Plasma IL-6
Response with Paraplegia During a Wheelchair Half-Marathon Race
Yusuke
Sasaki, Makoto Ide, Motohiko Banno, Takashi Kawasaki, Yasunori Umemoto, Nami
Kanno, Masaki Goto, Ken Koda, Tomoyuki Ito, and Fumihiro Tajima
Department of
Rehabilitation,
Objective:
This study investigated the responses of Interleukin (IL)-6 in athletes with
spinal cord injury (SCI) during and after a wheel chair half-marathon race.
Subjects:
Twelve male wheelchair racers with SCI (spinal lesion between T4 and L1).
Setting:
Field works in the half-marathon division of the 2008 Oita International
Wheelchair Marathon Race.
Method: IL-6,
Tumor necrosis factor (TNF)-α,
Epinephrine, Cortisol, and Monocyte were measured in participants of the race.
Blood samples were obtained the day before, immediately after, and 2 hours
after the race.
Result: The
plasma concentration of TNF-α, Epinephrine
and Cortisol increased (P<0.05) immediately after the race and returned to
the control level within 2 hours. The number of circulating Monocyte increased
(P<0.05) immediately after and 2 hours after the race compared with the day
before. IL-6 increased (P<0.05) from 1.4±3.7pg/ml (mean ± SD) to
11.7±6.5pg/ml immediately after the race and decreased (P<0.05) to
4.0±2.6pg/ml 2 hours after.
Conclusion:
The present study demonstrated that even upper arm wheelchair sports induced
increases of IL-6. It was suggested that the severe stress of the half-marathon
race induced a significant increase in plasma cortisol level immediately after
the race. These data suggested that circulating monocyte are not the source of
elevated levels of plasma IL-6 and TNF-αafter the
race, since their changes were not related.
Although wheel chair racers run involving a limited muscle mass, the muscle
released the sufficient amount of IL-6.
Key word: Interleukin-6, wheel chair racers,
exercise