feb;17(1):149-55.
Nakanishi T,
Kumagai S, Kimura M, Watanabe H, Sakurai T, Kimura M, Kashiwabara S, Baba T.
Disruption of
mouse poly(A) polymerase mGLD-2 does not alter polyadenylation status in
oocytes and somatic cells.
Biochem Biophys
Res Commun. 2007;364:14-19.
Watanabe S, Misawa M, Matsuzaki T, Sakurai T, Muramatsu T, Yokomine T,
Sato M.
Production of characterization of transgenic mice systemically expressing
endo b-galactosidase C.
Glycobiology. 2008 Jan;18(1):9-19.
Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Fukuchi J, Kawate H, Muto S, Tagawa Y, Shindo T
Endogenous aCGRP protects against concanavalin A-induced hepatitis in mice
Biochem Biophys Res Commun.343(1):152-8. 2006
Takeda N, Manabe I, Shindo T, Iwata H, Iimuro S, Kagechika H, Shudo K,
Nagai R.
The synthetic retinoid Am80
reduces scavenger receptor expression and atherosclerosis in mice by inhibiting
IL-6
Arterioscler Thromb Vasc
Biol. 26(5):1177-83. 2006
Sato M, Sakurai T, Kiryu K, Takeda M, Yasuoka Y.
:
Folliculogenesis following syngeneic transplantation of young murine ovaries
into the testes.
Reprod. Med. Biol. 5, 71-77, (2006).
Watanabe S, Homma D, Furusawa T, Sakurai T, Sato M. :
Preparation of enzymatically active human Myc-tagged-NCre recombinase exhibiting
immunoreactivity with anti-Myc antibody.
Mol. Reprod. Dev. 73,1345-1352 (2006).
Sakurai T, Watanabe S, Kimura M, Sato M.
:
Strain difference in tolerance to low-temperature treatment of fertilized mouse oocytes.
Reprod. Med. Biol. 5,43-50, (2006).
Hasegawa K, Chuma S, Tada T, Sakurai T, Tamura M, Suemori H, Nakatsuji N.:
Testatin transgenic and knockout mice exhibit normal sex-differentiation.
Biochem Biophys Res Commun. 341, 369-375, (2006).
Nagai R, Suzuki T, Aizawa K, Shindo T, Manabe I.
Significance of the transcription factor KLF5 in
cardiovascular remodeling.
J Thromb Haemost. 3(8):1569-76. 2005.
Shindo T
Adrenomedullin Chapter 9: Knockout mice and transgenic mice
Kluwer academic press 167-174, 2005
Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, Nishimura G,
Maemura K, Yamauchi T, Kubota N, Suzuki R, Kitamura T, Akira S,
Kadowaki T, Nagai R.
Kruppel-like transcription factor KLF5 is a key regulator of
adipocyte differentiation
Cell Metabolism 1: 27-39, 2005
Fujiu K, Manabe I, Ishihara A, Oishi Y, Iwata H, Nishimura G, Shindo T, Maemura K, Kagechika H, Shudo K, Nagai R.
Synthetic Retinoid Am80 Suppresses Smooth Muscle Phenotypic Modulation and In-Stent Neointima Formation by Inhibiting KLF5.
Circ Res. 2005.
Iimuro S, Shindo T, Moriyama N, Amaki T, Niu P, Takeda N, Iwata H, Zhang Y, Ebihara A, Nagai R:
Angiogenic effects of adrenomedullin
in ischemia and tumor growth.
Circ Res
95:415-423, 2004
Niu P, Shindo
T, Iwata H, Iimuro S, Takeda N, Zhang Y, Ebihara A, Suematsu Y, Kangawa K,
Hirata Y, Nagai R:
Circulation 109:1789-1794,2004
Fukushima Y, Matsui T, Saitoh T, Ichinose M, Tateishi K, Shindo T, Fujishiro
M, Sakoda H, Shojima N, Kushiyama A, Fukuda S, Anai M, Ono H, Oka M, Shimizu
Y, Kurihara H, Nagai R, Ishikawa T, Asano T, Omata M.
Unique roles of G protein-coupled histamine H2 and
gastrin receptors in growth and differentiation of gastric mucosa.
Eur J Pharmacol. 502(3):243-52, 2004
Nagai R, Shindo T,
Manabe I, Suzuki T, Kurabayashi M.
KLF5/BTEB2, a Kruppel-like zinc-finger type transcription
factor, mediates both smooth muscle cell activation and cardiac hypertrophy.
Adv Exp Med Biol. 538:57-6, 2003
Niu P, Shindo T, Iwata H, Ebihara A, Suematsu Y, Zhang Y, Takeda N, Iimuro S, Hirata Y, Nagai R:
Accelerated cardiac hypertrophy and renal damage induced by angiotensin II in adrenomedullin knockout mice.
Hypertens Res 26: 731-736, 2003
Fukushima Y, Shindo T, Anai M, Saitoh T, Wang Y, Fujishiro M, Ohashi Y,
Ogihara T, Inukai K, Ono H, Sakoda H, Kurihara Y, Honda M, Shojima N, Fukushima
H, Haraikawa-Onishi Y, Katagiri H, Shimizu Y, Ichinose M, Ishikawa T,
Omata M, Nagai R, Kurihara H, Asano T: Structural and functional characterization
of gastric mucosa and central nervous system in histamine H(2) receptor-null
mice.
Eur J
Pharmacol 468(1):47-58, 2003
Kurihara
H, Shindo T, Oh-Hashi Y, Kurihar Y, Kuwaki T: Targeted disruption of
adrenomedullin and alphaCGRP genes reveals their distinct biological roles.
Hypertens Res 26 Suppl:S105-8, 2003
Nishimatsu
H, Hirata Y, Shindo T, Kurihara H, Suzuki E, Sata M, Satonaka H, Takeda R,
Nagata D, Kakoki M, Hayakawa H, Kangawa K, Matsuo H, Kitamura T, Nagai R :
Endothelial responses of the aorta from adrenomedullin transgenic mice and
knockout mice.
Hypertens
Res 26 Suppl: S79-84, 2003
Manabe I, Shindo T, Nagai R: Gene expression in fibroblasts and
fibrosis. Involvement in cardiac
hypertrophy.
Circ
Res 27:1103-1113, 2002
Niu P,
Shindo T, Ebihara A, Zhang Y, Kawanami D, Imai Y, Amaki T, Suematsu Y, Nagai R:
Protective effect of adrenomedullin against cardiac hypertrophy and renal
damage.
Journal
of Cardiac Failure 8, Suppl5: S221, 2002
Yokoyama
H, Wada T, Kobayashi K, Kuno K, Kurihara H, Shindo T, Matsushima K: A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1
null mutant mice develop renal lesions mimicking obstructive nephropathy.
Nephrol
Dial Transplant 17 Suppl 9:39-41, 2002
Aoki-Nagase
T, Nagase T, Oh-Hashi Y, Shindo T, Kurihara Y, Yamaguchi Y, Yamamoto H, Tomita
T, Ohga E, Nagai R, Kurihara H, Ouchi Y: Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient
mice.
Am J
Physiol Lung Cell Mol Physiol 283(5):L963-70, 2002
Shindo T,
Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama
N, Imai Y, Kawakami H, Nishimatsu H, Suzuki T, Morita H, Maemura K, Sata M,
Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R: Kruppel-like zinc-finger transcription factor
KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator
of cardiovascular remodeling.
Nature
Medicine 8(8):856-63, 2002
Imai
Y, Shindo T, Maemura K, Sata M, Saito Y, Kurihara Y, Akishita M, Osuga J,
Ishibashi S, Tobe K, Morita H, Oh-hashi Y, Suzuki T, Maekawa H, Kangawa K,
Minamino N, Yazaki Y, Nagai R, Kurihara H:
Resistance
to neointimal hyperplasia and fatty streak formation in adrenomedullin
overexpression mice.
Arterioscler Thromb Vasc Biol 22(8):1310-5, 2002
Fukino K, Suzuki T, Saito Y, Shindo T, Amaki T, Kurabayashi M, Nagai R:
Regulation of angiogenesis by the aging suppressor gene klotho.
Biochem
Biophys Res Commun 293:332-7, 2002
Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Kakoki
M, Nagata D, Hayakawa H, Satonaka H, Sata M, Tojo A, Suzuki E, Kangawa K,
Matsuo H, Kitamura T, Nagai R:
Circ Res 90:657-63, 2002
Shindo
T, Kurihara H, Maemura K, Kurihara Y, Ueda O, Suzuki H, Kuwaki T, Ju K-H, Wang
Y, Ebihara A, Nishimatsu H, Moriyama N, Fukuda M, Akimoto Y, Hirano H, Morita
H, Kumada M, Yazaki Y, Nagai R, Kimura K:
J.
Mol. Med 80(2):105-16, 2002
Imai
Y, Shindo T, Maemura K, Kurihara Y, Ryozo N, Kurihara H: Evidence
for the physiological and pathological roles of adrenomedullin from genetic
engineering in mice.
Ann N Y Acad Sci 947:26-33, 2001
Oh-hashi
Y,* Shindo T* (*double 1st author), Kurihara Y, Imai T, Wang Y,
Morita H, Imai Y, Kayaba Y, Nishimatsu H, Suematsu Y, Hirata Y, Yazaki Y, Nagai
R, Kuwaki T, Kurihara H: Elevated sympathetic nervous activity in
mice deficient in ?CGRP.
Circ
Res 89:983-90, 2001
Shindo
T, Kurihara Y, Nishimatsu H, Moriyama N, Kakoki M, Wang Y, Imai Y, Ebihara A,
Kuwaki T, Ju K-H, Minamino N, Kangawa K, Ishikawa T, Fukuda M, Akimoto Y,
Kawakami H, Imai T, Morita H, Yazaki Y, Nagai R, Hirata H, Kurihara H: Vascular
abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.
Circulation
104:1964-71, 2001
Imai
T, Morita T, Shindo T, Nagai R, Yazaki Y, Kurihara H, Suematsu M, Katayama S:
Vascular smooth muscle cell-directed overexpression of heme oxygenase-1
elevates blood pressure through attenuation of nitric oxide-induced
vasodilation in mice.
Circ
Res 89(1):55-62, 2001
Morita
H, Kurihara H, Yoshida S, Saito Y, Shindo T, Oh-Hashi Y, Kurihara Y, Yazaki Y,
Nagai R: Diet-induced hyperhomocysteinemia exacerbates neointima formation in
rat carotid arteries after balloon injury.
Circulation
103(1):133-9, 2001
Shindo
T, Kurihara H, Maemura K, Kurihara Y, Minamino N, Kangawa K, Yazaki Y, Nagai R:
Pathophysiological assessment of adrenomedullin by mice gene engineering
approach.
J
Submicroscopic Cytology & Pathology 32 (3):436, 2000
Shindo
T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, Imai T, WangY, Oh-hashi
Y, Morita H, Ishikawa T, Yazaki Y, Matsushima K: ADAMTS-1: A
metalloproteinase-disintegrin essential for normal growth, fertility, and organ
morphology and function.
J Clin
Invest 105(10):1345-52, 2000
Shindo
T, Kurihara H, Maemura K, Kurihara Y, Kuwaki T, Izumida T, Minamino N, Ju K,
Morita H, Oh-hashi Y, Kumada M, Kangawa K, Nagai R, Yazaki Y: Hypotension and
resistance to lipopolysaccharide-induced shock in transgenic mice
overexpressing adrenomedullin in their vasculature.
Circulation
101(19):2309-16, 2000
Imai
Y, Morita H, Kurihara H, Sugiyama T, Kato N, Ebihara A, Hamada C, Kurihara Y,
Shindo T, Oh-hashi Y, Yazaki Y: Evidence for association between paraoxonase
gene polymorphisms and atherosclerotic diseases.
Atherosclerosis
149(2):435-42, 2000
Morita H, Kurihara H, Kurihara Y,
Kuwaki T, Shindo T, Oh-hashi Y, Kumada M, Yazaki Y: Responses
of blood pressure and catecholamine metabolism to high salt loading in
endothelin-1 knockout mice.
Hypertens
Res 22(1):11-6, 1999
Morita
H, Kurihara H, Sugiyama T, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Yazaki
Y: Polymorphism of the methionine synthase gene : association with homocysteine
metabolism and late-onset vascular diseases in the Japanese population.
Arterioscler
Thromb Vasc Biol 19(2):298-302, 1999
Shindo
T, Kurihara H, Kurihara Y, Morita H, Yazaki Y: Upregulation of endothelin-1 and
adrenomedullin gene expression in the mouse endotoxin shock model.
J
Cardiovasc Pharmacol 31:S541-4, 1998
Shindo
T, Kurihara H, Ohishi N, Morita H, Maemua K, Kurihara Y, Tsuneyoshi H, Chi H,
Yamaoki K, Yazaki Y:
Circulation
97(13):1306-7, 1998
Morita
H, Kurihara H, Kurihara Y, Shindo T, Kuwaki T, Kumada M, Yazaki Y: Systemic and
renal response to salt loading in endothelin-1 knockout mice.
J
Cardiovasc Pharmacol 31:S557-60, 1998
Morita
H, Kurihara H, Tsubaki S, Sugiyama T, Hamada C, Kurihara Y, Shindo T, Oh-hashi
Y, Kitamura K, Yazaki Y:
Methylenetetrahydrofolate reductase gene polymorphism and ischemic
stroke in Japanese.
Arterioscler
Thromb Vasc Biol 18(9):1465-9, 1998
Morita
H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T,
Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yazaki Y:
Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a
risk factor for coronary artery disease.
Circulation
95(8):2032-6, 1997
Shindo
T, Ikeda U, Ohkawa F, Kawahara Y, Yokoyama M, Shimada K: Nitric oxide synthesis
in cardiac myocytes and fibroblasts by inflammatory cytokines.
Cardiovasc
Res 29(6):813-9, 1995
Shindo
T, Kuroda T, Watanabe S, Hojo Y, Sekiguchi H, Shimada K: Aneurysmal dilatation
of the pulmonary trunk with mild pulmonic stenosis.
Intern
Med 34(3):199-202, 1995
Shindo
T, Ikeda U, Ohkawa F, Takahashi M, Funayama H, Nishinaga M, Kawahara Y,
Yokoyama M, Kasahara T, Shimada K: Nitric oxide synthesis in rat cardiac
myocytes and fibroblasts.
Life
Sci 55(14):1101-8, 1994
Kagaya N,
Kamiyoshi A, Tagawa Y et al. In press.
Interaction of
rubratoxin B with serum albumin.
Kagaya N,
Kamiyoshi A, Tagawa Y et al. Micotxins In press.
Tumor necrosis-alpha is required for gastritis induced by Helicobacter
felis infection in mice.
Hasegawa
S, Nishikawa S, Miura T, Saito Y, Madarame H, Sekikawa K, Tagawa Y et al. Microb.
Pathog. 37:119-124, 2004
Comparative
Study on Adhesive Performance of Functional Monomers.
Yoshida,
Y., K. Nagakane, R. Fukuda, Y. Nakayama, M. Okazaki, H. Shintani, S. Inoue, Y.
Tagawa et al. J. Dental Research,
83:454-458, 2004
Liver protection by
bis(maltolato)zinc(II) complex.
Kawase, M., N. Kagaya, S.
Akamatsu, A. Kamiyoshi, S. Muto, Y. Tagawa, and Y. Yagi.: Exp. Anim. 53:1-9, 2004
Novel function of rare
catechin, epigallocatechin-3-(3’’-O-methyl)gallate, against cold injury in
primary rat hepatocytes.
Kagaya, N., Y. Hara, R. Saijo,
A. Kamiyoshi, Y. Tagawa et al. J.
Biosci. Bioeng. 96:559-563, 2003
Airway IgG counteracts specific and bystander allergen-triggered
pulmonary inflammation by a mechanism dependent on FcgR and IFN-g.
Sehra, S., Pynaert, G.., Tournoy, K., Haegenman, A., Matthys, P.,
Tagawa, Y. et al. J. Immunol., 171:2080-2089
Survival and function of mouse embryonic stem cell-derived
cardiomyocytes in ectopic transplants.
Johkura, K., Cui, L., Suzuki, A., Teng, R., Kamiyoshi, A.,
Okamura, S., Kubota, S., Zhao, X., Asanuma, K., Okouchi, Y., Ogiwara, N.,
Tagawa, Y. et al.: Cardiovascular
Research 58:435-443, 2003
Differences between BALB/c and C57BL/6 in mouse hepatitis virus
replication in primary hepatocyte culture.
Kyuwa, S., Kawamura, S., Tagawa, Y. et al.: Exp. Anim., 52:81-84, 2003
IL-1-induced tumor necrosis factor-? elicits inflammatory cell
infiltration in the skin by inducing IFN-g-inducible
protein 10 in the elicitation phase of the contact hypersensitivity response.
Nakae, S., Komiyama, Y., Narumi, S., Sudo, K., Horai,
R., Tagawa, Y. et al.: Int. Immunol. , 15: 251-260, 2003
Suppression of cytotoxin-induced cell death in isolated
hepatocytes by tea catechins.
Kagaya, N., Tagawa, Y. et al. : Eur. J. Pharmacol. 450: 231-236, 2002
Inhibition of B16 melanoma
metastasis by interferon-gamma through direct inhibition of cell proliferation
and activation of anti-tumor host mechanisms.
Kakuta,
S., Tagawa, Y. et al.: Immunology. 105: 92-100, 2002
Comparison of host resistance to primary and secondary Listeria
monocytogenes infections in mice by intranasal and intravenous routes.
Mizuki, M., Nakane, A., Sekikawa, K., Tagawa, Y. et al.: Infect. Immun. 70:4805-4811, 2002
Roles of gamma interferon and tumor necrosis factor-alpha in shiga
toxin lethality.
Sasaki, S., Omoe, K., Tagawa, Y. et al.: Microbial Pathogenesis. 33: 43-47, 2002.
Acute hepatic failure in IFN-g-deficient BALB/c mice after murine coronavirus
infection.
Kyuwa,
S., Shibata, S., Tagawa, Y. et al.: Virus Res.
83: 169-177, 2002.
Enhancing effect of zinc on hepatoprotectivity of epigallocatechin
gallate in isolated rat hepatocytes.
Kagaya, N., Kawase, M., Maeda, H., Tagawa, Y. et al.: Biol.Pharm.Bull. 25: 1156-1160, 2002.
Effect of 6-hydroxydopamine on host
resistance against Listeria monocytogenes infection.
Miura, T., Kudo, T., Matsuki, A.,
Sekikawa, K., Tagawa, Y. et al.:
Infect. Immun. 69:7234-7241,
2001
Organ
infectivity of Toxoplasma gondii in interferon-gamma knockout mice.
Norose, K., Mun, H. S., Aosai, F., Chen, M., Hata, H., Tagawa, Y. et al.: J.
Parasitol. 87:447-452,
2001
A critical role of Fc receptor-mediated antibody-dependent phagocytosis
in the host resistance to blood-stage plasmodium berghei XAT Infection.
Yoneto,
T., Waki, S., Takai, T., Tagawa, Y. et al.: J.
Immunol. 166: 6236-6241, 2001
The
severity of hepatic lesion after intraperitoneal JHMV infection in IFN-gamma
deficient mice is parallel to viral replication in hepatocytes in vitro.
Kyuwa
S, Kawamura S, Shibata S, Machii K, Tagawa Y. et al.:
Adv Exp Med Biol. 494:95-99, 2001
Bimodal
role of endogenous interleukin-6 in concanavalin A-induced hepatitis in mice.
Tagawa, Y. et al.:
J. Leukoc. Biol. 67:90-96, 2000
Lipopolysaccharide-induced
HIV-1 expression in transgenic mice is mediated by tumor necrosis factor-α and
interleukin-1, but not by interferon-g nor
interleukin-6.
Tanaka,
J., H. Ozaki, J. Yasuda, R. Horai, Y. Tagawa. et al.:
AIDS 14:1299-1307, 2000
Sasaki,
S., S. Nishikawa, T. Miura, M. Mizuki, K. Yamada, H. Madarame, Y. Tagawa, Y.
Iwakura, and A. Nakane. : Interleukin-4 and interleukin-10 are involved in host
resistance to Staphylococcus aureus infection through regulation of gamma
interferon. Infect. Immun. 68:2424-2430, 2000
Roles
of endogenous cytokines in liver apoptosis of mice in lethal Listeria
monocytogenes infection.
Miura,
T., S. Nishikawa, S. Sasaki, K. Yamada, S. Hasegawa, D. Mizuki, M. Mizuki, I.
Hatayama, K. Sekikawa, Y. Tagawa, Y. et al.: FEMS Immunol. Med. Microbiol. 28:335-341,
2000
Toxoplasma
gondi Hsp 70 as a danger signal in tosoplasma gondi-infected mice.
Mun
H. S., F. Aosai, K. Norose, M. Chen, H. Hata, Y. Tagawa, Y. et al.: Cell stress Chaperones. 5: 328-335, 2000
Interferon-g priming is not critical for IL-12 production of
murine spleen cells.
Hino, A., O. Igarashi, Y. Tagawa, Y. et al.:
Cytokine. 12:12-20, 2000
Hematological
characteristics of rats spontaneously developing eosinophilia.
Matsumoto,
K., N. Matsushita, H. Tomozawa, and Y. Tagawa.
Exp.
Anim. 49:211-215, 2000
