＜主な業績＞

1. McConnell MJ, Kostallari E, Ibrahim SH, Iwakiri Y. The evolving role of liver sinusoidal endothelial cells in liver health and disease. Hepatology. 2023 (in press).
2. Kondo, R., Kawaguchi, N., McConnell, M.J., Sonzogni, A., Licini, L., Valle, C., Bonaffini, P.A., Sironi, S., Alessio, M.G., Previtali, G., Seghezzi, M., Zhang, X., Sun, Z., Utsumi, T., Strazzabosco, M., and Iwakiri, Y. Pathological characteristics of liver sinusoidal thrombosis in COVID-19 patients: a series of 43 cases. Hepatology Research. 2022; 51(9); 1000 - 1016.
3. Jeong, J., Tanaka, M. & Iwakiri, Y. Hepatic lymphatic vascular system in health and disease. Journal of Hepatology. 2022; 77(1):206-218.
4. McConnell, M.J., Kawaguchi, N., Kondo, R., Sonzogni, A., Licini, L., Valle, C., Bonaffini, P.A., Sironi, S., Alessio, M.G., Previtali, G., Seghezzi, M., Zhang, X., Lee, A., Pine, A.B., Chun, H.J., Zhang, X., Fernandez-Hernando, C., Qing, H., Wang, A., Price, C., Sun, Z., Utsumi, T., Hwa, J., Strazzabosco, M., and Iwakiri, Y. Liver injury in COVID-19 from IL-6 trans-signaling-induced endotheliopathy. Journal of Hepatology. 2021. 75(3):647-658.
5. Yang, Y, Sangwung, P., Jung, Y., Kondo, R., McConnell, M., Utsumi, T., and Iwakiri, Y. Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcoholic liver disease. Journal of Hepatology. 2021, 75(2):377 – 386.
6. Su, T., Yang, Y., Lai, S., Jeong, J., Jung, Y, McConnell, M., Utsumi, T, and Iwakiri, Y. Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis. Cellular and Molecular Gastroenterology and Hepatology. 2021, 11(4):1139-1161.
7. Hsu SJ, Zhang C, Jeong J, Lee SI, McConnell M, Utsumi T, Iwakiri Y. Enhanced meningeal lymphatic drainage ameliorates neuroinflammation and hepatic encephalopathy in cirrhotic rats. Gastroenterology. 2021, 160(4):1315-1329.
8. Iwakiri Y, Trebicka J. Prtal hypertension in cirrhosis: Pathophysiological mechanisms and therapy. JHEP Rep. 2021,3(4):100316.
9. Saruwatari J, Dong C, Utsumi T, Tanaka M, McConnell M, Iwakiri Y. Integrated analysis of microRNA and mRNA expression profiles in splenomegaly induced by non-cirrhotic portal hypertension in rats. Scientific Reports. 2018, 8:17983.
10. Park JK, Shao M, Kim MY, Baik SK, Cho MY, Utsumi T, Satoh A, Ouyang X, Chung C, Iwakiri Y. An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of kupffer cell polarization. Hepatology. 2017, 65:1720-1734.
11. Iwakiri Y, Nathanson MH. Alcohol and calcium make a potent cocktail. J Physiol. 2017, 595(10):3109-3110.
12. Park JK, Utsumi T, Seo YE, Deng Y, Satoh A, Saltzman WM, Iwakiri Y. Cellular distribution of injected PLGA-nanoparticles in the liver. Nanomedicine: Nanotechnology, Biology, And Medicine 2016, 12:1365-74.
13. Iwakiri Y. The lymphatic system: A new frontier in hepatology. 2016, 64(3):706-707.
14. Tanaka M, Iwakiri Y. The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis. Cellular And Molecular Gastroenterology and Hepatology. 2016, 2:733-749.
15. Iwakiri Y. Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase. Clin Mol Hepatol. 2015, 21(4): 319-325.
16. Iwakiri Y, Kim MY. Nitric oxide in liver diseases. Trends Pharmacol Sci. 2015, 36(8):524-536.
17. Iwakiri Y, Shah V, Rockey DC. Vascular pathobiology in chronic liver disease and cirrhosis-current status and future directions. J Hepatol. 2014, 61(4):912-924.
18. Iwakiri Y. Pathophysiology of portal hypertension. Clin Liver Dis. 2014, 18(2): 281-291.
19. Gao L, Utsumi T, Tashiro K, Liu B, Zhang D, Swenson ES, Iwakiri Y. Reticulon 4B (Nogo-B) facilitates hepatocyte proliferation and liver regeneration in mice. Hepatology. 2013, 57:1992-2003.
20. Tashiro K, Satoh A, Utsumi T, Chung C, Iwakiri Y. Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice. The American Journal Of Pathology. 2013, 182:786-95.