信州大学医学部・分子薬理学講座

Department of Molecular Pharmacology
Shinshu University School of Medicine

トップ まえがき 研究テーマ 論文 スタッフ 学生募集 アクセス

2009年

Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M.
Int. J. Cardiol. in press

Diacylglycerol kinase zeta inhibits G(alpha)q-induced atrial remodeling in transgenic mice.
Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M.

Heart Rhythm. 6: 78-84


2008年

Contribution of L-type Ca2+ channels to early afterdepolarizations induced by IKr and IKs channel suppression in guinea-pig ventricular myocytes.
Yamada M, Ohta K, Niwa A, Tsujino N, Nakada T, Hirose M.

J. Membr. Biol. 222: 151-166

Mechanisms of preventive effect of nicorandil on ischaemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular wedges.
Hirose M, Tsujino N, Nakada T, Yano S, Imamura H, Yamada M.

Basic Clin. Pharmacol. Toxicol. 102: 504-514

MCP-1 induces cardioprotection against ischaemia/reperfusion injury: role of reactive oxygen species.
Morimoto H, Hirose M, Takahashi M, Kawaguchi M, Ise H, Kolattukudy PE, Yamada M, Ikeda U

Cardiovasc. Res. 78: 554-62


2007年

Mechanisms of the preventive effect of pilsicainide on atrial fibrillation originating from the pulmonary vein.
Hirose M, Ohkubo Y, Takano M, Hamazaki M, Sekido T, Yamada M
Circ. J. 71:1805-1814

Calcium mediated-triggered activity is an underlying cellular mechanism of ectopy originating from pulmonary vein in canine.
Hirose M, Laurita KR
Am. J. Physiol. 292: H1861-H1867

Mechanism of atrial tachyarrhythmia induction in a canine model of autonomic tone fluctuation.
Hirose M, Imamura H
Basic Res. Cardiol. 102: 52-62


2006年

Rotigaptide (ZP123) improves atrial conduction slowing in chronic volume overload-induced dilated atria.
Haugan K, Miyamoto T, Takeishi Y, Kubota I, Nakayama J, Shimojo H, and Hirose M
Basic Clin. Pharmacol. and Toxicol. 99: 71-79


2005年

A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K+ channels.
Yamada, M. and Kurachi, Y
J. Mol. Cell. Cardiol. 39: 1-6

PtdIns(3,4,5)P3 and Ca2+/calmodulin competitively bind to the RGS domain of RGS4 and reciprocally regulate its action.
Ishii M, Fujita S, Yamada M, Hosaka Y, Kurachi Y
Biochem. J. 385: 65-73

Mechanism for atrial tachyarrhythmia in chronic volume overload-induced dilated atria.
Hirose M, Takeishi Y, Miyamoto T, Kubota I, Laurita KR, Chiba S,
J. Cardiovasc. Electrophysiol. 16: 760-769


2004年

Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K+ channels: Implication for dimerization of nucleotide-binding domains to induce channel opening.
Yamada M, Ishii M, Hibino H, Kurachi Y
Mol. Pharmacol. 66: 807-816

The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels.
Yamada M, Kurachi Y
Mol. Pharmacol. 65: 1198-1207

Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes.
Hibino H, Fujita A, Iwai K, Yamada M, Kurachi Y
J. Biol. Chem.279: 44065-44073

Comparison of kinetic properties of quinidine and dofetilide block of HERG channels.
Tsujimae K, Suzuki S, Yamada M, Kurachi Y
Eur. J. Pharmacol. 493: 29-40

Effect of Tertiapin on Different Types of Recombinant Inwardly Rectifying Potassium Channels.
Makino Y, Matsushita K, Yamashita S, Matsuzawa Y, Yamada M, Kurachi Y
Osaka Med. J.


2003年

Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic beta-cell-type KATP channels.
Chachin M, Yamada M, Fujita A, Matsuoka T, Matsuoka T, Kurachi Y
J. Pharmacol. Exp. Ther. 304(3): 1025-1032

Cellular mechanism of PACAP-induced atrial tachyarrhythmia in isolated arterially perfused canine right atria.
Hirose M, Chiba S
Clin. Exp. Pharmacol. Physiol. 30: 937-942


2002年

Beta-Adrenergic modulation of prepulse facilitation of L-type calcium channels in rabbit ventricular myocytes.
Yamada M
Pflugers Archiv. 444(1-2): 89-98

The role of muscarinic K+ channels in the negative chronotropic effect of a muscarinic agonist.
Yamada M
J. Pharmacol. Exp. Ther. 300(1): 681-687

Partial vagal denervation increases vulnerability to vagally induced atrial fibrillation.
Hirose M, Leatmanorat Z, Laurita KR, Carlson MD
J. Cardiovasc. Electrophysiol. 13: 1272-1279

Cellular mechanisms of vagally-mediated atrial tachyarrhythmia in isolated arterially perfused canine right atria.
Hirose M, Carlson MD, Laurita KR
J. Cardiovasc. Electrophysiol. 13: 918-926

Heterogenous distribution of beta-adrenergic and muscarinic receptors in the sinoatrial node and right atrium of the dog.
Kurogouchi F, Nakane T, Furukawa Y, Hirose M, Inada Y, Chiba S
Clin. Exp. Pharmacol. Physiol. 29: 666-672

Botulinum Neurotoxin A blocks cholinergic ganglionic neurotransmission in the dog heart.
Tsuboi M, Furukawa Y, Kurogouchi F, Nakajima K, Hirose M, Chiba S
Jpn. J. Pharmacol. 89: 249-254