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教員氏名
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久米 努
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所属・職名
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Northwestern University Feinberg School of Medicine Department of Medicine Tenured Professor
信州大学医学部メディカル・ヘルスイノベーション講座 特任教授
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学会活動
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日本リンパ学会(理事)、日本血管生物医学会(評議員)、
日本分子生物学会、日本血栓止血学会、
北米血管生物学会(Councilor)、アメリカ心臓学会、アメリカ発生生物学会、
国際幹細胞学会、アメリカ視覚と眼科学研究協会会議
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＜主な業績＞
- Tan C., Norden P., Yu, W., Liu, T., Ujiie, N., Yan, X., Dyakiv, Y., Aoto, K., Ortega, S., De Plaen I.G., Sampath V., & Kume T. Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia-reperfusion injury. EMBO Reports. Online ahead of print. DOI: 10.15252/embr.202256030
- Norden P., Sabine A., Wang Y., Demir C. S., Liu T., Petrova T. V., & Kume T. Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation. eLife. 9, e53814 (2020)
- Sanchez J., Miyake R., Cheng A., Liu T., Iseki S., & Kume T. Conditional inactivation of Foxc1 and Foxc2 in neural crest cells leads to cardiac abnormalities. Genesis. 58, e23364 (2020)
- Kume T. & Shackour T. Meta-analysis of the likelihood of FOXC1 expression in early- and late-stage tumors. Oncotarget 9, 36625-36630 (2018)
- Kume T. & Shackour T. Meta-analysis of the likelihood of FOXC2 expression in early- and late-stage tumors. Oncotarget 9, 33396-33402 (2018)
- Seo S., Chen L., Liu W., Zhao D., Schultz K. M., Sasman A., Liu T., Zhang H. F., Gage P. J. & Kume T. Foxc1 and Foxc2 in the neural crest are required for ocular anterior segment development. Invest. Ophthalmol. Vis. Sci. 58, 1368-1377 (2017)
- Fatima A., Wang Y., Uchida Y., Norden P., Liu T., Culver A., Dietz W., Culver F., Millay M., Mukouyama Y. & Kume T. Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation. J. Clin. Invest. 126, 2437-2451 (2016)
- Lambers E., Arnone B., Fatima A., Qin G., Wasserstrom J. A. & Kume T. Foxc1 regulates early cardiomyogenesis and functional properties of embryonic stem cell derived cardiomyocytes. Stem Cells 34, 1487-1500 (2016)
- Fatima A., Culver A., Culver F., Liu T., Dietz H. W., Thomson B. R., Hadjantonakis A.-K., Quaggin S. E. & Kume T. Murine Notch1 is required for lymphatic vascular morphogenesis during development. Dev. Dyn. 243, 957–964 (2014)
- Sasman A., Nassano-Miller C., Shim K. S., Koo H. Y., Liu T., Schultz K. M., Millay M., Nanano A., Kang M., Suzuki T. & Kume T. Generation of conditional alleles forFoxc1 and Foxc2 in mice. Genesis 50, 766–774 (2012)
- Seo S., Singh H. P., Lacal P. M., Sasman A., Fatima A., Liu T., Schultz K. M., Losordo D. W., Lehmann O. J. & Kume T. Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc. Natl. Acad. Sci. USA. 109, 2015-2020 (2012)
- Sano H., LeBoeuf J. P., Novitskiy S. V., Seo S., Zaja-Milatovic S., Dikov M. M. & Kume T. The Foxc2 transcription factor regulates tumor angiogenesis. Biochem. Biophys. Res. Commun. 392, 201-206 (2010)
- Hayashi H., Sano H., Seo H. & Kume T. The Foxc2 transcription factor regulates angiogenesis via induction of integrin b3 expression. J. Biol. Chem. 283, 23791-23800 (2008)
- Hayashi H. & Kume T. Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells. PLoS ONE 3, e2401 (2008)
- Hayashi H. & Kume T. Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration. Biochem. Biophys. Res. Commun. 367, 584-589 (2008)
- Seo S. & Kume T. Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Dev. Biol. 296, 421-436 (2006)
- Seo S., Fujita H., Nakano A., Kang M., Duarte A. & Kume T. The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev. Biol. 294, 458-470 (2006)
- Kume T., Deng K. & Hogan B. L. M. Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2. Mol. Cell. Biol. 20, 1419-1425 (2000)
- Kume T., Jiang H., Topczewska J. M. & Hogan B. L. M. The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 15, 2470-2482 (2001)
- Kume T., Deng K.-Y., Winfrey V., Gould D. B., Walter M. A. & Hogan B. L. The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. Cell 93, 985-996 (1998)