◎まず日本語で読みたい方へ

平塚 佐千枝.　転移のプラットフォーム 転移前土壌を形成するサイトカイン.
医学のあゆみ. 医歯薬出版株式会社(平塚 佐千枝 監修) 2016, 1201, 1299-1233

平塚 佐千枝. 分子細胞生物学講座「血管透過性と癌の転移」.
月刊（細胞）ニュー・サイエンス社. 2015. 45-48

平塚 佐千枝, 丸 義朗. 転移予定臓器の転移前の土壌 がん転移の機構.
Medical Science Digest (佐谷　秀行編). ニュー・サイエンス社. 2014, 14-17


◎原著

Hayashi H, Seki S, Tomita T, Kato M, Ashihara N, Chano T, Sanjo H, Kawade M, Yan C, Sakai H, Tomida H, Tanaka M, Iwaya M, Taki S, Nakazawa Y, Soejima Y, Ueno Y, Hiratsuka S.(2025)
Synthetic short mRNA prevents metastasis via innate-adaptive immunity.
Nat Commun. 2025 16:1925. doi: https://doi.org/10.1038/s41467-025-57123-y

Han Y, Tomita T, Kato M, Ashihara N, Higuchi Y, Matoba H, Wang W, Hayashi H, Itoh Y, Takahashi S, Kurita H, Nakayama J, Okumura N, Hiratsuka S.(2023)
Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis.
Nat Commun. 2023 14:4960. doi: https://doi.org/10.1038/s41467-023-40371-1

Yin C, Kato M, Tomita T, Han Y, Hiratsuka S.(2023)
Suppression of CEBPδ recovers exhaustion in anti-metastatic immune cells.
Sci Rep. 13:3903. doi: https://doi.org/10.1038/s41598-023-30476-4

Takeshi Tomita, Masayoshi Kato, Taishi Mishima, Yuta Matsunaga, Hideki Sanjo, Ken-Ichi Ito, Kentaro Minagawa, Toshimitsu Matsui, Hiroyuki Oikawa, Satoshi Takahashi, Toshifumi Takao, Noriki Iwai, Takashi Mino, Osamu Takeuchi, Yoshiro Maru, Sachie Hiratsuka.(2021)
Extracellular mRNA transported to the nucleus exerts translation-independent function
Nat. Commun. 12:3655. doi: https://doi.org/10.1038/s41467-021-23969-1

Hiratsuka S., Tomita T., Mishima T., Matsunaga Y., Omori T., Ishibashi S., Yamaguchi S., Hosogane T., Watarai H., Omori-Miyake M., Yamamoto T., Shibata N., Watanabe A., Aburatani H., Tomura M., High. KA., Maru Y. (2018)
Hepato-entrained B220+CD11c+NK1.1+ cells regulate pre-metastatic niche formation in the lung.
EMBO Mol. Med. e8643, doi: 10.15252/emmm.201708643

Lung Tumor Cell Recruitment Assay
Tomita T., Ieguchi K., Deguchi A., Takita M, Tsukahara F., Hiratsuka S., Maru Y. (2018)
Lung Tumor Cell Recruitment Assay.
Journal of Visualized Experiments in press

Hiratsuka S., Ishibashi S., Tomita T., Watanabe A., Akashi-Takamura S., Murakami M., Kijima H., Miyake K., Aburatani H., Maru Y. (2013)
Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci.
Nature Communications 4: Article number: 1853 doi:10.1038/ncomms2856.

Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK. (2011)
Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Proc Natl Acad Sci U S A. 108: 3725-3730.

Hiratsuka S, Duda DG, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, Jain RK. (2011)
C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.
Proc Natl Acad Sci U S A. 108: 302-307.

Hiratsuka S, Watanabe A, Sakurai Y, Akashi-Takamura S, Ishibashi S, Miyake K, Shibuya M, Akira S, Aburatani H, Maru Y. (2008)
The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase.
Nat. Cell Biol. 10: 1349-1355.

Hiratsuka S, Watanabe A, Aburatani H, Maru Y. (2006)
Tumor-mediated upregulation of chemoattractants and recruitment of myeloid cells pre-determines lung metastasis.
Nat. Cell Biol. 8: 1369-1375.

Murakami M, Iwai S, Hiratsuka S, Yamauchi M, Nakamura K, Iwakura Y, Shibuya M. (2006)
Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages.
Blood. 108: 1849-1856.

Niida S, Kondo T, Hiratsuka S, Hayashi S, Amizuka N, Noda T, Ikeda K, Shibuya M. (2005)
VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice.
Proc Natl Acad Sci U S A 102: 14016-14021.

Hiratsuka S, Nakao K, Nakamura K, Katsuki M, Maru Y, Shibuya M. (2005)
Related Membrane fixation of vascular endothelial growth factor receptor 1 ligand-binding domain is important for vasculogenesis and angiogenesis in mice.
Mol Cell Biol. 25: 346-354.

Hiratsuka S, Kataoka Y, Nakao K, Nakamura K, Morikawa S, Tanaka S, Katsuki M, Maru Y, Shibuya M. (2005)
Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos.
Mol Cell Biol. 25: 355-363.

Hiratsuka S, Nakamura K, Iwai S, Murakami M, Itoh T, Kijima H, Shipley JM, Senior RM, Shibuya M. (2002)
Involvement of MMP9 induction by Vascular Endothelial Growth Factor Receptor-1 in lung specific metastasis.
Cancer Cell 2 : 289-300.

Hiratsuka S, Maru Y, Okada A, Seiki M, Noda T, Shibuya M. (2001)
Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis.
Cancer Research 61: 1207-1213.

Hiratsuka S, Minowa O, Kuno J, Noda T, Shibuya M. (1998)
Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice.
Proc Natl Acad Sci U S A 95 : 9349-9354.

Kondo K, Hiratsuka S, Subbalakshmi E, Matsushime H, Shibuya M. (1998)
Genomic organization of the flt-1 gene encoding for Vascular Endothelial Growth Factor (VEGF) Receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors.
Gene 208 : 297-305.

Hiratsuka S, Yoshida A, Kimata H. (1996)
Enhancement of in vitro spontaneous IgE production by topical steroid in patients with atopic dermatitis.
Journal of Allergy and Clinical Immunology 98:107-113.

Kimata H, and Hiratsuka S. (1994)
Effect of topical cromoglycate solution on atopic dermatitis: combined treatment of sodium cromoglycate solution with the oral anti-allergic medication, oxatomide.
European Journal of Pediatrics 153: 66-71.


◎総説

Takeshi Tomita, Masayoshi Kato, Taishi Mishima, Sachie Hiratsuka.(2021)
Regulation of vascular permeability in cancer metastasis
Cancer Sci. doi: 10.1111/cas.14942. Online ahead of print.

David Lyden, Hector Peinado, Haiying Zhang, Irina Matei, Bruno Costa-Silva, Hoshino Ayuko, Goncalo Rodrigues, Bethan Psaila, Rosandra Kaplan, Jacqueline Bromberg, Yibin Kang, Mina Bissell, Thomas Cox, Amato Giaccia, Janine Erler, Sachie Hiratsuka, and Cyrus Ghajar
Pre-metastatic niches: organ-specific homes for metastases (2017)
Nature Reviews Cancer, NRC-11-148V4

Hiratsuka S.
Establishment of diagnosis for early metastasis. "Chronic Inflammation: Elucidation and Control of the Mechanisms" (2016)
Springer, Journal of Biomedical Science 978-4-431-56066