学術論文/Research articles(Journal Citation Reports 収録誌)

「*」印:責任著者, corresponding author
印刷中
51. Namai, F., Shigemori, S., Sudo, K., Sato, T., Yamamoto, Y., Nigar, S., Ogita, T. & Shimosato, T.*
Recombinant mouse osteocalcin secreted by Lactococcus lactis promotes glucagon-like peptide-1 induction in STC-1 cells
Current Microbiology, --, 2018.
DOI:10.1007/s00284-017-1354-3
2018


2017
50. Nigar, S., Yamamoto, Y., Okajima, T., Shigemori, S., Sato, T., Ogita, T. & Shimosato, T.*
Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
BMC Immunology, 18:44, 2017.
DOI:10.1186/s12865-017-0227-7


49. Yamamoto, Y., Sugimura, R., Watanabe, T., Shigemori, S., Okajima, T., Nigar, S., Namai, F., Sato, T., Ogita, T. & Shimosato, T.*
Class A CpG oligonucleotide priming rescues mice from septic shock via activation of platelet-activating factor acetylhydrolase
Frontiers in Immunology, 8, ID:1049, 2017.
DOI:10.3389/fimmu.2017.01049

48. Shigemori, S.,Namai, F., Yamamoto, Y., Nigar, S., Sato, T., Ogita, T. & Shimosato, T.*
Genetically modified Lactococcus lactis producing a green fluorescence protein-bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in LPS-stimulated RAW 264.7
Journal of Dairy Science, 100(9), 7007-7015, 2017.
Editor's choice(特集論文)に選定.

47. Shigemori, S. & Shimosato, T.*
Applications of genetically modified immunobiotics with high immunoregulatory capacity for treatment of inflammatory bowel diseases
Frontiers in Immunology, 8, 22, 2017.
DOI:10.3389/fimmu.2017.00022

46. Shigemori, S., Ihara, M., Sato, T., Yamamoto, Y., Nigar, S., Ogita, T. & Shimosato, T.*
Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis
Applied Microbiology and Biotechnology
, 101(1), 341-349, 2017.
DOI:10.1007/s00253-016-7907-8

2016
45. Klinman, D.M.*, Sato, T. & Shimosato, T.
The use of nanoparticles to delivery immunomodulatory oligonucleotides
Wiley Interdisciplinary Reviews(WIREs): Nanomedicine andNanobiotechnology, 8(4), 631-637, 2016.
DOI:10.1002/wnan.1382

44. Yamamoto, Y., Shigemori, S., Nigar, S., Oshiro, K., Wang, Y., Sato, T. & Shimosato, T.*
Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide fromStreptococcus thermophilus
Animal Science Journal, 87(5), 710-717, 2016.

DOI:10.1111/asj.12479


2015
43.Shigemori, S., Watanabe, T., Kudo, K., Ihara, M., Nigar, S., Yamamoto, Y., Sato, T., Kitazawa, H., & Shimosato, T.*
Oral delivery ofLactococcus lactisthat secretes bioactive heme
oxygenase-1 alleviates development of acute colitis in mice
Microbial Cell Factories, 14(1), 189, 2015.
DOI:10.1186/s12934-015-0378-2

42.Sato, T., Shimosato, T., Ueda, A., Ishigatsubo, Y. & Klinman, D.M.*
Intrapulmonary delivery of CpG microparticles eliminates lung tumors
Molecular CancerTherapeutics, 14(10), 2198-2205, 2015.

DOI:10.1158/1535-7163.MCT-15-0401

41. Uyeno, Y.*, Shigemori, S. & Shimosato, T.
Effect of probiotics/prebiotics on cattle health and productivity
Microbes and Environments,30(2), 126-132, 2015.

DOI:10.1264/jsme2.ME14176

40. Tokutake, Y., Gushima, K., Miyazaki, H., Shimosato, T. & Yonekura S.*
ALS-associated P56S-VAPB mutation restrains 3T3-L1 preadipocyte differentiation
Biochemical and Biophysical Research Communications,460(3), 831-837, 2015.

DOI:10.1016/j.bbrc.2015.03.118

39. Wang, Y., Yamamoto, Y., Shigemori, S., Watanabe, T., Oshiro, K., Wang, X., Wang, P., Sato, T., Yonekura, S., Tanaka, S., Kitazawa, H. & Shimosato, T.*
Inhibitory/Suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice
Molecular Therapy, 23(2), 297-309, 2015.

DOI:10.1038/mt.2014.239
Featured Articles(特集論文)に選定. DOI:10.1038/mt.2014.249
Commentary: Klinman DM.
Therapeutic implications of orally delivered immunomodulatory oligonucleotides
Molecular Therapy, 23(2):222-223, 2015.

DOI:10.1038/mt.2014.251


2014
38. Shigemori, S., Ohshiro, K., Wang, P., Yamamoto, Y., Wang, Y., Sato, T., Uyeno, Y. & Shimosato, T.*
Generation of dipeptidyl peptidase-IV-inhibiting peptidesfrom β-lactoglobulin secreted byLactococcuslactis
BioMed Research International, 2014:393598, 2014.
DOI:10.1155/2014/393598

37. Shimosato, T.*,
Kanoh, J. & Otani, H.
Oral administration of a fruiting body extract ofBoletopsis leucomelasenhances intestinal IgA production in LPS-challenged mice
Food and Agricultural Immunology, 25(4), 510-522, 2014. DOI:10.1080/09540105.2013.847064

36. Watanabe, T., Nishimura, K., Hosaka, Y., Shimosato, T., Yonekura, S., Suzuki, D., Takemoto, C., Monir, MM. & Hiramatsu, K.*
Histological analysis of glucagon-like peptide-1 receptor expression in chicken pancreas
Cell and Tissue Research,357(1), 55-61, 2014.
DOI: 10.1007/s00441-014-1836-6
.

2013
35. Shigemori, S., Yonekura, S., Sato, T., Otani, H. & Shimosato, T.*
Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis
Applied Microbiology and Biotechnology, 97(8), 3603-3611, 2013.
DOI: 10.1007/s00253-012-4608-9


34. Takahashi, R., Sato, T., Klinman, DM., Shimosato, T., Kaneko, T. & Ishigatsubo, Y.*
Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells
International Journal of Oncology, 42(2), 429-436, 2013.
DOI:10.3892/ijo.2012.1755


33. Ito, Y.,Shigemori, S., Sato, T., Shimazu, T.,Konomi, H., Otani, H., Kitazawa, H. & Shimosato, T.*
Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression
FEBS Open Bio,3, 41-45, 2013.
DOI: 10.1016/j.fob.2012.11.002


2012
32. Sato, T., Saito, Y., Inoue, S., Shimosato, T., Takagi, S., Kaneko, T. & Ishigatsubo, Y.*
Serum heme oxygenase-1 as a marker of lung function decline in patients with chronic silicosis
Journal of Occupational and Environmental Medicine, 54, 1461-1466, 2012.
DOI: 10.1097/JOM.0b013e3182636e93


31. Ikuno, Y., Banno, M., Shimosato, T.& Otani H.*
Oral administration of a casein phosphopeptide and phosphorylated dextrin preparations enhances intestinal IgA production and gene expression relating to the IgA production and calcium absorption in mice.
Milchwissenschaft-Milk Science International,67, 289-292, 2012.


30. Shigemori, S., Yonekura, S., Sato, T.,Nakanishi, M., Otani, H. & Shimosato, T.*
Expression of a biologically active GFP-αS1-casein fusion protein in Lactococcus lactis.
Current Microbiology, 64(6), 569-575, 2012.
DOI: 10.1007/s00284-012-0111-x


29. Shimazu, T., Villena, J., Tohno, M., Fujie, H., Hosoya, S., Shimosato, T., Aso, H., Suda, Y., Kawai, Y., Saito, T., Makino, S., Ikegami, S., Itoh, H. & Kitazawa, H.*
Immunobiotic Lactobacillus jensenii elicits anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the Toll-like receptor signaling pathway.
Infection and Immunity, 80, 276-288, 2012.
DOI: 10.1128/IAI.05729-11

2011
28. Tohno, M., Shimosato, T., Aso, H. & Kitazawa, H.*
Immunobiotic Lactobacillus strains augment NLRP3 expression in newborn and adult porcine gut-associated lymphoid tissues
Veterinary Immunology and Immunopathology
144, 410-416, 2011.
DOI: 10.1016/j.vetimm.2011.09.010


27. Shimosato, T.*, Tomida, K. & Otani, H.
Effect of Lactobacillus pentosus ONRIC b0240 on intestinal IgA production in mice fed differing levels of protein
Journal of Agricultural and Food Chemistry
59, 2646-2651, 2011.
DOI: 10.1021/jf104240d


26. Sekimura, Y., Shimosato, T.& Otani, H.* Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat's milk immunoglobulin G rich fraction on ovalbumin sensitized BALB/c mice
Milchwissenschaft-Milk Science International, 66, 7-10, 2011.


25. Hosoya, S., Villena, J., Shimazu, T., Tohno, M., Fujie, H., Chiba, E., Shimosato, T., Aso, H., Suda, Y., Kawai, Y., Saito, T., Alvarez, S., Ikegami, S., Itoh, H. & Kitazawa, H.*
Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells
Veterinary Research, 42, 111, 2011.
DOI: 10.1186/1297-9716-42-111


24. Fujie, H., Villena, J., Tohno, M., Morie, K., Shimazu, T., Aso, H., Suda, Y., Shimosato, T., Iwabuchi, N., Xiao, J. Z., Yaeshima, T., Iwatsuki, K., Saito, T., Numasaki, M. & Kitazawa, H.
Toll-like receptor-2-activating bifidobacteria strains differentially regulate inflammatory cytokines in the porcine intestinal epithelial cell culture system: finding new anti-inflammatory immunobiotics
FEMS Immunology and Medical Microbiology, 63, 129-39, 2011.
DOI: 10.1111/j.1574-695X.2011.00837.x

2010
23. Shimosato, T.*, Fujimoto, M., Tohno, M., Sato, T.,Tateo, M., Otani, H. & Kitazawa, H.
CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9.
Biochemical and Biophysical Research Communications, 394, 81-86, 2010.
DOI: 10.1016/j.bbrc.2010.02.110


22. Sato, T., Yamamoto, M., Shimosato, T. & Klinman, D.M.*
Accelerated wound healing mediated by activation of Toll-like receptor 9
Wound Repair and Regeneration, 18, 586-593, 2010.
DOI: 10.1111/j.1524-475X.2010.00632.x


21. Nagasawa, C., Nishimura-Uemura, J., Tohno, M., Shimosato, T., Kawai, Y., Ikegami, S., Oda, M., Saito, T. & Kitazawa, H.*
Oral Administration of Phosphorylated Dextran Regulates Immune Response in Ovalbumin-Immunized Mice
Asian-Australasian Journal of Animal Sciences, 23, 106-115, 2010.

2009
20. Shimosato, T.*, Tohno, M., Sato, T., Nishimura, J., Kawai, Y., Saito, T. & Kitazawa, H.
Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ.
Animal Science Journal, 80, 597-604, 2009.
DOI: 10.1111/j.1740-0929.2009.00680.x


19. Shimazu, T., Tohno, M., Katoh, S., Shimosato, T., Aso, H., Kawai, Y., Saito, T. & Kitazawa, H.*
Utilization of the porcine system to study lymphotoxin-beta regulation in intestinal lymphoid tissue
Biochemical Genetics, 47, 126-136, 2009.
DOI: 10.1007/s10528-008-9212-4

2008
18. Kitazawa, H.*, Tohno, M., Shimosato, T. &Saito T.
Development of molecular immunoassay system for probiotics via toll-like receptors based on food immunology
Animal Science Journal. 2008, 79(1): 11-21.

17. Sato, T., Shimosato, T., Alvord, W. G. & Klinman, D. M.*
Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation
Journal ofImmunology, 180, 7648-7654, 2008.


16. Iliev, I. D., Tohno, M., Kurosaki, D., Shimosato, T., He, F., Hosoda, M., Saito, T. & Kitazawa, H.*
Immunostimulatory oligodeoxynucleotide containingTTTCGTTT motif from Lactobacillus rhamnosus GG DNA potentially suppresses OVA-specific IgE production in mice
Scandinavian Journal of Immunology,67, 370-376, 2008.

2007
15. Tohno, M., Shimosato, T., Kawai, Y., Aso, H., Ikegami, S., Taketomo, N., Saito, T. & Kitazawa, H.*
Advanced molecular immunoassay system for immunobiotic lacticacid bacteria using a transfectant of Toll-like receptor 2
Animal Science Journal, 78, 195-205, 2007.


14. Kitazawa, H.*, Yonezawa, K., Tohno, M., Shimosato, T., Kawai, Y., Saito, T. & Wang, J. M.
Enzymatic digestion of the milk protein beta-casein releases potentchemotactic peptide(s) for monocytes and macrophagesInternational Immunopharmacology, 7, 1150-1159, 2007.

2006
13. Tohno, M.,Shimosato, T., Moue, M., Aso, H., Watanabe, K., Kawai, Y., Yamaguchi, T., Saito, T. & Kitazawa, H.*
Toll-like receptor 2 and 9 are expressed and functional in gut-associated lymphoid tissues of presuckling newborn swine
Veterinary Research, 37, 791-812, 2006.


12. Takahashi, N., Kitazawa, H.*, Shimosato, T., Iwabuchi, N., Xiao, J. Z., Iwatsuki, K., Kokubo, S. & Saito, T.
An immunostimulatory DNA sequence from a probiotic strain of Bifidobacterium longum inhibits IgE production in vitro
FEMS Immunology and Medical Microbiology, 46, 461-469, 2006.


11. Shimosato, T., Kimura, T., Tohno, M., Iliev, I. D., Katoh, S., Ito, Y., Kawai, Y., Sasaki, T., Saito, T. & Kitazawa, H.*
Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5 '-C...G-3 ' stem structure
Cellular Microbiology, 8, 485-495, 2006.

2005
10. Tohno, M., Shimosato, T.(co-first author), Kitazawa, H.*, Katoh, S., Iliev, I. D., Kimura, T., Kawai, Y., Watanabe, K., Aso, H., Yamaguchi, T. & Saito, T.
Toll-like receptor 2 is expressed on the intestinal M cells in swine
Biochemical and Biophysical Research Communications, 330, 547-554, 2005.


9. Tohno, M., Kitazawa, H.*, Shimosato, T., Matsumoto, M., Katoh, S., Kawai, Y. & Saito, T.
A swine toll-like receptor 2-expressing transfectant as a potential primary screening system for immunobiotic microorganisms
FEMS Immunology and Medical Microbiology, 44, 283-288, 2005.


8. Shimosato, T., Tohno, M., Kitazawa, H.*, Katoh, S., Watanabe, K., Kawai, Y., Aso, H., Yamaguchi, T. & Saito, T.
Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer's patches
Immunology Letters, 98, 83-89, 2005.


7. Shimosato, T., Kitazawa, H.*, Katoh, S., Tohno, M., Iliev, I. D., Nagasawa, C., Kimura, T., Kawai, Y. & Saito, T.
Augmentation of TH-1 type response by immunoactive AT oligonucleotide from lactic acid bacteria via Toll-like receptor 9 signaling.
Biochemical and Biophysical Research Communications, 326, 782-787, 2005.


6. Iliev, I. D., Kitazawa, H.*, Shimosato, T., Katoh, S., Morita, H., He, F., Hosoda, M. & Saito, T.
Strong immunostimulation in murine immune cells by Lactobacillus rhamnosus GG DNA containing novel oligodeoxynucleotide pattern
Cellular Microbiology, 7, 403-414, 2005.

2004
5.Shimosato, T., Kitazawa, H.*, Tohno, M., Katoh, S., Kawai, Y. & Saito, T.
Development of immune assay system for both CpG and non-CpG DNA from lactic acid bacteria using a transfectant of swine Toll-like receptor 9
Animal Science Journal, 75, 377-382, 2004.

4. Sato, T., Nishimura-Uemura, J.,Shimosato, T., Kawai, Y., Kitazawa, H. & Saito, T.*
Dextran from Leuconostoc mesenteroides augments immunostimulatory effects by the introduction of phosphate groups
Journal of Food Protection, 67, 1719-1724, 2004.


3. Katoh, S., Kitazawa, H.*, Shimosato, T., Tohno, M., Kawai, Y. & Saito, T.
Cloning and characterization of swine interleukin-17, preferentially expressed in the intestines
Journal of Interferon and Cytokine Research, 24, 553-559, 2004.

2003
2. Shimosato, T., Kitazawa, H.*, Katoh, S., Tomioka, Y., Karima, R., Ueha, S., Kawai, Y., Hishinuma, T., Matsushima, K. & Saito, T.
Swine Toll-like receptor 9 recognizes CpG motifs of human cell stimulant
Biochimica et Biophysica Acta-Gene Structure and Expression, 1627, 56-61, 2003.


1. Kitazawa, H.*, Watanabe, H., Shimosato, T., Kawai, Y., Itoh, T. & Saito, T.
Immunostimulatory oligonucleotide, CpG-like motif exists in Lactobacillus delbrueckii ssp bulgaricus NIAI B6
International Journal of Food Microbiology, 85, 11-21, 2003.