Publication

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Most recent papers

Suzuki T, Kametani K, Guo W and Li W (2018) Protein components of postsynaptic density lattice, a backbone structure for type I excitatory synapses. J. Neurochem. 144: 390-407. DOI:10.1111/jnc.14254

 

Shirai Y, Li W and Suzuki T (2017) Role of splice variants of Gtf2i, a transcription factor localizing at postsynaptic sites, and its relation to neuropsychiatric diseases. Int. J. Mol. Sci. 2017, 18, 411;

doi:10.3390/ijms18020411 (invited review).

 

Guo W, Liu Q, and Suzuki T (2017) Protein components of the backbone structure of PSDs of type I excitatory synapses. Shinshu Med. J. 65: 211-224.

 

Tanahashi, H., Tian, Q. B., Hara, Y., Sakagami, H., Endo, S. and Suzuki, T. (2016) Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance. Sci. reports, 6, 20241. DOI: 10.1038/srep20241

 

Yoshinori Shirai, Masahiko Watanabe, Hiroyuki Sakagami and Tatsuo Suzuki (2015) Novel splice variants in the 5’UTR of Gtf2i expressed in the rat brain: alternative 5’UTRs and differential expression in the neuronal dendrites. J. Neurochem. 134: 578-589

 

LiYing Zhao, Hiroyuki Sakagami and Tatsuo Suzuki (2014) Detergent-dependent separation of postsynaptic density (PSD), membrane rafts and other subsynaptic structures from the synaptic plasma membrane of rat forebrain. J. Neurochemistry 131: 147-162

 

Suzuki T and Yao WD (2014) Molecular and Structural Bases for Postsynaptic Signal Processing and Synaptic Plasticity: Postsynaptic density (PSD) and Postsynaptic Membrane Rafts (PSR). J. Neurorestoratology 2:1-14. (Online open on Dec. 9, 2013, at http://www.dovepress.com/articles.php?article_id=15233) Invited Review

 

 

Original papers (1995~)

LiYing Zhao, Hiroyuki Sakagami and Tatsuo Suzuki (2014) Detergent-dependent separation of postsynaptic density (PSD), membrane rafts and other subsynaptic structures from the synaptic plasma membrane of rat forebrain. J. Neurochem. 131: 147-162

 

Qian Liu, Wei-Dong Yao and Tatsuo Suzuki (2013) Specific interaction of postsynaptic densities with membrane rafts isolated from synaptic plasma membranes. J Neurogenetics 27:43-58

 

Mizuno M, Kato D, Kanamori T, Toyoda T, Suzuki T, Ojika K, Matsukawa N (2013) Phosphorylation of collapsin response mediator protein-2 regulates its localization and association with hippocampal cholinergic neurostimulating peptide precursor in the hippocampus. Neurosci. lett. 535:122-127.

Nisimaru N, Mittal C, Shirai Y, Sooksawate T, Anandaraj P, Hashikawa T, Nagao S, Arata A, Sakurai T, Yamamoto M, Ito M. (2013) Orexin-neuromodulated cerebellar circuit controls redistribution of arterial blood flows for defense behavior in rabbits. Proc. Natl. Acad. Sci. USA 110:14124-14131.

Kato D, Mitake S, Mizuno M, Kanamori T, Suzuki T, Ojika K, Matsukawa N (2012) Co-localization of hippocampal cholinergic neurostimulating peptide precursor with collapsin response mediator protein-2 at presynaptic terminals in hippocampus. Neurosci. Lett. 517, 92–97.

 

Tatsuo Suzuki, Jingping Zhang, Shoko Miyazawa, Qian Liu, Michael R. Farzan, Wei-Dong Yao (2011) Association of Membrane Rafts and Postsynaptic Density: Proteomics, Biochemical, and Ultrastructural Analyses.

J. Neurochem. 119: 64-79.

PMID: 21797867

 

Fukaya M, Kamata A, Hara Y, Tamaki H, Katsumata O, Ito N, Takeda S, Hata Y, Suzuki T, Watanabe M, Harvey RJ and Sakagami HCA (2011) SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at postsynaptic specializations of inhibitory synapses. J. Neurochem. 116,1122-1137

 

Tanahashi, H., Kito, K., Ito, T., and Yoshioka, K. (2010) MafB protein stability is regulated by the JNK and ubiquitin-proteasome pathways. Arch. Biochem. Biophys. 494, 94-100.

PMID: 19932079

 

Tung Dinh Le, Yoshinori Shirai, Takehito Okamoto, Tetsuya Tatsukawa, Soichi Nagao, Takao Shimizu, and Masao Ito (2010) Lipid signaling in cytosolic phospholipase A2α-cyclooxygenase-2 cascade mediates cerebellar long-term depression and motor learning. Proc. Natl. Acad. Sci. USA 107, 3198-3203.

PMID: 20133605

 

Kathryn A. Skelding, Tatsuo Suzuki, Sarah Gordon, Jing Xue, Nicole M. Verrills, Phillip W. Dickson, John A.P. Rostas (2010) Regulation of CaMKII by Phospho-Thr253 or Phospho-Thr286 Sensitive Targeting Alters Cellular Function. Cellular Signalling 22, 759-769

PMID: 20060891

 

Sakagami H, Sanda M, Fukaya M, Miyazaki T, Sukegawa J, Yanagisawa T, Suzuki T, Fukunaga K, Watanabe M, Kondo H. (2008) IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses. Neurosci. Res. 60:199-212.

PMID: 18164504

 

Il Soo Moon, Hiroyuki Sakagami, Jun Nakayama and Tatsuo Suzuki (2008) Differential distribution of synGAPa1 and synGAPb isoforms in rat neurons. Brain Res. 1241 62-75.

PMID: 18824155

 

Nonaka H, Takei K, Umikawa M, Oshiro M, Kuninaka K, Bayarjargal M, Asato T, Yamashiro Y, Uechi Y, Endo S, Suzuki T, Kariya K (2008) MINK as a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. Biochem. Biophys. Res. Commun. 377, 573-578.

PMID: 18930710

 

Tanahashi H, Yoshioka K (2008) RNA interference silencing of DRAL affects processing of amyloid precursor protein. Neurosci. Lett. 439 293-297.

PMID: 18534756

 

Zhang B, Luo S, Wang Q, Suzuki T, XiongW-C, Mei L (2008) LRP4 serves as a co-receptor of agrin. Neuron 60, 285-297.

PMID: 18957220

 

Suzuki T, Tian Q-B, Kuromitsu J, Kawai T, and Endo S (2007) Characterization of mRNA species that are associated with postsynaptic density fraction by gene chip microarray analysis. Neurosci. Res. 57: 61-85.

PMID: 17049655

 

Zisman S, Marom K, Avraham O, Rinsky-Halivni L, Gai U, Kligun G, Tzarfaty-Majar V, Suzuki T & Klar A (2007) Proteolysis and membrane capture of F-spondin generate combinatorial guidance cues from a single molecule. J. Cell Biol. 178: 1237-1249.

PMID: 17875744

 

Terada N, Ohno N, Saitoh S, Seki G, Komada M, Suzuki T, Yamakawa H, Soleimani M and Ohno S (2007) Interaction of Membrane Skeletal Protein, Protein 4.1B and p55, and Sodium-Bicarbonate Cotransporter1 in Mouse Renal S1-S2 Proximal Tubules. J. Histochem. Cytochem. 55: 1199-1206.

PMID: 17712176

 

Lu Y, Tian QB, Endo S and Suzuki T (2007) LRP4 may play a role in maintenance of synaptic integrity and neuronal cell survival through apoE/cholesterol. Brain Res. 1177: 19-28.

PMID: 17889837

 

Suzuki T, Du F, Tian QB, Zhang JP and Endo S (2007) CaM kinase IIα clusters are associated with stable lipid rafts and their formation traps PSD-95.　J. Neurochem. 104: 596-610.

PMID: 18005004

 

Tian Q-B, Suzuki T, Yamauchi T, Sakagami H, Yoshimura Y, Miyazawa S, Nakayama K, Saitoh F, Zhang J-P, Kondo H and Endo S (2006) Interaction of LDL receptor-related protein 4 (LRP4) with postsynaptic scaffold proteins via its C-terminal PDZ domain-binding motif, and its regulation by Ca2+/calmodulin-dependent protein kinase II. Eur. J. Neurosci. 23: 2864-2876. 

PMID: 16819975

 

Feng Du, Fuminori Saitoh, Qing-Bao Tian, Shoko Miyazawa, Shogo Endo, Tatsuo Suzuki (2006) Mechanisms for association of Ca2+/calmodulin-dependent protein kinase II with lipid rafts. Biochem Biophys. Res. Commun. 347: 814-820.

PMID: 16872923

 

Suzuki T., Li W., Zhang J-P., Qin Tian Q-B., Sakagami H., Usuda N., Kondo H., Fujii T. and Endo S. (2005) A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), form a multi-protein complex with various postsynaptic density proteins. Eur. J. Neurosci. 21: 339-350.

PMID: 15673434

 

 Wang X, Tian Q-B, Okano A, Sakagami H, Moon I-S, Kondo H, Endo S, and Suzuki T. (2005) BAALC 1-6-8 protein is targeted to postsynaptic lipid raft by its N-terminal myristoylation and palmityolation, and interacts with a, but not b, subunit of Ca2+/calmodulin-dependent protein kinase II. J. Neuorochem. 92: 647-659.

PMID: 15659234

Zhang J-P., Tian Q-B., Sakagami H., Kondo H., Endo S. and Suzuki T (2005) p55 protein is a member of PSD scaffold proteins in the rat brain and interacts with various PSD proteins. Mol. Brain Res. 135: 204-216.

PMID: 15857683

 

Inaba Y., Tian Q-B., Okano A., Zhang J-P., Sakagami H., Miyazawa S, Li W., Komiyama A., Inokuchi K., Kondo H., and Suzuki T. (2004) Brain-specific potential guanine nucleotide exchange factor for Arf, synArfGEF(Po), is localized to postsynaptic density. J. Neurochem. 89: 1347-1357.

PMID: 15189337

 

Saitoh F., Tian Q-B, Okano A., Sakagami H, Kondo H. and Suzuki T. (2004) NIDD, a novel DHHC-containing protein, targets neuronal nitric oxide synthase (nNOS) to the membrane through a PDZ-dependent interaction and regulates nNOS activity. J. Biol. Chem. 279: 29461-29468.

PMID: 15105416

 

Okano A., Usuda N., Furihata K., Nakayama K., Tian Q-B. and Okamoto T. and Suzuki T. (2003) Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is localized in the postsynaptic regions Brain Res. 967: 210-225.

PMID: 12650982

 

Asaki C, Usuda N, Nakazawa A, kametani K, and Suzuki T (2003) Localization of translational components at postsynaptic sites of the rat brain (submitted). Brain Res. 972:168-176.

PMID: 12711090

 

Tian QB, Okano A, Nakayama K, Miyazawa S, Shogo Endo, and Suzuki T (2003) A novel ubiquitin-specific protease, synUSP, is localized at the post-synaptic density and post-synaptic lipid raft. J. Neurochem. 87: 665-675.

PMID: 14535949

 

Konno D, Ko JA, Usui S, Hori K, Maruoka H, Inui M, Fujikado T, Tano Y, Suzuki T, Tohyama K and Sobue K (2002) The postsynaptic density and dendritic raft localization of PSD-Zip70, which contains an N-myristoylation sequence and leucine-zipper motifs. J Cell Sci. 115: 4695-4706.

PMID: 12415013

 

Li W, Okano A, Tian QB, Nakayama K, Furihata T, Nawa H, and Suzuki T (2001) Characterization of a novell synGAP isoform, synGAP-b.  J Biol. Chem. 276: 21417-21424.

PMID: 11278737

 

Suzuki T, Ito J, Takagi H, Saitoh F, Nawa H, and Shimizu H. (2001) Biochemical evidence for localization of AMPA-type glutamate receptor subunits in the dendritic raft. Mol. Brain Res. 2001, 89:20-28.

PMID: 11311972

 

Murata S, Usuda N, Okano A, Kobayashi S, and Suzuki T. (2000) Occurrence of a transcription factor, signal transducer and activators of transcription 3 (Stat3), in the postsynaptic density of the rat brain. Mol. Brain Res. 78: 80-90.

PMID: 10891587

 

Suzuki T, Usuda N, Murata S, Nakazawa A, Ohtsuka K, and Takagi H (1999) Presence of molecular chaperones, heat shock cognate (Hsc) 70 and heat shock protein (Hsp) 40, in the postsynaptic structures of rat brain. Brain Res. 816: 99-110.

PMID: 9878698

 

 Tian QB, Nakayama K, Okano A, and Suzuki T (1999) Identification of mRNAs localizing in the postsynaptic region. Mol. Brain Res. 72: 147-157.

PMID: 10529473

 

Suzuki T, Mitake S, Murata S. (1999) Presence of up-stream and down-stream components of mitogen-activated protein kinase (MAPK) pathway in the PSD fraction of the rat forebrain. Brain Res. 840:36-44.

PMID: 10517950

 

 

Suzuki T, Usuda N, Ishiguro H, Mitake S, Nagatsu T, and Okumura-Noji K (1998) Occurrence of a transcription factor, cAMP response element-binding protein (CREB), in the postsynaptic sites of the brain. Mol. Brain Res. 61: 69-77.

PMID: 9795144

 

Suzuki T, Mitake S, Okumura-Noji K., Shimizu H, Tada T, and Fujii T (1997) Localization of a-internexin in the postsynaptic density of the rat brain. Brain Res. 765: 74-80.

PMID: 9310396

 

Suzuki T, Mitake S, Okumura-Noji K, Yang J-P, Fujii T and Okamoto T (1997) Presence of NF-kB-like and IkB-like immunoreactivities in postsynaptic densities. Neuroreport 8: 2931-2935.

PMID: 9376533

 

Suzuki T and Okumura-Noji K (1995) NMDA receptor subunits e1 (NR2A) and e2 (NR2B) are substrates for Fyn in the postsynaptic density fraction isolated from the rat brain. Biochem. Biophys. Res. Commun. 216, 582-588.

PMID: 7488151

 

 

Publication (~ 1995)

Suzuki T, Fujii T, and Tanaka R (1987) Independent protein kinases associated with rat cerebral synaptic junction: comparison with cyclic AMP-dependent and Ca2+/calmodulin-dependent protein kinases in synaptic junction. J. Neurochem. 48: 1716-1724.

PMID: 3033148

 

Suzuki T and Siekevitz P (1989) Properties of a protein kinase C activity in synaptic plasma membrane and postsynaptic density fractions isolated from canine cerebral cortex. J. Neurochem. 53: 1751-1762.

PMID: 2509635

 

 

Suzuki T, Okumura-Noji K, Ogura A, Kudo Y, and Tanaka R (1992) Antibody reacting specifically to the Thr-286-autophosphorylated a-subunit of the Ca2+/calmodulin-dependent protein kinase II. Proc. Natl. Acad. Sci. USA 89: 109-113.

PMID: 1309602

 

Suzuki T, Okumura-Noji K, Tanaka R, and Tada T (1994) Rapid translocation of a-subunit of cytosolic Ca2+/calmodulin-dependent protein kinase II to particulate fraction after decapitation. J. Neurochem. 63, 1529-1537.

PMID: 7931307

 

Xiao R-P, Cheng H, Ledere WJ, Suzuki T, and Lakatta EG (1994) Dual regulation of Ca2+/calmodulin-dependent kinase II activity by membrane voltage and by Ca2+ influx. Proc. Natl. Acad. Sci. USA 91, 9659-9663.

 

Olson NJ, Masse T, Suzuki T, Chen J, Alam D, Kelly PT (1995) Functional identification of the promoter for the gene encoding the alpha subunit of calcium/calmodulin-dependent protein kinase II. Proc. Natl. Acad. Sci. USA 92:1659-1663.

 

 

Review etc

Suzuki T (1996) Messengers from the synapse to the nucleus (MSNs) that establish late phase of long-term potentiation (LTP) and long-term memory.　 Neurosci. Res. 25: 1-6 (invited review).

PMID: 8808794

 

鈴木龍雄 (1996) シナプス可塑性の分子基盤 - PSDタンパク質 - . 日本神経精神薬理学雑誌 16: 53-58.　PMID: 8905791

 

鈴木龍雄 (1996) 記憶・学習の分子機構：長期増強をモデルとして，信州医学会誌 44: 395-404

 

鈴木龍雄 (1997) シナプスのMAPキナーゼ系, 生体の科学 48: 97-100.

 

鈴木龍雄 (1997) 海馬での長期増強(LTP)/長期抑圧(LTD), Bio Science 用語ライブラリー：脳・神経，御子柴克彦 編 (羊土社)

 

Ohtsuka K and Suzuki T (2000) Roles of molecular chaperones in the nervous system. Brain Res. Bulletin 53: 141-146 (invited review).

PMID: 11044589

 

鈴木龍雄 (2001) 脳の可塑性を考える．基礎老化研究 25. 126-128.

 

鈴木龍雄 (2002) シナプス後部におけるシグナルプロセッシングの分子基盤. 　生体の科学　53: 157-162.

 

Suzuki T (2002) Lipid rafts at the postsynaptic sites: distribution, function and linkage to postsynaptic density (PSD). Neurosci. Res. 44: 1-9 (invited review).

PMID: 12204288

 

鈴木龍雄　(2004) 新規PSDタンパク質の同定と脳疾患への関与を探る．日本 神経精神薬理学雑誌 24: 205-210.　PMID: 15484821 

 

鈴木龍雄 (2005)シナプス分子と精神・神経疾患. 基礎老化研究 29: 11-15

 

鈴木龍雄，Chiye Aoki (2007) シナプス構築におけるMAGuKファミリータンパク質p55の関与．生体の科学 58: 108-112.

 

鈴木龍雄 (2010) シナプス形成におけるLRP4シグナリングの関与. 生体の科学 61 (in press)

 

鈴木龍雄 (2010) synGAPアイソフォームの機能分化. 生体の科学 61 (in press)

 

鈴木龍雄 (2010) TANC1：スパインサイズ制御系との関連. 生体の科学 61 (in press)

 

鈴木龍雄 (2010) 脳では未開拓のmultivalent scaffolding protein,p55. 生体の科学 61 (in press)

 

鈴木龍雄 (2010) BAALC1-6-8 proteinはカルモジュリンキナーゼαsubunitのターゲッティングに関与する？ 生体の科学 61 (in press)

 

Suzuki, T. (2010) Isolation of synapse-subdomains by subcellular fractionation using sucrose density gradient centrifugation.  Neuroproteomics in the series “Neuromethods” from Humana Press (Springer Protocols). 

 

Suzuki T and Yao WD (2014) Molecular and Structural Bases for Postsynaptic Signal Processing and Synaptic Plasticity: Postsynaptic density (PSD) and Postsynaptic Membrane Rafts (PSR). J. Neurorestoratology, 2:1-14. (Online open on Dec. 9, 2013, at http://www.dovepress.com/articles.php?article_id=15233)

Invited Review

 

 

Journal cover

Suzuki T, Usuda N, Ishiguro H, Mitake S, Nagatsu T, and Okumura-Noji K (1998) Occurrence of a transcription factor, cAMP response element-binding protein (CREB), in the postsynaptic sites of the brain. Mol. Brain Res. 61: 69-77.

PMID: 9795144

 

 

Fig. 4 in Suzuki T (2002) Lpid rafts at the postsynaptic sites: distribution, function and linkage to postsynaptic density (PSD). Neurosci. Res. 44: 1-9

PMID: 12204288

 

　Fig. 7 in Lu Y, Tian QB, Endo S and Suzuki T (2007) LRP4 may play a role in maintenance of synaptic integrity and neuronal cell survival through apoE/cholesterol. Brain Res. 1177: 19-28.

PMID: 17889837

 

 

 

Genes registered

1. AB040815: ninjurin, 08-APR-2000（main contributor, by 李衛東）

2. AB016962: synGAP-d, 01-SEP-2000（by 李衛東）

3. AB055628: rROK1L (ROK1-like protein), 10-FEB-2001（by 李衛東）

4. AB005052: rHIP1R (rat huntingtin-interacting protein 1-related, 20-FEB-2001)

5. AB057643: synGEF-ARF (by 稲葉雄二)

6. AB067572: rat lysophosphatidic acid acyltransferase-delta, 31-Jul-2001 (A20-, by 李衛東)

7. AB073317: LRP4 (ssLRP (synaptic LDL receptor-related protein, Dem26), 19-Oct-2001（by 田慶宝）

8. AB073318: BAALC1-6-8, 19-Oct-2001 (Dem-A20-4) (by 王新),

9. AB073880: synUSP (synaptic ubiquitin-specific protease, Dem21 2-Nov-2001（by 田慶宝）

10.AB098073: p55, 14-Dec-2002 (C20-1) (by 張 静萍)

11.AB098072: TANC, 14-Dec-2002（by 李衛東）

12. AB098078: NIDD-Lおよび S, 16-Dec-2002, (A20-5)(by 斉藤文典)

13. AB176831: rat NOS3 (eNOS) 09-Apr-2004 (by 斎藤文典)

14. AB186051: Ufc1 (Umf1 conjugating enzyme 1) 30-July-2004, (A1-2) (by 田澤　茂)

15. BAD95468: NOD3-like protein 7-April-2005 (by Lu Yanghao)

 

16. BAD95469: RabGAP (Po) 7-April-2005 (by Lu Yanghao)

17. AB441169: Ufc1, short form 16-June-2008 (by 田澤　茂)

18. Hypoxia-inducible factor1, alpha subunit (HIF1A), variant K12NR (by Tanahashi)

 

 

Patent application (accumulated)

1. 脳に存在するユビキチン特異的プロテアーゼ及びそれをコードするDNA．鈴木龍雄，田　慶宝　（特願2001-330339, 平成13年10月29日 出願)

2. 同上，海外特許申請

3. 白血病診断剤，白血病診断キット，白血病診断方法，及び白血病診断装置 (米国特許出願　 L0400008, 平成16年9月16日出願)

 

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