＜主な業績＞

1. Ohhashi T, Kawai Y: Proposed new lymphology combined with lymphatic physiology, innate immunology, and oncology (Review). J Physiol Sci, in press, 2014
2. Ohhashi T, Kawai Y: New lymphology combined with lymphatic physiology, innate immunology, and oncology (Commentary). J Blood Lymph, in press, 2014
3. Kawai Y, Kaidoh M, Yokoyama Y, Ohhashi T: Pivotal Roles of Lymphatic Endothelial Cell Layers in the Permeability to Hydrophilic Substances through Collecting Lymph Vessel Walls: Effects of Inflammatory Cytokines. Lymphat Res Biol. 12(3): 124-135, 2014
4. Kawai Y, Kaidoh M, Yokoyama Y, Ohhashi T: Cell surface F1/FO ATP synthase contributes to interstitial flow-mediated development of the acidic microenvironment in tumor tissues. Am J Physiol Cell Physiol. 305(11): C1139-1150, 2013
5. Y. Kawai, M. Kaidoh, Y. Yokoyama, T. Ohhashi: Pivotal roles of shear stress in the microenvironmental changes that occur within sentinel lymph nodes. Cancer Sci., 103：1245-1252, 2012
6. Y. Kawai, K. Yoshida, M. Kaidoh, Y. Yokoyama, T. Ohhashi: Shear stress-mediated F1/FO ATP synthase-dependent CO2 gas excretion from human pulmonary arteriolar endothelial cells. J. Cell Physiol., 227: 2059-2068, 2012
7. Y. Kawai, K. Ajima, T. Nagai, M. Kaidoh, T. Ohhashi: Real-time imaging of the lymphatic channels and sentinel lymph nodes of the stomach using contrast-enhanced ultrasonography with Sonazoid in a porcine model. Cancer Sci., 102: 2073-2081, 2011
8. D. Maejima, Y. Kawai, K. Ajima, T. Ohhashi: Platelet-derived growth factor (PDGF)-BB produces NO-mediated relaxation and PDGF receptor β-dependent tonic contraction in murine iliac lymph vessels. Microcirculation., 18: 474-486, 2011
9. Y. Kawai, Y. Yokoyama, M. Kaidoh, T. Ohhashi: Shear stress-induced ATP-mediated endothelial constitutive nitric oxide synthase expression in human lymphatic endothelial cells. Am. J. Physiol. Cell Physiol., 298: C647-C655, 2010
10. Y. Kawai, T. Ohhashi: Topics of physiological and pathophysiological functions of lymphatics. Curr. Mol. Med., 9: 942-953, 2009
11. H. Song, J. Suehiro, Y. Kanki, Y. Kawai, K. Inoue, H. Daida, K. Yano, T. Ohhashi, P. Oettgen, WC. Aird, T. Kodama, T. Minami: Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J. Biol. Chem., 284: 29109-29124, 2009
12. Y. Kawai, M. Kaidoh, Y. Yokoyama, K. Sano, T. Ohhashi: Chemokine CCL2 facilitates ICAM-1-mediated interactions of cancer cells and lymphatic endothelial cells in sentinel lymph nodes. Cancer Sci., 100: 419-428, 2009
13. F. Ikomi, Y. Kawai, J. Nakayama, N. Ogiwara, K. Sasaki, R. Mizuno, T. Ohhashi: Critical roles of VEGF-C-VEGF receptor 3 in reconnection of the collecting lymph vessels in mice. Microcirculation., 15: 591-603, 2008
14. S. Suzuki, R. Mizuno, F. Ikomi, T. Ohhashi: Head-down tilt posture elicits transient lymphocyte mobilization from the iliac, but not mesenteric, lymph nodes of rats. J. Appl. Physiol., 105: 1595-1601, 2008
15. Y. Kawai, M. Kaidoh, T. Ohhashi: MDA-MB-231 produces ATP-mediated ICAM-1-dependent facilitation of the attachment of carcinoma cells to human lymphatic endothelial cells. Am. J. Physiol. Cell Physiol., 295: C1123-1132, 2008
16. X. Li, R. Mizuno, N. Ono, T. Ohhashi: Glucose and glucose transporters regulate lymphatic pump activity through activation of the mitochondrial ATP-sensitive K+ channel. J. Physiol. Sci., 58: 249-261, 2008
17. Y. Kawai, K. Hosaka, M. Kaidoh, T. Minami, T. Kodama, T. Ohhashi: Heterogeneity in immunohistochemical, genomic, and biological properties of human lymphatic endothelial cells between initial and collecting lymph vessels. Lymphat. Res. Biol., 6: 15-27, 2008
18. T. Nagai, F. Ikomi, S. Suzuki, T. Ohhashi: In situ lymph dynamic characterization through lymph nodes in rabbit hind leg: special reference to nodal inflammation. J. Physiol. Sci., 58: 123-132, 2008
19. H. Koyama, N. Kobayashi, M. Harada, M. Takeoka, Y. Kawai, K. Sano, M. Fujimori, J. Amano, T. Ohhashi, R. Kannagi, K. Kimata, S. Taniguchi, N. Itano: Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis: pivotal role of a hyaluronan-rich tumor microenvironment. Am. J. Pathol., 172: 179-193, 2008
20. Y. Kawai, T. Minami, M. Fujimori, K. Hosaka, R. Mizuno, F. Ikomi, T. Kodama, T. Ohhashi: Characterization and microarray analysis of genes in human lymphatic endothelial cells from patients with breast cancer. Lymphat. Res. Biol., 5: 115-126, 2007
21. T. Omachi, Y. Kawai, R. Mizuno, T. Nomiyama, S. Miyagawa, T. Ohhashi, J. Nakayama: Immunohistochemical demonstration of proliferating lymphatic vessels in colorectal carcinoma and its clinicopathological significance. Cancer Lett., 246: 167-172, 2007
22. F. Ikomi, Y. Yokoyama, N. Ogiwara, K. Sasaki, R. Mizuno, T. Ohhashi: Recanalization of the collecting lymphatics in rabbit hind leg. Microcirculation., 13: 365-376, 2006
23. R. Mizuno, N. Ono, F. Ikomi, T. Ohhashi: A new preparation for visualizing lymphatic flow pathway in isolated rat lymph nodes. Lymphatic Res. Biol., 3: 127-136, 2005
24. N. Ono, R. Mizuno, T. Ohhashi: Effective permeability of hydrophilic substances through walls of lymph vessels: roles of endothelial barrier. Am. J. Physiol., 289: H1676-H1682, 2005
25. T. Ohhashi, R. Mizuno, F. Ikomi, Y. Kawai: Current topics of physiology and pharmacology in the lymphatic system (Review). Pharmacol. Ther., 105: 165-188, 2005
26. N. Tomioka, M. Kobayashi, Y. Ushiyama, T. Ohhashi: Effects of exercise intensity, posture, pressure on the back and ambient temperature on palmar sweating responses due to handgrip exercises in humans. Auton. Neurosci., 118: 125-134, 2005
27. R. Cao, M.A. Bjömdahl, P. Religa, S. Clasper, S. Garvin, D. Galter, B. Meister, F. Ikomi, K. Tritsaris, S. Dissing, T. Ohhashi, D.G. Jackson, Y. Cao: PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. Cancer Cell, 6: 333-345, 2004
28. A. Kousai, R. Mizuno, F. Ikomi, T. Ohhashi: ATP inhibits pump activity of lymph vessels via adenosine A1 receptor-mediated involvement of NO- and ATP-sensitive K+ channels. Am. J. Physiol., 287:H2585-H2597, 2004
29. T. Ohhashi: Lymphodynamic properties governing sentinel lymph node. Annals. Surg. Oncol. 11: 275S-278S, 2004
30. K. Hosaka, R. Mizuno, T. Ohhashi: Rho-Rho kinase pathway is involved in the regulation of myogenic tone and pump activity in isolated lymph vessels. Am. J. Physiol. 284: H2015-H2025, 2003
31. H. Tsunemoto, F. Ikomi, T. Ohhashi: Flow-mediated release of nitric oxide from lymphatic endothelial cells of pressurized canine thoracic duct. Jpn. J. Physiol. 53: 157-163, 2003
32. R. Mizuno, Y.Yokoyama, N. Ono, F. Ikomi, T. Ohhashi: Establishment of rat lymphatic endothelial cell line. Microcirculation 10: 127-131, 2003
33. F. Ikomi, A. Kousai, N. Ono, T. Ohhashi: Electrical stimulation-induced α1- and α2-adrenoceptors-mediated contractions of isolated canine lymph nodes. Auton. Neurosci. 96 : 85-92, 2002
34. K. Nakaya, R. Mizuno, T. Ohhashi: B16-BL6 melanoma cells release inhibitory factor(s) of active pump activity in isolated lymph vessels. Am. J. Physiol., 281: C1812-C1818, 2001
35. R. Mizuno, N. Ono, T. Ohhashi: Parathyroid hormone-related protein- (1-34) inhibits intrinsic pump activity of isolated murine lymph vessels. Am. J. Physiol., 281:H60-H66, 2001
36. F. Arai, R. Mizuno, T. Ohhashi: Effects of VEGF on Ca2+-transient in cultured lymphatic endothelial cells and mechanical activity of isolated lymph vessels. Jpn. J. Physiol., 50: 343-355, 2000
37. Y. Shirasawa, F. Ikomi, T. Ohhashi: Physiological roles of endogenous nitric oxide in lymphatic pump activity of rat mesentery in vivo. Am. J. Physiol., 278: G551-G556, 2000
38. N. Ono, R. Mizuno, H. Nojiri, T. Ohhashi: Development of an experimental appratus for investigating lymphatic pumping activity of murine mesentery in vivo. Jpn. J. Physiol., 50: 25-31, 2000
39. R. Mizuno, N. Ono, T. Ohhashi: Involvement of ATP-sensitive K+ channels in spontaneous activity of isolated lymph microvessels in rats. Am. J. Physiol., 277: H1453-H1456, 1999
40. H. Sakai, F. Ikomi, T. Ohhashi: Effects of endothelin on spontaneous contractions in lymph vessels. Am. J. Physiol., 277: H459-H466, 1999
41. H. Nojiri, T. Ohhashi: Immunolocalization of nitric oxide synthase and VEGF receptors in cultured lymphatic endothelial cells. Microcirculation, 6: 75-78, 1999
42. J.L. Zhang, S. Yokoyama, T. Ohhashi: Inhibitory effects of fluorescein isothiocyanate photoactivation on lymphatic pump activity. Microvasc. Res., 54: 99-107, 1997
43. Y. Fukaya, T. Ohhashi: Acetylcholine- and flow-induced production and release of nitric oxide in arterial and venous endothelial cells. Am. J. Physiol., 270: H99-H106, 1996
44. R. Mizuno, T. Ohhashi: 5-Hydroxytryptamine-induced nitric oxide-dependent relaxation in isolated strips of monkey popliteal lymph nodes. Am. J. Physiol., 268: H2246-H2251, 1995
45. T. Ohhashi, S. Yokoyama. : Nitric oxide and the lymphatic system. (Review) Jpn. J. Physiol. 44: 327-342, 1994
46. H. Miyahara, Y. Kawai, T. Ohhashi: 5-Hydroxytryptamine-2 and -4 receptors located on bovine isolated mesenteric lymphatics. J. Pharmacol. Exp. Ther. 271: 379-385, 1994
47. S. Hashimoto, Y. Kawai, T. Ohhashi: Effects of vasoactive substances on the pig isolated hepatic lymph vessels. J. Pharmacol. Exp. Ther. 269: 482-488, 1994
48. T. Ohhashi: Mechanisms for regulating tone in lymphatic vessels.(Review) Biochem. Pharmacol. 45: 1941-1946, 1993
49. S. Yokoyama, T. Ohhashi: Effects of acetylcholine on spontaneous contractions in isolated bovine mesenteric lymphatics. Am. J. Physiol. 264: H1460-H1464, 1993
50. A. Ohhira, T. Ohhashi: Effects of aortic pressure and vasoactive agents on the vascular resistance of the vasa vasorum in canine isolated thoracic aorta. J. Physiol. (Lond) 453: 233-245, 1992
51. F. Ikomi, Y. Kawai, T. Ohhashi: ß-1 and ß-2 adrenoceptors mediate smooth muscle relaxation in bovine isolated mesenteric lymphatics. J. Pharmacol. Exp. Ther. 259: 365-370, 1991
52. T. Ohhashi, N. Takahashi: Acetylcholine-induced release of endothelium-derived relaxing factor from lymphatic endothelial cells. Am. J. Physiol. 260: H1172-H1178, 1991
53. N. Takahashi, Y. Kawai, T. Ohhashi: Effects of vasoconstrictive and vasodilative agents on lymphatic smooth muscles in isolated canine thoracic ducts. J. Pharmacol. Exp. Ther. 254: 165-170, 1990
54. T. Ohhashi, N. Watanabe, Y. Kawai: Effects of atrial natriuretic peptide on isolated bovine mesenteric lymph vessels. Am. J. Physiol. 259: H42-H47, 1990
55. N. Watanabe, Y. Kawai, T. Ohhashi: Demonstration of both ß1- and ß2-adrenoceptors mediating negative chronotropic effects on spontaneous activity in isolated bovine mesenteric lymphatics. Microvasc. Res. 39: 50-59, 1990
56. N. Watanabe, Y. Kawai, T. Ohhashi: Dual effects of histamine on spontaneous activity in isolated bovine mesenteric lymphatics. Microvasc. Res. 36: 239-249, 1988
57. T. Ohhashi, T. Azuma: Pre- and post-junctional alpha-adrenoceptors at sympathetic neuroeffector junction in bovine mesenteric lymphatics. Microvasc. Res. 31: 31-40, 1986
58. T. Ohhashi, T. Azuma: Variegated effects of prostaglandins on spontaneous activity in bovine mesenteric lymphatics. Microvasc. Res. 27: 71-80, 1984
59. T. Ohhashi, J.A. Olschowka, D.M. Jacobowitz: Vasoactive intestinal peptide inhibitory innervation in bovine mesenteric lymphatics: A histochemical and pharmacological study. Circ. Res. 53: 535-538, 1983
60. T. Azuma, T. Ohhashi, I.C. Roddie: Bradykinin-induced contractions of bovine mesenteric lymphatics. J. Physiol. (Lond) 342: 217-227, 1983
61. T. Ohhashi, T. Azuma, I.C. Roddie: Effect of potassium on adrenergic nerve endings in bovine mesenteric lymphatics. J. auton. Nerv. Syst. 8: 205-211, 1983
62. T. Ohhashi, S. Kobayashi, S. Tsukahara, T. Azuma: Innervation of bovine mesenteric lymphatics: from the histochemical point of view. Microvasc. Res. 24: 377-385, 1982
63. T. Ohhashi, T. Azuma: Effects of potassium on membrane potential and tension development in bovine mesenteric lymphatics. Microvasc. Res. 23: 93-98, 1982
64. T. Ohhashi, I.C. Roddie: Relaxation of bovine mesenteric lymphatics in response to transmural stimulation. Am. J. Physiol. 240: H498-H504, 1981
65. T. Ohhashi, I.C. Roddie: Neurogenic relaxation in bovine mesenteric lymphatics. J. Physiol. (Lond) 312: 55-56, 1980
66. T. Ohhashi, N.G. McHale, I.C. Roddie, K.D. Thornbury: Electrical field stimulation as a method of stimulating nerve or smooth muscle in isolated bovine mesenteric lymphatics. Pfluegers Arch. 388: 221-226, 1980
67. T. Ohhashi, T. Azuma, M. Sakaguchi: Active and passive mechanical characteristics of bovine mesenteric lymphatics. Am. J. Physiol. 239: H88-H95, 1980
68. T. Ohhashi, T. Azuma, M. Sakaguchi: Effects of microvibration on activity of ureteral and portal smooth muscles. Am. J. Physiol. 236: C192-C201, 1979
69. T.Ohhashi, T. Azuma, M. Sakaguchi: Transmembrane potential in bovine lymphatic smooth muscles. Proc. Soc. Exp. Biol. Med. (NY)159: 350-352, 1978
70. T. Ohhashi, Y. Kawai, T. Asuma: The response of lymphatic smooth muscles to vasoactive substances. Pfluegers Arch. 375: 183-188, 1978
71. T. Azuma, T. Ohhashi, M. Sakaguchi: Electrical activity of lymphatic smooth muscles. Proc. Soc. Exp. Biol. Med. 155: 270-273, 1977
72. T. Ohhashi, S. Fukushima, T. Azuma: Vasa vasorum within the media of bovine mesenteric lymphatics. Proc. Soc. Exp. Biol. Med. 154: 582-586, 1977