2010.12.9 updated

Schmelzer C, Okun J, Haas D, Higuchi K, Sawashita J, Mori M, Doring F. The reduced form of Coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice. IUBMB Life 2010 62(11):812-818.

Qian J, Yan J, Ge F, Zhang B, Fu X, Tomozawa H, Sawashita J, Mori M, Higuchi k. Mouse senile amyloid fibrils deposited in skeletal muscle exhibit amyloidosis-enhancing activity. PLoS Pathogens 6(5):e1000914 (Epub 2010 May 20).

Zhang P, Fu X, Sawashita J, Yao J, Zhang B, Qian J, Tomozawa H, Mori M, Ando Y, Naiki H, Higuchi K. Mouse model to study human Aβ2M amyloidosis: Generation of a transgenic mouse with excessive expression of human β2-microglobulin. Amyloid 17(2):50-62

Tomozawa H, Nishio A, Okuhara U, Higuchi K, Matsumoto K, Mori M. BN.MES-Cybames congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia. Exp Animal 59(4):469-478

Okudaira S, Shimizu M, Otsuki B, Nakanishi R, Ohta A, Higuchi K, Hosokawa M, Tsuboyama T, Nakamura T. Quantitative trait locus on chromosome X affects bone loss after maturation in mice. J Bone Miner Metab Epub 2010 Mar 31.

Nakajima K, Takeoka M, Mori M, Hashimoto S, Sakurai A, Nose H, Higuchi K, Itano N, Shiohara M, Oh T, Taniguchi S. Exercise effects on methylation of ASC gene. Int J Sports Med 31(9):671-675. Epub 2010 Mar 3.

Masuki S, Mori M, Tabara Y, Miki T, Sakurai A, Morikawa M, Miyagawa K, Higuchi K, Nose H, Shinshu University Genetic Research Consortium. Vasopressin V1a receptor polymorphism and interval walking training effects in middle-aged and older people. Hypertension 55(3):747-754.

Chambers JK, Kanda T, Shirai A, Higuchi K, Ikeda SI, Une Y. Senile systemic amyloidosis in an aged savannah monkey (Cercopithecus aethiops) with tenosynovial degeneration. J Vet Med Sci 72(5):657-659. Epub 2010 Jan 15.

＜学会賞受賞＞ 銭 金澤。「マウス老化アミロイドーシスにおける熱ストレス反応の役割：HSF1ノックアウトを用いた解析」（日本基礎老化学会第33回大会若手奨励賞 (40才以下の筆頭発表者に対する優秀発表賞) 2010.6.18)　

（2009年）

Schmelzer C, Kubo H, Mori M, Sawashita J, Kitano M, Hosoe K, Boomgaaden I, Doring F, Higuchi K. Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a PPAR-α gene expression signature in SAMP1 mice. Mol Nutr Food Res 2010 54(6):805-815. Epub 2009 Dec 3.

Mori M, Higuchi K, Sakurai A, Tabara Y, Miki T, Nose H. Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases. J Physiol 587: 5577-8554. Epub 2009 Sep 7.

Sawashita J, Onitsuka S, Gen-no H, Ishikawa S, Iino F, Tateishi N, Murakami T, Seki Y, Nagaiwa T, Hanaoka M, Hama S, Nose H, Higuchi K. Effects of mild calorie restriction and high-intensity interval walking in middle-aged and older overweight Japanese. Exp Gerontol 44(10): 666-675. Epub 2009 Jul 26.

Sawashita J, Kametani F, Hasegawa K, Tsutsumi-Y S, Zhang B, Yan J, Mori M, Naiki H, Higuchi K. Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II. Biochim Biophys Acta -Proteins & Proteomics 1794(10):1517-1529. Epub 2009 Jul 10.

Mori M, Li G, Hashimoto M, Nishio A, Tomozawa H, Suzuki N, Usami S, Higuchi K, Matsumoto K. Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba). J Luek Biol 86(3):473-478. Epub 2009 Apr 30.

Zhang G, Fu X, Takeda T, Higuchi K, Mori M. Dysfunction in ABCB1A has only a weak effect on susceptibility to dextran sulfate sodium-induced colitis in SAM strains. Exp Anim 58(4):421-425.

Mori M, Fu X, Chen L, Zhang G, Higuchi K. Hereditary pancreatitis model WBN/Kob rat strain has a unique haplotype in the Pdwk1 region on choromosome 7. Exp Anim 58(4):409-413.

Umezawa M, Higuchi K, Mori M, Matsushita T, Hosokawa M. Effect of dietary unsaturated fatty acids on senile amyloidosis in senecsence-accelerated mice. J Gerontol A Biol Sci Med Sci 64(6):646-652. Epub 2009 Apr 17.

Yoshida T, Zhang P, Fu X, Higuchi K, Ikeda S. Slaughtered aged cattle might become one dietary source exhibiting amyloid enhancing factor activity. Amyloid 16(1):25-31.

樋口京一。アミロイド−シスの伝播 〜チータのアミロイドーシスを例に〜。『血液フロンティア』 vol.19(9) p.1397-1402、医薬ジャーナル社

樋口京一。アミロイド。『新老年学(第3版)』p.??-??

医学のあゆみ『アミロイドーシス UPDATE』vol 225(No 5) 医歯薬出版
１。樋口京一､前田秀一郎。アミロイドーシスのモデル動物。p.423-428
２。樋口京一。アミロイドーシスの伝播 -プリオン病以外のアミロイドーシスは伝播するのか？ 436-440

＜学会賞受賞＞ Zhang B. Characterization of the cheetah serum amyloid A1 (SAA1) gene: critical role and functional polymorphism of a cis-acting element. J Heredity 99:355-363 (20008).（米国遺伝学協会 ステファンＪオブライエン賞 '09 (学生筆頭著者に対する最優秀論文賞）2009.6.29)

（2008年）

Zhang B, Une Y, Fu X, Yan J, Ge F, Yao J, Sawashita J, M Mori, Tomozawa H, Kametani F, Higuchi K. Fecal translation of AA amyloidosis in the cheetah contributions to high incidence of disease. Proc Nat Acad Sci USA 105:7263-7268. Epub 2008 May 12.

Zhang B, Une Y, Ge F, Fu X, Qian J, Zhang P, Sawashita J, Higuchi K, Mori M. Characterization of the cheetah serum amyloid A1 (SAA1) gene: critical role and functional polymorphism of a cis-acting element. J Heredity 99:355-363. Epub 2008 Mar 28.

"Biophysical Inquiry into Protein Aggregation and Amyloid Diseases " P.L. San Biagio and D. Bulone eds. Research SignPost , India
Higuchi K, Fu X, B Zhang, Sawashita J, Mori M. Genetics and transmission of mouse systemic amyloidosis. 253-267.

Zhang G, Zhang B, Fu X, Tomozawa H, Matsumoto K, Higuchi K, Mori M. Senescence-Accelerated Mouse (SAM) strains have a spontaneous mutation in the Abcb1a gene. Exp Anim 57(4):413-417.

樋口京一､池田修一。全身性アミロイドーシスの伝播。『プリオン病と遅発性ウイルス感染症』（水沢英洋 編）p.??-??、金原出版

樋口京一。アミロイドモデル動物。『老化・老年病研究のための動物実験ガイド』（日本基礎老化学会 編）p.95-100、アドスリー(丸善)

樋口京一。分子シャペロンとアミロイドーシス。分子細胞治療 7(4): 318-323.

樋口京一。アミロイドーシス。蛋白質 核酸 酵素 53(8): 907.

樋口京一、張 倍茹、宇根有美、亀谷富由樹、澤下仁子、森 政之。チーターのアミロイドーシスはプリオンのように伝播するか？。Dementia Japan 22(2): 207-214.

樋口京一。チーターのアミロイドーシス：アミロイドーシスはプリオンのように伝播するか？ 信州医誌

＜学会賞受賞＞ 森 政之、澤下仁子、樋口京一。「Functional Polymorphisms of the LSS and Fdft1 genes in laboratory rats.」Exp Anim 56(2): 93-101 (2007).（日本実験動物学会 2007年度最優秀論文賞　2008.5.15)　

（2007年）

Yan J, Fu X, Ge F, Zhang B, Yao J, Zhang H, Qian J, Tomozawa H, Naiki H, Sawashita J, Mori M, Higuchi K. Cross-seeding and cross-competition in mouse apolipoprotein A-II amyloid fibrils (AApoAII) and protein A amyloid fibrils (AA). Am J Pathol 171(1): 172-180. Epub 2007 May 18.

Ge F, Yao J, Fu X, Guo Z, Yan J, Zhang B, Zhang H, Tomozawa H, Miyazaki J, Sawashita J, Mori M, Higuchi K. Amyloidosis in transgenic mice expressing murine amyloidgenic apolipoprotein A-II (Apoa2C). Lab Invest 87(7): 633-643. Epub 2007 Apr 30.

Mori M, Sawashita J, Higuchi K. Functional Polymorphisms of the LSS and Fdft1 genes in laboratory rats. Exp Anim 56(2): 93-101.

Otsuki B, Matsumura T, Shimizu M, Mori M, Okudaira S, Nakanishi R, Higuchi K, Hosokawa M, Tsuboyama T, Nakamura T.Quantitative Trait Locus that Determines the Cross-sectional Shape of the Femur in SAMP6 and SAMP2 mice. J Bone Miner Res 22(5): 675-685.

Chiba T, Yao J, Higami Y, Shimokawa I, Hosokawa M, Higuchi K. Identification of differentially expressed genes in senescence-accelerated mouse testes by suppression subtractive hybridization analysis. Mamm Genome 18(2): 105-112. Epub 2007 Feb 28.

樋口京一。アミロイドーシスの伝播。細胞工学 26: 177-188

"XIth International Symposium on Amyloidosis" Skinner M, Berk JL, Connors LH, Seldin DC eds. CRC Press, USA
1. Fu X, Korenaga T, Yan J, Ge F, Zhang B, Qian J, Naiki H, Sawashita J, Mori M, Higuchi K. Mouse senile amyloidosis: possible horizontal transmission in the mouse room. 10-12
2. Higuchi K, Ge F, Fu X, Yao J, Zhang B, Zhang H, Qian J, Sawashita J, Mori M. Amyloidosis in the transgenic mice of mouse amyloidgenic apolipoprotein A-II (Apoa2C). 143-145

＜学会賞受賞＞ 張 国紅、森 政之、張 倍茹、友沢 寛、松本清司、樋口京一。「SAM系マウスは多剤耐性Abcb1a遺伝子に機能喪失突然変異をもつ」（第24回日本疾患モデル学会総会　優秀発表賞　2007.9.1)　

（2006年）

Mori M, Higuchi K, Matsumoto K. A Third locus for eosinophilia on chromosom e1 of the MES rats. Exp Anim 55(5): 497-500.

Nakanishi R, Shimizu M, Mori M, Akiyama H, Othuki B, Okudaira S, Hashimoto M, Higuchi K, Tsuboyama T, Nakamura T. Secreted Frizzled-Related Protein 4 as a negative regulator of bone formation and a candidate gene affecting peak bone mineral density in mice. J Bone Mineral Res 21(11): 1713-1721.

Zhang H, Sawashita J, Fu X, Korenaga T, Yan J, Mori M, Higuchi K. Transmissibility of mouse AApoAII amyloid fibrils: inactivation by physical and chemical methods. FASEB J 20(7): 1012-1014. Epub 2006 Mar 20.

Korenaga T, Yan J, Sawashita J, Matsusita T, Naiki H, Hosokawa M, Mori M, Higuchi K, Fu X. Transmission of amyloidosis in offspring of mice with AApoAII amyloidosis. Am J Pathol 168(3): 898-906.

Mori M, Li G, Abe I, Nakayama J, Guo Z, Sawashita J, Ugawa T, Nishizono, Serikawa T, Higuchi K, Shumiya S. Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. J Clin Invest 116(2): 395-404. Epub 2006 Jan 26.

Yan J, Fujii K, Yao J, Kishida H, Hosoe K, Sawashita J, Takeda T, Mori M, Higuchi K. Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice. Exp Gerontol 41(2): 130-140. Epub 2006 Jan 4.

（2005年）

Tojo K, Tokuda T, Hoshii Y, Fu X, Higuchi K, Matsui T,Kametani F, Ikeda S. Unexpectedly high incidence of visceral AA-amyloidosis in slaughtered cattle in Japan. Amyloid 12(2): 103-108.

Li G, Guo Z, Higuchi K, Kawakubo M, Matsumoto K, Mori M. A locus for eosinophilia in the MES rat is on Chromosome 19. Mamm Genome 16(7): 516-523.

"Amyloid and Amyloidosis" Grateau G, Kyle RA, Skinner M eds. CRC Press, USA 551 pages
1. Sawashita J, Zhang H, Fu X, Korenaga T, Mori M, Higuchi K. Transmission of Mouse AApoAII Amyloidosis by the Amyloid Fibrils; Inhibitory Effects on Transmission by the Denaturation / Degradation of Amyloid Fibrils. 457-459
2. Korenaga T, Fu X, Mori M, Sawashita J, Naiki H, Matsushita T, Higuchi K. Transmission of Mouse AApoAII Amyloidosis from Mother to Pups. 460-462

（2004年）

Fu X, Korenaga T, Xing Y, Fu L, Guo Z, Matsushita T, Hosokawa M, Naiki H, Baba S, Kawata Y, Ikeda S, Ishihara T, Mori M, Higuchi K. Induction of AApoAII amyloidosis by various heterogeneous amyloid fibrils. FEBS Lett 563: 179-184

Korenaga T, Fu X, Xing Y, Matsusita T, Kuramoto K, Syumiya S, Hasegawa K, Naiki H, Ueno M, Ishihara T, Hosokawa M, Mori M, Higuchi K. Tissue Distribution, Biochemical Properties and Transmission of Mouse Type A AApoAII Amyloid Fibrils. Am J Pathol 164: 1597-1606.

Yao J, Chiba T, Sakai J, Hirose K, Yamamoto M, Hada A, Kuramoto K, Higuchi K, Mori M. Mouse testis transcriptome revealed using serila analysis of gene expression. Mamm Genome 15: 433-451.

Yazaki M, Fushimi T, Tokuda T, Kametani F, Yamamoto K, Matsuda M, Shimojo H, Hoshii Y, Higuchi K, Ikeda S. A patient with severe renal amyloidosis associated with an immunoglobulin gamma-heavy chain fragment. Am J Kidney Dis. 43: e23-28.

Wei L, Kawano H, Fu X, Cui D, Ito S, Yamamura K, Ishihara T, Tokuda T, Higuchi K, Maeda S. Deposition of transthyretin amyloid is not accelerated by the same amyloid in vivo. Amyloid 11(2):113-120.

Tojo K, Tokuda T, Yazaki M, Oide T, Nakamura A, Mitsuhashi S, Kaneko K, Maruyama K, Kametani F, Higuchi K, Ikeda SI. Paraneoplastic Sensorimotor Neuropathy and Encephalopathy Associated with Anti-alpha-Enolase Antibody in a Case of Gastric Adenocarcinoma. Eur Neurol. 51: 231-233.

樋口京一、森　政之。SAM(老化促進モデルマウス)。　『モデル動物の作成と維持』（森脇和郎、山村研一、米川博通編）エル・アイ・シー（東京）

樋口京一。アミロイドーシスの伝播機構。『細胞における蛋白質の一生』（小椋　光、遠藤斗志也、森　正敬、吉田賢右編）　pp1101-1104, 蛋白質核酸酵素増刊　共立出版

樋口京一。アミロイドーシスと老化、日本アフェレシス学会雑誌 23: 143-150

"The Senescence-Accelerated Mouse (SAM): an animal model of senescence" Nomura Y, Takeda T, Okuma Y eds. Elsevier BV Amsterdam, The Netherlands 448 pages
1. Higuchi K, Xing Y, Fu X, Korenaga T, Guo Z, Nakamura A, Mori M. Mouse senile amyloidosis in the SAM model. 35-40
2. Sawashita J, Higuchi K, Nakai K, Murase S, Hosokawa M, Miyamoto M, Akiguchi I, Yakeda T. Homepage of the Council for SAM Research (http://samrc.md/shinshu-u.ac.jp) 175-178
3. Mori M, Higuchi K. Genetic monitoring system for SAM strains utilizing DNA markers. 187-190
4. Yanagidaira Y, Higuchi K. Physiological characteristics in SAMP1 and SAMP2 mice. 191-196
5. Toichi E, Matsushita T, Higuchi K, Hosokawa T, Hosokawa M, Hosono M. Relationship between immune activity, senile amyloidosis and life span of hybrids of SAMP1 and B1-.BR mice. 357-361
6. Fu X, Korenaga T, xing Y, Fu L, Guo Z, Matsushita T, Hosokawa M, Naiki H, Mori M, Higuchi K. Induction of AApoAII and AA amyloidosis by the injections of various amyloid fibrils. 383-386
7. Umezawa M, Okumura H, Hosokawa M, Takeda T, Higuchi K. Effects of dietary fats on senile amyloidosis in SAMP1 mice. 427-431

（2003年）

Mori M, Yamasaki K, Nakanishi S, Kitada K, Higuchi K, Namiki C, Hamada S, Serikawa T. A New Beige Mutant Rat ACI/N-Lystbg-Kyo. Exp Anim. 52: 31-36.

Umezawa M, Tatematsu K, Korenaga T, Fu X, Matushita T, Okuyama H, Hosokawa M, Takeda T, Higuchi K. Dietary fat modulation of apoA-II metabolism and prevention of senile amyloidosis in the senescence- accelerated mouse. J Lipid Res. 44: 762-769.

Yanagidaira Y, Higuchi K, Nose H. Diurnal rhythm disorder of behavioral activity in SAMP1 mice is partially normalized by spontaneous wheel running. Physol. Behav. 80, 195-201.

Kitagawa K, Wang J, Mastushita T. Kogishi K, Hosokawa M, Fu X, Guo Z, Mori M, Higuchi K. Polymorphisms of mouse apolipoprotein A-II: seven alleles found among 41 inbred strains of mice. Amyloid. 10: 207-214.

Guo Z, Mori M, Fu X, Yao J, Xing Y, Korenaga T, Li G, Matsushita T, Hosokawa M, Higuchi K. Amyloidosis modifier genes in less amyloidogenic A/J mouse strain. Lab Invest 83:1605-1613.

Guo Z, Higuchi K, Mori M. Spontaneous hypomorphic mutations in antioxidant enzymes of mice. Free Radic Biol Med. 35, 1645-1652

Masui N, Nishikawa T, Takagi Y, Mori M, Suzuki T, Sato K. The Rat Lysosomal Trafficking Regulator (Lyst) Gene is Mapped on the Telomeric Region of Chromosome 17. Exp Anim. 52: 89-91.

Anunciado RV, Nishimura M, Mori M, Ishikawa A, Tanaka S, Horio F, Ohno T, Namikawa T. Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J x A/J)F2 mice. Exp Anim. 52: 37-42.

森　政之、芹川忠夫。遺伝学解析のモデル動物・マウス。『これだけは知っておきたい、遺伝子医学の基礎知識』（有井滋樹、武田俊一、平井久丸、三木哲郎編）pp154-158, メディカル　ドゥ（大阪）

樋口京一、森　政之。『分子生物学・免疫学キーワード辞典（第2版）』医学書院

森　政之。他因子遺伝疾患モデルとしての白内障ラットの解析。信州医学会雑誌 51: 105-106.

獲得研究費
特定領域（ゲノム）：骨粗鬆症モデルマウス(SAMP6)を用いた骨量決定遺伝子群の同定　（樋口）
特定領域（蛋白質の一生）：病的構造タンパク質（アミロイド線維）の伝播及び形成機構の解析　（樋口）
特定領域（感染・免疫）：アミロイド線維による伝播／感染機構と宿主応答の解析　（樋口）
特定領域（ゲノム）：新たに発見された活性型L1トランスポゾンを利用した突然変異マウス昨出と遺伝子同定（森）
若手研究：アミロイド線維の伝播経路と発症促進作用に関する研究（澤下）
厚生労働省科学研究補助金：アミロイドーシスに関する研究班（樋口）
CREST: 「アミロイドーシス発症の分子機構解明」(分担）

（2002年）

Xing Y, Nakamura A, Korenaga T, Guo Z, Yao J, Fu X, Matsushita T, Kogishi K, Hosokawa M, Kametani F, Mori M, Higuchi K. Induction of protein conformational change in mouse senile amyloidosis. J Biol Chem. 277: 33164-33169.

Xing Y, Higuchi K. Amyloid Fibril Proteins. Mech Ageing Dev. 123: 1625-1636.

Shimizu M, Higuchi K, Kasai S, Tsuboyama T, Matsushita M, Matsumura T, Okudaira S, Mori M, Koizumi A, Nakamura T, Hosokawa M. A congenic mouse and candidate gene at the Chr 13 locus regulating bone density. Mamm. Genom. 13: 335-340 2002

Kaneko K, Nakamura A, Yoshida K, Kametani F, Higuchi K, Ikeda S. Glial fibrillary acidic protein is greatly modified by oxidative stress in aceruloplasminemia brain. Free Radic Res 36: 303-306

Ohta A, Akiguchi I, Seriu N, Ohnishi K, Yagi H, Higuchi K, Hosokawa M. Deterioration in learning and memory of inferential tasks for evaluation of transitivity and symmetry in aged SAMP8 mice. Hippocampus 12:803-810.

Suzuki T, Tozuka M, Kazuyoshi Y, Sugano M, Nakabayashi T, Okumura N, Hidaka H, Katsuyama T, Higuchi K. Predominant apolipoprotein J exists as lipid-poor mixtures in cerebrospinal fluid. Ann Clin Lab Sci. 32: 369-76.

森　政之。老化モデル。『老年医学テキスト（改訂版）』（動物社団法人日本老年医学会編）pp. 17-19, メジカルビュー（東京）

森　政之。Chediak-Higashi症候群とベージュミュータント動物。　『免疫疾患―state of arts ver. 2』（別冊・医学のあゆみ、今西二郎・淀井淳司・湊長博編）pp. 303-306. 医歯薬出版 (東京)

森　政之、樋口京一。老化疾患モデル - マウス。　現代医療 34: 37-42.

森　政之。遺伝性銅代謝異常症のモデルマウス・ラット。　臨床検査 45: 754-757.

森　政之、樋口京一。老化疾患モデルマウス Molecular Medicine 39:

（2001年）

Xing Y, Nakamura A, Chiba T, Kogishi K, Matsushita T, Li F, Guo Z, Hosokawa M, Mori M, Higuchi K. (2001) Transmission of mouse senile amyloidosis. Lab Invest 81: 493-499 .

Mori M, Toyokuni S, Kondo S, Kasai H, Naiki H, Toichi H, Hosokawa M, Higuchi K. (2001) Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence. Free Radic Biol Med 30 : 1130-1136.

Fu L, Matsuyama I, Chiba T, Xing Y, Korenaga T, Guo Z, Nakayama J, Mori M, Higuchi K. (2001) Extra-hepatic expression of apolipoprotein A-II in mouse tissues: Possible contribution to mouse senile amyloidosis. J Histochem Cytochem 49 : 739-748.

Mizutani J, Chiba T, Tanaka M, Higuchi K, Mori M. (2001) Unique mutations in mitochondrial DNA of Senescence-Accelerated Mouse (SAM) strains. J Hered 92: 352-355.

Shimizu M, Higuchi K, Kasai S, Tsuboyama T, Matsushita M, Mori M, Shimizu Y, Nakamura T, Hosokawa M. (2001) Chromosome 13 locus, pbd2, regulates bone density in mice. J Bone Mineral Res 16 : 1972-1982.

Ohta A, Higuchi K, Seriu N, Ohnishi K, Yagi H, Higuchi K, Hosokawa M. (2001) Deterioration in learning and memory of fear conditioning in response to context in aged SAMP8 mice. Neurobiol Aging 22: 479-484.

Tsuji A, Nishikawa T, Mori M, Suda K, Nishimori I, Nishimura M. (2001) Quantitative trait locus analysis for chronic pancreatitis and diabetesmellitus in the WBN/Kob rat. Genomics 74 : 365-369

Anunciado RVP, Nishimura M, Mori M., Ishikawa A, Tanaka S, Horio F, Ohno T, Namikawa T. (2001) Quantitative trait loci for body weight in the intercross between SM/J and A/J mice. Exp Anim. 50: 319-324.

樋口京一。(2001) アミロイド線維蛋白質。『分子シャペロンによる細胞機能制御』（永田和宏、森正敬、吉田賢右編）pp164-174,　シェフリンガーフェアラーク東京（東京）

樋口京一、森　政之。(2001) 老化促進マウス（SAM）の解析。BIO Clinica. 16: 57-61.

森　政之、樋口京一。(2001) マウスを用いた老化・寿命の分子遺伝学的研究　基礎老化研究 25: 77-82.

樋口京一、梅澤眞樹子。(2001) SAMPとリポ蛋白質Geriatric Medicine. 39: 1399-1404.

（2000年）

Wang J, Matsushita T, Kogishi K, Xia C, Ohta A, Chiba T, Nakamura A, Kondo H, Mori M, Hosokawa M, Higuchi K. (2000) Wild type ApoA-II gene does not rescue Senescence-accelerated mouse (SAMP1) from short life span and accelerated mortality. J Gerontol B Biol Sci 55A; B432-439

Guo Z, Toichi E, Hosono M, Hosokawa T, Hosokawa M, Higuchi K, Mori M (2000) Genetic analysis of lifespan in hybrid progeny derived from the SAMP1 mouse strain with accelerated senescence. Mech Ageing Dev 118; 35-44

Nishikawa T, Takahashi JA, Matsushita T, Ohnishi K, Higuchi K, Hashimoto N, Hosokawa M.(2000) Tubular aggregates in the skeletal muscle of the senescence-accelerated mouse; SAM. Mech Ageing Dev 114: 89-99

Umezawa M, Takeda T, Kogishi K, Higuchi K, Matushita T, Wang J, Chiba T, Hosokawa M. (2000) Serum lipid concentrations and mean life span are modulated by dietary polyunsaturated fatty acids in the Senescence-accelerated mouse. J Nutr 130: 221-227.

Anunciado RVP., Ohno T., Mori M., Ishikawa A., Tanaka S., Horio F., Nishimura M., Namikawa T. (2000) Distribution of body weight, blood insulin andlipid levels in the SMXA recombinant inbred strains and the QTL analysis. Exp Anim 49: 217-224

Yazaki M, Tokuda T, Nakamura A, Higashikata T, Koyama J, Higuchi K, Harihara Y, Baba S, Kametani F, Ikeda S. (2000) Cardiac amyloid in patients with familial amyloid polyneuropathy consists of abundant wild-type transthyretin. Biochem Biophys Res Commun. , ;274: 702-706.

Sakata C, Tanaka H, Takemura S, Hirohashi K, Minamiyama Y, Nakamura A, Inoue M, Kinoshita H. (2000) Post-ischemic intraportal adenosine administration protects against reperfusion injury of canine liver. J Hepatobiliary Pancreat Surg 7; 78-85

Nakamura A, Park A, Nagata K, Sato EF, Kashiba M, Tamura T, Inoue M. (2000). Oxidative cellular damage associated with transformation of helicobacter pylori from a bacillary to a coccoid form. Free Radic Biol Med. 28: 1611-1618.

Kikuchi T, Ichikawa M, Arai J, Tateiwa H, Fu L, Higuchi K, Yoshimura N (2000). Molecular cloning and characterization of a new neuron-specific homologue of rat polypyrimidine tract binding protein. J Biochem (Tokyo), 128: 811-821.

Shoji M, Matsushita T, Higuchi K, Honda Y, Hosokawa M: Related Articles Senile ocular amyloidosis in SAM and BALB/c strains of mice. Mech Ageing Dev. 2000 120: 87-94.

中村明宏、朴雅美、長田久美子、佐藤英介、田村俊秀、井上正康：H.pyloriの活性酸素代謝とバイオモジュレーション。フリーラジカルの臨床　14: 8-11, 1999

中村明宏、樋口京一：老化モデル動物の性差。Geriatric Medicine 2000 (印刷中）

（1999年）

Chiba T,Kogishi K,Wang J,Xia C,Matsushita T,Miyazaki J,Saito I,Hosokawa M,Higuchi K:Mouse senile amyloid deposition is suppressed by adenovirus-mediated overexpression of amyloid-resistant apolipoprotein A-｢. Am J Pathol 155:1319-1326,1999.

Higuchi K,Hosokawa M,Takeda T:The Senescence-Accelerated Mouse. Methods Enzymol 309:674-686,1999.

Xia C, Higuchi K,Shimizu M,Matsushita T,Kogishi K,Wang J,Chiba T,Festing MF,Hosokawa M:Genetic typing of the senescence-accelerated mouse (SAM) strains with microsatellite markers.Mamm Genome 10:235-238,1999.

Shimizu M,Higuchi K,Bennett B,Xia C,Tsuboyama T,Kasai S,Chiba T,Fujisawa H,Kogishi K,Kitado K,Kimoto M,Matsusita M,Okumura H,Serikawa T,Nakanura T,Johnson TE, Hosokawa M:Identification of peak bone mass QTL in a spontaneously osteoprptic mouse strain. Mamm Genome 10:81-87,1999.

Takeda M,Tsuboyama T,Kasai R,Shimizu M,Nakamura T,Higuchi K,Hosokawa M:Ezpression of c-fos gene induced by parathyroid hormone in bones of SAMP6 mice, a murine model for senile osteoporosis. Mech Ageing Devel 108:87-97,1999.

Fujisawa H,Nishizawa T,Zhu BH,Nishimura Y,Shimizu M,Kimoto M,Higuchi K,HosokawaM:Aminoguanidine supplementation delays the onset of senescence in vitro in dermal fibroblast-like cells from Senescence-accelerated mice.J Gerontol 54:B276-B282, 1999.

Mori M,Nishikawa T,Higuchi K,Nishimura :Deletion in the beige rat owing to recombination between LINE1s . Mamm Genome 10:692-695,1999.

Nakamura A,Yasuda K,Nakamoto H,Adachi H,Akurai Y,Ishii N,Goto:A vitellogenin-6 is a major carbonylated protein in aged nematoda, C-elegans. Biophys Res Commun 264:580-583,1999.

Sakata C,Tanaka H,Takemura SMiyaa Y,Nakamura A,Katsuragi K,Huang H,Kubo S,Kinoshita H:Effect of intraportal infusion of adenosine on hepatic blood flow and injury after ischemia and reperfusion of canine liver.Transplant 31:1027-1028,1999.

Chiba T, Kogishi K, Wang J, Xia C, Matsushita T,Hosokawa M, MIyazaki J, Saito I Sasai Y, HIiguchi K, AApoAII amyloid deposition is suppress by adenovirus-mediated overexpression of type B apolipoprotein A-｢ gene in the mice. Kyle RA,Gertz.eds pp 56-58,Parthenon Publishing,New York,1999.

Higuchi K, Kogishi, Wang J, Chen X, Chiba T, Matsushita T,Hoshi H, Kawano T,Ishihara T, Hosokawa M: Fibrization in mouse senile amylidosis is fibril conformation dependent. Kyle RA,Gertz eds Amiloid and Amyloidosis1998.
pp 47-49, Parthenon Publishing., New York,1999.

樋口京一、細川昌則：SAMマウス、日本遺伝子学治療学会編：遺伝子治療開発研究ハンドブック　pp997-999、エヌ・ティ・エス、東京、1999.

中村明宏：高地における活性酸素代謝特性、井上正康編：活性酸素と運動.pp 166-171,共立出版、東京、1999．

中村明宏、Parl Ah-Mee,　長田久美子、田村俊秀、井上正康：Helicobactor pylori　の活性酸素代謝とバイオモジュレーション、フリーラジカルの臨床14:8−11,1999.　

Goto S, Nakamura A, Radak Z, Nakamoto H, Takahashi R, Yasuda K, Sakurai Y, Ishii N:Carbonylated proteins in aging and exercise: immunoblot approrches. Mech Aging Dav 107:245-253,1999.

細川昌則、坪山直生、樋口京一、松下陸、中村孝志：老年性骨粗鬆症（老化促進） Molecular Medicine 36: 46-49,1999.