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Department of Molecular Pharmacology |
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Prostanoid EP4 receptor-mediated augmentation of Ih currents in Aΐ dorsal root ganglion neurons underlies neuropathic pain. Zhang H, Kashihara T, Nakada T, Tanaka S, Ishida K, Fuseya S, Kawagishi H, Kiyosawa K, Kawamata M, Yamada M. J. Pharmacol. Exp. Ther. 368:50-58 Effects of hypertension and antihypertensive treatments on sulfatide levels in serum and its metabolism. Guo R, Hu X, Yamada Y, Harada M, Nakajima T, Kashihara T, Yamada M, Aoyama T, Kamijo Y. Hypertension Research in press Sonic hedgehog signaling regulates the mammalian cardiac regenerative response. Kawagishi H, Xiong J, Rovira II, Pan H, Yan Y, Fleischmann BJ, Yamada M, Finkel T. J. Mol. Cell. Cardiol. 123:180-184 PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus. Guo X, Kashihara T, Nakada T, Aoyama T, Yamada M. Pflugers Arch. 470(6):909-921 Physical interaction of junctophilin and the CaV1.1 C terminus is crucial for skeletal muscle contraction. Nakada T, Kashihara T, Komatsu M, Kojima K, Takeshita T, Yamada M. Proc. Natl. Acad. Sci. USA. 115: 4507-4512 Angiotensin II activates CaV 1.2 Ca2+ channels through ΐ-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes. Kashihara T, Nakada T, Kojima K, Takeshita T, Yamada M. J. Physiol. 595: 4207-4225 Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model. Gautam M, Fujita D, Kimura K, Ichikawa H, Izawa A, Hirose M, Kashihara T, Yamada M, Takahashi M, Ikeda U, Shiba Y. J. Mol. Cell. Cardiol. 81: 139-149 Molecular mechanism of junctional membrane-targeting of cardiac and skeletal muscle L-type calcium channels. Nakada T, Yamada M. Nihon Yakurigaku Zasshi. 144: 217-221 Cardiac overexpression of constitutively active GΏq causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice. Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M. PLoS One. 29: e106354 Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts. Hirose M, Shibazaki T, Nakada T, Kashihara T, Yano S, Okamoto Y, Isaji M, Matsushita N, Taira E, Yamada M. Biol. and Pharm. Bull. 37: 1168-1176 ΐ2-Adrenergic and M2-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure. Kashihara T, Hirose M, Shimojo H, Nakada T, Gomi S, Hongoe M, Yamada M. Eur. J. Pharmacol. 724: 122-131 TRPM4 channels mediate hypertonicity-induced, Ca2+-impermeable, Non-selective cation currents in a cervical cancer cell line, HeLa cells. Gomi S, Nakada T, Kashihara T, Ikeda U, Yamada M. Shinshu. Med. J. 62: 33-44 Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system. Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T. Hypertension 61: 341-351 Nicorandil prevents GΏq-induced progressive heart failure and ventricular arrhythmias in transgenic mice. Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Yamada M. PLoS One 7: e52667 Proximal C-terminus of Ώ1C subunits is necessary for junctional membrane-targeting of cardiac L-type calcium channels. Nakada T, Flucher BE, Kashihara T, Sheng X, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Yamada M. Biochem. J. 448: 221-231 KGA-2727, a Novel Selective Inhibitor of a High-Affinity Sodium Glucose Cotransporter (SGLT1), Exhibits Antidiabetic Efficacy in Rodent Models. Shibazaki T, Tomae M, Ishikawa-Takemura Y, Fushimi N, Itoh F, Yamada M, Isaji M. J. Pharmacol. Exp. Ther. 342: 288-296 Two Mechanistically Distinct Effects of Dihydropyridine Nifedipine on CaV1.2 L-Type Ca2+ Channels Revealed by Timothy Syndrome Mutation. Sheng X, Nakada T, Kobayashi M, Kashihara T, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Aoyama T, Yamada M. Eur. J. Pharmacol. 685: 15-23 Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca2+ channel activity through phosphatases in heart failure. Kashihara T, Nakada T, Shimojo H, Horiuchi-Hirose M, Gomi S, Shibazaki T, Sheng X, Hirose M, Hongo M, Yamada M. Am. J. Physiol. Heart Circ. Physiol. 302: H1645-H1654 Diacylglycerol kinase Δ inhibits ventricular tachyarrhythmias in a mouse model of heart failure. Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubota I, Mende U, Yamada M. Circ. J. 75: 2333-2342 Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes. Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, Ueda H, Yamada M. Am. J. Physiol. Heart Circ. Physiol. 300: H978-H988 Acid-Sensing Ion Channels in Blood Volume Regulation. Yamada M. Circ. J. 75: 781-782 Thrombin activates Ca2+-permeating nonselective cation channels through protein kinase C in human umbilical vein endothelial cells. Tsujino N, Nakada T, Tsubouchi K, Kobayashi M, Kawai Y, Yano S, Matsunaga T, Hirose M, Ohmori S, Ohhashi T, Yamada M. Shinshu Med. J. 59: 13-26 Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria. Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M. Int. J. Cardiol. 146: 37-43 Selective Ώ1A-Adrenoceptor Stimulation Induces Muellerfs Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation. Yano S, Hirose M, Nakada T, Nakayama J, Matsuo K, Yamada M. Curr. Eye Res. 35: 363-369 Mitochondrial ATP-sensitive K+ channels, protectors of the heart. Yamada M. J. Physiol. (Lond.) 582: 283-286 Effects of hormone-sensitive lipase-disruption on cardiac energy metabolism in response to fasting and refeeding. Suzuki J, Ueno M, Uno M, Hirose Y, Zenimaru Y, Takahashi S, Osuga JI, Ishibashi S, Takahashi M, Hirose M, Yamada M, Kraemer FB, Miyamori I. Am. J. Physiol. Endocrinol. Metab. 297: E1115-E1124 Diacylglycerol kinase zeta inhibits GΏq-induced atrial remodeling in transgenic mice. Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M. Heart Rhythm. 6: 78-84 Contribution of L-type Ca2+ channels to early afterdepolarizations induced by IKr and IKs channel suppression in guinea-pig ventricular myocytes. Yamada M, Ohta K, Niwa A, Tsujino N, Nakada T, Hirose M. J. Membr. Biol. 222: 151-166 Mechanisms of preventive effect of nicorandil on ischaemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular wedges. Hirose M, Tsujino N, Nakada T, Yano S, Imamura H, Yamada M. Basic Clin. Pharmacol. Toxicol. 102: 504-514 MCP-1 induces cardioprotection against ischaemia/reperfusion injury: role of reactive oxygen species. Morimoto H, Hirose M, Takahashi M, Kawaguchi M, Ise H, Kolattukudy PE, Yamada M, Ikeda U Cardiovasc. Res. 78: 554-62 Mechanisms of the preventive effect of pilsicainide on atrial fibrillation originating from the pulmonary vein. Hirose M, Ohkubo Y, Takano M, Hamazaki M, Sekido T, Yamada M Circ. J. 71:1805-1814 Calcium mediated-triggered activity is an underlying cellular mechanism of ectopy originating from pulmonary vein in canine. Hirose M, Laurita KR Am. J. Physiol. 292: H1861-H1867 Mechanism of atrial tachyarrhythmia induction in a canine model of autonomic tone fluctuation. Hirose M, Imamura H Basic Res. Cardiol. 102: 52-62 Rotigaptide (ZP123) improves atrial conduction slowing in chronic volume overload-induced dilated atria. Haugan K, Miyamoto T, Takeishi Y, Kubota I, Nakayama J, Shimojo H, and Hirose M Basic Clin. Pharmacol. and Toxicol. 99: 71-79 A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K+ channels. Yamada, M. and Kurachi, Y J. Mol. Cell. Cardiol. 39: 1-6 PtdIns(3,4,5)P3 and Ca2+/calmodulin competitively bind to the RGS domain of RGS4 and reciprocally regulate its action. Ishii M, Fujita S, Yamada M, Hosaka Y, Kurachi Y Biochem. J. 385: 65-73 Mechanism for atrial tachyarrhythmia in chronic volume overload-induced dilated atria. Hirose M, Takeishi Y, Miyamoto T, Kubota I, Laurita KR, Chiba S, J. Cardiovasc. Electrophysiol. 16: 760-769 Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K+ channels: Implication for dimerization of nucleotide-binding domains to induce channel opening. Yamada M, Ishii M, Hibino H, Kurachi Y Mol. Pharmacol. 66: 807-816 The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels. Yamada M, Kurachi Y Mol. Pharmacol. 65: 1198-1207 Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes. Hibino H, Fujita A, Iwai K, Yamada M, Kurachi Y J. Biol. Chem.279: 44065-44073 Comparison of kinetic properties of quinidine and dofetilide block of HERG channels. Tsujimae K, Suzuki S, Yamada M, Kurachi Y Eur. J. Pharmacol. 493: 29-40 Effect of Tertiapin on Different Types of Recombinant Inwardly Rectifying Potassium Channels. Makino Y, Matsushita K, Yamashita S, Matsuzawa Y, Yamada M, Kurachi Y Osaka Med. J. |