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教員氏名
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河合 佳子
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所属・職名
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東北医科薬科大学医学部生理学 教授
信州大学医学部メディカル・ヘルスイノベーション講座 特任教授
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研究分野
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循環生理学、病態生理学、呼吸生理学
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学会活動
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日本生理学会（評議員）、日本リンパ学会（幹事・評議員）、
日本脈管学会（評議員）、日本微小循環学会（評議員）、
日本形成外科学会（専門医）、日本人間ドック学会（認定医）、日本癌学会
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研究紹介
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(1)流れ刺激が血管・リンパ管内皮細胞に及ぼす影響について
(2)肺細動脈での流れ刺激による炭酸ガス産生機構について
(3)癌細胞の転移巣形成におけるリンパ節内の微小環境変化について
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＜主な業績＞
- Kawai Y, Kaidoh M, Yokoyama Y, Ohhashi T. Pivotal roles of lymphatic endothelial cell layers in the permeability to hydrophilic substances through collecting lymph vessel walls: Effects of inflammatory cytokines. Lymphat Res Biol, 12:124-135, 2014
- Kawai Y, Kaidoh M, Yokoyama Y, Ohhashi T. Cell surface F1/FO ATP synthase contributes to interstitial flow-mediated development of the acidic microenvironment in tumor tissues. Am J Physiol Cell Physiol 305:C1139-C1150, 2013
- Kawai Y, Kaidoh M, Yokoyama Y, Ohhashi T. Pivotal roles of shear stress in the microenvironmental changes that occur within sentinel lymph nodes. Cancer Sci 103:1245-1252, 2012
- Kawai Y, Yoshida K, Kaidoh M, Yokoyama Y, Ohhashi T. Shear stress-mediated F1/FO ATP synthase-dependent CO2 gas excretion from human pulmonary arteriolar endothelial cells. J Cell Phsyiol 227:2059-2068, 2012
- Kawai Y, Ohhashi T. Current topics of immunohistochemical and biological properties of human lymphatic endothelial cells. Ann Vasc Dis 5:269-274, 2012
- Kawai Y, Ajima K, Nagai T, Kaidoh M, Ohhashi T. Real-time imaging of the lymphatic channels and sentinel lymph nodes of the stomach using contrast-enhanced ultrasonography with Sonazoid in a porcine model. Cancer Sci 102:2073-2081, 2011
- Kawai Y, Yokoyama Y, Kaidoh M, Ohhashi T. Shear stress-induced ATP-mediated endothelial constitutive nitric oxide synthase expression in human lymphatic endothelial cells. Am J Physiol Cell Physiol 298:C647-C655, 2010
- Kawai Y, Kaidoh M, Yokoyama Y, Sano K, Ohhashi T. Chemokine CCL2 facilitates ICAM-1-mediated interactions of cancer cells and lymphatic endothelial cells in sentinel lymph nodes. Cancer Sci 100:419-428, 2009
- Kawai Y, Ohhashi T. Topics of physiological and pathophysiological functions of lymphatics. Curr Mol Med 9:942-953, 2009
- Kawai Y, Kaidoh M, Ohhashi T. MDA-MB-231 produces ATP-mediated ICAM-1-dependent facilitation of the attachment of carcinoma cells to human lymphatic endothelial cells. Am J Physiol Cell Physiol 295:C1123-C1132, 2008
- Kawai Y, Hosaka K, Kaidoh M, Minami T, Kodama T, Ohhashi T. Heterogeneity in immunohistochemical, genomic, and biological properties of human lymphatic endothelial cells between initial and collecting lymph vessels. Lymphat Res Biol 6:15-27, 2008
- Kawai Y, Minami T, Fujimori M, Hosaka K, Mizuno R, Ikomi F, Kodama T, Ohhashi T. Characterization and microarray analysis of genes in human lymphatic endothelial cells from patients with breast cancer. Lymphat Res Biol 5:115-126, 2007