|
Department of Molecular Pharmacology |
| トップ | まえがき | 研究テーマ | 論文 | スタッフ | 学生募集 | アクセス |
|---|
|
Two Mechanistically Distinct Effects of Dihydropyridine Nifedipine on CaV1.2 L-Type Ca2+ Channels Revealed by Timothy Syndrome Mutation. Sheng X, Nakada T, Kobayashi M, Kashihara T, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Aoyama T, Yamada M. Eur. J. Pharmacol. 685: 15-23 Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca2+ channel activity through phosphatases in heart failure. Kashihara T, Nakada T, Shimojo H, Horiuchi-Hirose M, Gomi S, Shibazaki T, Sheng X, Hirose M, Hongo M, Yamada M. Am. J. Physiol. Heart Circ. Physiol. 302: H1645-H1654 Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure. Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubota I, Mende U, Yamada M. Circ. J. 75: 2333-2342 Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes. Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, Ueda H, Yamada M. Am. J. Physiol. Heart Circ. Physiol. 300: H978-H988 Acid-Sensing Ion Channels in Blood Volume Regulation. Yamada M. Circ. J. 75: 781-782 Thrombin activates Ca2+-permeating nonselective cation channels through protein kinase C in human umbilical vein endothelial cells. Tsujino N, Nakada T, Tsubouchi K, Kobayashi M, Kawai Y, Yano S, Matsunaga T, Hirose M, Ohmori S, Ohhashi T, Yamada M. Shinshu Med. J. 59: 13-26 Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria. Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M. Int. J. Cardiol. 146: 37-43 Selective α1A-Adrenoceptor Stimulation Induces Mueller’s Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation. Yano S, Hirose M, Nakada T, Nakayama J, Matsuo K, Yamada M. Curr. Eye Res. 35: 363-369 Mitochondrial ATP-sensitive K+ channels, protectors of the heart. Yamada M. J. Physiol. (Lond.) 582: 283-286 Effects of hormone-sensitive lipase-disruption on cardiac energy metabolism in response to fasting and refeeding. Suzuki J, Ueno M, Uno M, Hirose Y, Zenimaru Y, Takahashi S, Osuga JI, Ishibashi S, Takahashi M, Hirose M, Yamada M, Kraemer FB, Miyamori I. Am. J. Physiol. Endocrinol. Metab. 297: E1115-E1124 Diacylglycerol kinase zeta inhibits G(alpha)q-induced atrial remodeling in transgenic mice. Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M. Heart Rhythm. 6: 78-84 Contribution of L-type Ca2+ channels to early afterdepolarizations induced by IKr and IKs channel suppression in guinea-pig ventricular myocytes. Yamada M, Ohta K, Niwa A, Tsujino N, Nakada T, Hirose M. J. Membr. Biol. 222: 151-166 Mechanisms of preventive effect of nicorandil on ischaemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular wedges. Hirose M, Tsujino N, Nakada T, Yano S, Imamura H, Yamada M. Basic Clin. Pharmacol. Toxicol. 102: 504-514 MCP-1 induces cardioprotection against ischaemia/reperfusion injury: role of reactive oxygen species. Morimoto H, Hirose M, Takahashi M, Kawaguchi M, Ise H, Kolattukudy PE, Yamada M, Ikeda U Cardiovasc. Res. 78: 554-62 Mechanisms of the preventive effect of pilsicainide on atrial fibrillation originating from the pulmonary vein. Hirose M, Ohkubo Y, Takano M, Hamazaki M, Sekido T, Yamada M Circ. J. 71:1805-1814 Calcium mediated-triggered activity is an underlying cellular mechanism of ectopy originating from pulmonary vein in canine. Hirose M, Laurita KR Am. J. Physiol. 292: H1861-H1867 Mechanism of atrial tachyarrhythmia induction in a canine model of autonomic tone fluctuation. Hirose M, Imamura H Basic Res. Cardiol. 102: 52-62 Rotigaptide (ZP123) improves atrial conduction slowing in chronic volume overload-induced dilated atria. Haugan K, Miyamoto T, Takeishi Y, Kubota I, Nakayama J, Shimojo H, and Hirose M Basic Clin. Pharmacol. and Toxicol. 99: 71-79 A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K+ channels. Yamada, M. and Kurachi, Y J. Mol. Cell. Cardiol. 39: 1-6 PtdIns(3,4,5)P3 and Ca2+/calmodulin competitively bind to the RGS domain of RGS4 and reciprocally regulate its action. Ishii M, Fujita S, Yamada M, Hosaka Y, Kurachi Y Biochem. J. 385: 65-73 Mechanism for atrial tachyarrhythmia in chronic volume overload-induced dilated atria. Hirose M, Takeishi Y, Miyamoto T, Kubota I, Laurita KR, Chiba S, J. Cardiovasc. Electrophysiol. 16: 760-769 Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K+ channels: Implication for dimerization of nucleotide-binding domains to induce channel opening. Yamada M, Ishii M, Hibino H, Kurachi Y Mol. Pharmacol. 66: 807-816 The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels. Yamada M, Kurachi Y Mol. Pharmacol. 65: 1198-1207 Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes. Hibino H, Fujita A, Iwai K, Yamada M, Kurachi Y J. Biol. Chem.279: 44065-44073 Comparison of kinetic properties of quinidine and dofetilide block of HERG channels. Tsujimae K, Suzuki S, Yamada M, Kurachi Y Eur. J. Pharmacol. 493: 29-40 Effect of Tertiapin on Different Types of Recombinant Inwardly Rectifying Potassium Channels. Makino Y, Matsushita K, Yamashita S, Matsuzawa Y, Yamada M, Kurachi Y Osaka Med. J. |