学術論文/Research articles(Journal Citation Reports 収録誌)

    • 「*」印:責任著者/Corresponding author
  • 印刷中
    • 55. Koyama, S., Fujita, H.*, Shimosato, T., Kamijo, A., Ishiyama, Y., Yamamoto, E., Ishii, Y., Hattori, Y., Hagiwara, M., Yamazaki, E., Tomita, N. & Nakajima, H. Septicemia from Lactobacillus rhamnosus GG, from a Probiotic Enriched Yogurt, in a Patient with Autologous Stem Cell Transplantation
      Probiotics and Antimicrobial Proteins, in press.
      DOI:10.1007/s12602-018-9399-6
  • 2018
    • 54. Namai, F., Yamamoto, Y., Sato, T., Ogita, T. & Shimosato, T.*
      Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages
      Animal Science Journal, 89(12), 1707-1711, 2018. DOI:10.1111/asj.13115

      53. Nigar, S., Yamamoto, Y., Okajima, T., Sato, T., Ogita, T. & Shimosato, T.*
      Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components
      Animal Science Journal, 89(10), 1504-1511, 2018.
      DOI: 10.1111/asj.13082

      52. Nakashima, K., Sato, T.*, Shigemori, S., Shimosato, T., Shinkai, M., Kaneko, T.
      Regulatory Role of Heme Oxygenase-1 in Silica-induced Lung Injury
      Respiratory Research, 19:144, 2018.
      DOI: 10.1186/s12931-018-0852-6

      51. Namai, F., Shigemori, S., Sudo, K., Sato, T., Yamamoto, Y., Nigar, S., Ogita, T. & Shimosato, T.*
      Recombinant mouse osteocalcin secreted by Lactococcus lactis promotes glucagon-like peptide-1 induction in STC-1 cells
      Current Microbiology, 75(1), 92-98, 2018.
      DOI:10.1007/s00284-017-1354-3
  • 2017
    • 50. Nigar, S., Yamamoto, Y., Okajima, T., Shigemori, S., Sato, T., Ogita, T. & Shimosato, T.*
      Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
      BMC Immunology, 18(1):44, 2017.
      DOI:10.1186/s12865-017-0227-7

      49. Yamamoto, Y., Sugimura, R., Watanabe, T., Shigemori, S., Okajima, T., Nigar, S., Namai, F., Sato, T., Ogita, T. &Shimosato, T.*
      Class A CpG oligonucleotide priming rescues mice from septic shock via activation of platelet-activating factor acetylhydrolase
      Frontiers in Immunology, 8, ID:1049, 2017.
      DOI:10.3389/fimmu.2017.01049

      48. Shigemori, S., Namai, F., Yamamoto, Y., Nigar, S., Sato, T., Ogita, T. & Shimosato, T.* Genetically modified Lactococcus lactis producing a green fluorescence protein-bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in LPS-stimulated RAW 264.7
      Journal of Dairy Science, 100(9), 7007-7015, 2017.
      Editor's choice(特集論文)

      47. Shigemori, S. & Shimosato, T.*
      Applications of genetically modified immunobiotics with high immunoregulatory capacity for treatment of inflammatory bowel diseases
      Frontiers in Immunology, 8, 22, 2017.
      DOI:10.3389/fimmu.2017.00022

      46. Shigemori, S., Ihara, M., Sato, T., Yamamoto, Y., Nigar, S., Ogita, T. & Shimosato, T.* Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis
      Applied Microbiology and Biotechnology
      , 101(1), 341-349, 2017.
      DOI:10.1007/s00253-016-7907-8
  • 2016
    • 45. Klinman, D.M.*, Sato, T. & Shimosato, T.
      The use of nanoparticles to delivery immunomodulatory oligonucleotides
      Wiley Interdisciplinary Reviews(WIREs): Nanomedicine and Nanobiotechnology, 8(4), 631-637, 2016.(総説)
      DOI:10.1002/wnan.1382

      44. Yamamoto, Y., Shigemori, S., Nigar, S., Oshiro, K., Wang, Y., Sato, T. & Shimosato, T.*
      Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus
      Animal Science Journal, 87(5), 710-717, 2016.
      DOI:10.1111/asj.12479
  • 2015
    • 43. Shigemori, S., Watanabe, T., Kudo, K., Ihara, M., Nigar, S., Yamamoto, Y., Sato, T., Kitazawa, H., & Shimosato, T. *
      Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice
      Microbial Cell Factories, 14(1), 189, 2015.
      DOI:10.1186/s12934-015-0378-2

      42. Sato, T., Shimosato, T., Ueda, A., Ishigatsubo, Y. & Klinman, D.M.*
      Intrapulmonary delivery of CpG microparticles eliminates lung tumors
      Molecular Cancer Therapeutics, 14(10), 2198-2205, 2015.
      DOI:10.1158/1535-7163.MCT-15-0401

      41. Uyeno, Y.*, Shigemori, S. & Shimosato, T.
      Effect of probiotics/prebiotics on cattle health and productivity
      Microbes and Environments, 30(2), 126-132, 2015. (総説)
      DOI:10.1264/jsme2.ME14176

      40. Tokutake, Y., Gushima, K., Miyazaki, H., Shimosato, T. & Yonekura S.*
      ALS-associated P56S-VAPB mutation restrains 3T3-L1 preadipocyte differentiation
      Biochemical and Biophysical Research Communications, 460(3), 831-837, 2015.
      DOI:10.1016/j.bbrc.2015.03.118

      39. Wang, Y., Yamamoto, Y., Shigemori, S., Watanabe, T., Oshiro, K., Wang, X., Wang, P., Sato, T., Yonekura, S., Tanaka, S., Kitazawa, H. & Shimosato, T. *
      Inhibitory/Suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice
      Molecular Therapy, 23(2), 297-309, 2015.
      DOI:10.1038/mt.2014.239
      Featured Articles(特集論文). DOI:10.1038/mt.2014.249
      Commentary: Klinman DM.
      Therapeutic implications of orally delivered immunomodulatory oligonucleotides
      Molecular Therapy, 23(2):222-223, 2015.
      DOI:10.1038/mt.2014.251
  • 2014
    • 38. Shigemori, S., Ohshiro, K., Wang, P., Yamamoto, Y., Wang, Y., Sato, T., Uyeno, Y. & Shimosato, T.*
      Generation of dipeptidyl peptidase-IV-inhibiting peptides from β-lactoglobulin secreted by Lactococcus lactis
      BioMed Research International, 2014:393598, 2014.
      DOI:10.1155/2014/393598

      37. Shimosato, T.*, Kanoh, J. & Otani, H.
      Oral administration of a fruiting body extract of Boletopsis leucomelas enhances intestinal IgA production in LPS-challenged mice
      Food and Agricultural Immunology, 25(4), 510-522, 2014. DOI:10.1080/09540105.2013.847064

      36. Watanabe, T., Nishimura, K., Hosaka, Y., Shimosato, T., Yonekura, S., Suzuki, D., Takemoto, C., Monir, MM. & Hiramatsu, K.*
      Histological analysis of glucagon-like peptide-1 receptor expression in chicken pancreas
      Cell and Tissue Research, 357(1), 55-61, 2014.
      DOI: 10.1007/s00441-014-1836-6.
  • 2013
    • 35. Shigemori, S., Yonekura, S., Sato, T., Otani, H. & Shimosato, T.*
      Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis
      Applied Microbiology and Biotechnology, 97(8), 3603-3611, 2013.
      DOI: 10.1007/s00253-012-4608-9

      34. Takahashi, R., Sato, T., Klinman, DM., Shimosato, T., Kaneko, T. & Ishigatsubo, Y.*
      Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells
      International Journal of Oncology, 42(2), 429-436, 2013.
      DOI:10.3892/ijo.2012.1755

      33. Ito, Y., Shigemori, S., Sato, T., Shimazu, T., Konomi, H., Otani, H., Kitazawa, H. & Shimosato, T.*
      Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression
      FEBS Open Bio, 3, 41-45, 2013.
      DOI: 10.1016/j.fob.2012.11.002
  • 2012
    • 32. Sato, T., Saito, Y., Inoue, S., Shimosato, T., Takagi, S., Kaneko, T. & Ishigatsubo, Y.*
      Serum heme oxygenase-1 as a marker of lung function decline in patients with chronic silicosis
      Journal of Occupational and Environmental Medicine, 54, 1461-1466, 2012.
      DOI: 10.1097/JOM.0b013e3182636e93

      31. Ikuno, Y., Banno, M., Shimosato, T. & Otani H.*
      Oral administration of a casein phosphopeptide and phosphorylated dextrin preparations enhances intestinal IgA production and gene expression relating to the IgA production and calcium absorption in mice.
      Milchwissenschaft-Milk Science International, 67, 289-292, 2012.

      30. Shigemori, S., Yonekura, S., Sato, T., Nakanishi, M., Otani, H. & Shimosato, T.*
      Expression of a biologically active GFP-αS1-casein fusion protein in Lactococcus lactis.
      Current Microbiology, 64(6), 569-575, 2012.
      DOI: 10.1007/s00284-012-0111-x

      29. Shimazu, T., Villena, J., Tohno, M., Fujie, H., Hosoya, S., Shimosato, T., Aso, H., Suda, Y., Kawai, Y., Saito, T., Makino, S., Ikegami, S., Itoh, H. & Kitazawa, H.*
      Immunobiotic Lactobacillus jensenii elicits anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the Toll-like receptor signaling pathway.
      Infection and Immunity, 80, 276-288, 2012.
      DOI: 10.1128/IAI.05729-11
  • 2011
    • 28. Tohno, M., Shimosato, T., Aso, H. & Kitazawa, H.*
      Immunobiotic Lactobacillus strains augment NLRP3 expression in newborn and adult porcine gut-associated lymphoid tissues
      Veterinary Immunology and Immunopathology
      144, 410-416, 2011.
      DOI: 10.1016/j.vetimm.2011.09.010

      27. Shimosato, T.*, Tomida, K. & Otani, H.
      Effect of Lactobacillus pentosus ONRIC b0240 on intestinal IgA production in mice fed differing levels of protein
      Journal of Agricultural and Food Chemistry
      59, 2646-2651, 2011.
      DOI: 10.1021/jf104240d

      26. Sekimura, Y., Shimosato, T. & Otani, H.* Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat's milk immunoglobulin G rich fraction on ovalbumin sensitized BALB/c mice
      Milchwissenschaft-Milk Science International, 66, 7-10, 2011.

      25. Hosoya, S., Villena, J., Shimazu, T., Tohno, M., Fujie, H., Chiba, E., Shimosato, T., Aso, H., Suda, Y., Kawai, Y., Saito, T., Alvarez, S., Ikegami, S., Itoh, H. & Kitazawa, H.*
      Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells
      Veterinary Research, 42, 111, 2011.
      DOI: 10.1186/1297-9716-42-111

      24. Fujie, H., Villena, J., Tohno, M., Morie, K., Shimazu, T., Aso, H., Suda, Y., Shimosato, T., Iwabuchi, N., Xiao, J. Z., Yaeshima, T., Iwatsuki, K., Saito, T., Numasaki, M. & Kitazawa, H.
      Toll-like receptor-2-activating bifidobacteria strains differentially regulate inflammatory cytokines in the porcine intestinal epithelial cell culture system: finding new anti-inflammatory immunobiotics
      FEMS Immunology and Medical Microbiology, 63, 129-39, 2011.
      DOI: 10.1111/j.1574-695X.2011.00837.x
  • 2010
    • 23. Shimosato, T.*, Fujimoto, M., Tohno, M., Sato, T., Tateo, M., Otani, H. & Kitazawa, H.
      CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9.
      Biochemical and Biophysical Research Communications, 394, 81-86, 2010.
      DOI: 10.1016/j.bbrc.2010.02.110

      22. Sato, T., Yamamoto, M., Shimosato, T. & Klinman, D.M.*
      Accelerated wound healing mediated by activation of Toll-like receptor 9
      Wound Repair and Regeneration, 18, 586-593, 2010.
      DOI: 10.1111/j.1524-475X.2010.00632.x

      21. Nagasawa, C., Nishimura-Uemura, J., Tohno, M., Shimosato, T., Kawai, Y., Ikegami, S., Oda, M., Saito, T. & Kitazawa, H.*
      Oral Administration of Phosphorylated Dextran Regulates Immune Response in Ovalbumin-Immunized Mice
      Asian-Australasian Journal of Animal Sciences, 23, 106-115, 2010.
  • 2009
    • 20. Shimosato, T.*, Tohno, M., Sato, T., Nishimura, J., Kawai, Y., Saito, T. & Kitazawa, H.
      Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ.
      Animal Science Journal, 80, 597-604, 2009.
      DOI: 10.1111/j.1740-0929.2009.00680.x

      19. Shimazu, T., Tohno, M., Katoh, S., Shimosato, T., Aso, H., Kawai, Y., Saito, T. & Kitazawa, H.*
      Utilization of the porcine system to study lymphotoxin-beta regulation in intestinal lymphoid tissue
      Biochemical Genetics, 47, 126-136, 2009.
      DOI: 10.1007/s10528-008-9212-4
  • 2008
    • 18. Kitazawa, H.*, Tohno, M., Shimosato, T. & Saito T.
      Development of molecular immunoassay system for probiotics via toll-like receptors based on food immunology
      Animal Science Journal, 79(1): 11-21, 2008. (総説)

      17. Sato, T., Shimosato, T., Alvord, W. G. & Klinman, D. M.*
      Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation
      Journal of Immunology, 180, 7648-7654, 2008.

      16. Iliev, I. D., Tohno, M., Kurosaki, D., Shimosato, T., He, F., Hosoda, M., Saito, T. & Kitazawa, H.*
      Immunostimulatory oligodeoxynucleotide containing TTTCGTTT motif from Lactobacillus rhamnosus GG DNA potentially suppresses OVA-specific IgE production in mice
      Scandinavian Journal of Immunology, 67, 370-376, 2008.
  • 2007
    • 15. Tohno, M., Shimosato, T., Kawai, Y., Aso, H., Ikegami, S., Taketomo, N., Saito, T. & Kitazawa, H.*
      Advanced molecular immunoassay system for immunobiotic lactic acid bacteria using a transfectant of Toll-like receptor 2
      Animal Science Journal, 78, 195-205, 2007.

      14. Kitazawa, H.*, Yonezawa, K., Tohno, M., Shimosato, T., Kawai, Y., Saito, T. & Wang, J. M.
      Enzymatic digestion of the milk protein beta-casein releases potent chemotactic peptide(s) for monocytes and macrophages
      International Immunopharmacology, 7, 1150-1159, 2007.
  • 2006
    • 13. Tohno, M., Shimosato, T., Moue, M., Aso, H., Watanabe, K., Kawai, Y., Yamaguchi, T., Saito, T. & Kitazawa, H.*
      Toll-like receptor 2 and 9 are expressed and functional in gut-associated lymphoid tissues of presuckling newborn swine
      Veterinary Research, 37, 791-812, 2006.

      12. Takahashi, N., Kitazawa, H.*, Shimosato, T., Iwabuchi, N., Xiao, J. Z., Iwatsuki, K., Kokubo, S. & Saito, T.
      An immunostimulatory DNA sequence from a probiotic strain of Bifidobacterium longum inhibits IgE production in vitro
      FEMS Immunology and Medical Microbiology, 46, 461-469, 2006.

      11. Shimosato, T., Kimura, T., Tohno, M., Iliev, I. D., Katoh, S., Ito, Y., Kawai, Y., Sasaki, T., Saito, T. & Kitazawa, H.*
      Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5 '-C...G-3 ' stem structure
      Cellular Microbiology, 8, 485-495, 2006.
  • 2005
    • 10. Tohno, M., Shimosato, T.(co-first author), Kitazawa, H.*, Katoh, S., Iliev, I. D., Kimura, T., Kawai, Y., Watanabe, K., Aso, H., Yamaguchi, T. & Saito, T.
      Toll-like receptor 2 is expressed on the intestinal M cells in swine
      Biochemical and Biophysical Research Communications, 330, 547-554, 2005.

      9. Tohno, M., Kitazawa, H.*, Shimosato, T., Matsumoto, M., Katoh, S., Kawai, Y. & Saito, T.
      A swine toll-like receptor 2-expressing transfectant as a potential primary screening system for immunobiotic microorganisms
      FEMS Immunology and Medical Microbiology, 44, 283-288, 2005.

      8. Shimosato, T., Tohno, M., Kitazawa, H.*, Katoh, S., Watanabe, K., Kawai, Y., Aso, H., Yamaguchi, T. & Saito, T.
      Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer's patches
      Immunology Letters, 98, 83-89, 2005.

      7. Shimosato, T., Kitazawa, H.*, Katoh, S., Tohno, M., Iliev, I. D., Nagasawa, C., Kimura, T., Kawai, Y. & Saito, T.
      Augmentation of TH-1 type response by immunoactive AT oligonucleotide from lactic acid bacteria via Toll-like receptor 9 signaling.
      Biochemical and Biophysical Research Communications, 326, 782-787, 2005.

      6. Iliev, I. D., Kitazawa, H.*, Shimosato, T., Katoh, S., Morita, H., He, F., Hosoda, M. & Saito, T.
      Strong immunostimulation in murine immune cells by Lactobacillus rhamnosus GG DNA containing novel oligodeoxynucleotide pattern
      Cellular Microbiology, 7, 403-414, 2005.
  • 2004
    • 5. Shimosato, T., Kitazawa, H.*, Tohno, M., Katoh, S., Kawai, Y. & Saito, T.
      Development of immune assay system for both CpG and non-CpG DNA from lactic acid bacteria using a transfectant of swine Toll-like receptor 9
      Animal Science Journal, 75, 377-382, 2004.

      4. Sato, T., Nishimura-Uemura, J., Shimosato, T., Kawai, Y., Kitazawa, H. & Saito, T.*
      Dextran from Leuconostoc mesenteroides augments immunostimulatory effects by the introduction of phosphate groups
      Journal of Food Protection, 67, 1719-1724, 2004.

      3. Katoh, S., Kitazawa, H.*, Shimosato, T., Tohno, M., Kawai, Y. & Saito, T.
      Cloning and characterization of swine interleukin-17, preferentially expressed in the intestines
      Journal of Interferon and Cytokine Research, 24, 553-559, 2004.
  • 2003
    • 2. Shimosato, T., Kitazawa, H.*, Katoh, S., Tomioka, Y., Karima, R., Ueha, S., Kawai, Y., Hishinuma, T., Matsushima, K. & Saito, T.
      Swine Toll-like receptor 9 recognizes CpG motifs of human cell stimulant
      Biochimica et Biophysica Acta-Gene Structure and Expression, 1627, 56-61, 2003.

      1. Kitazawa, H.*, Watanabe, H., Shimosato, T., Kawai, Y., Itoh, T. & Saito, T.
      Immunostimulatory oligonucleotide, CpG-like motif exists in Lactobacillus delbrueckii ssp bulgaricus NIAI B6
      International Journal of Food Microbiology, 85, 11-21, 2003.