Shinshu Univesity                           日本語/ENGLISH                                                                   

Food Chemistry Laboratory

Food Chemistry Lab in the Fuculty of Agriculture at Shinshu University has a number of graduate student positions and invites high quality students to apply.
Applications will be considered twice each year on summer and winter.

Applicants should send a hard copy of their Curriculum Vitae, a full academic transcript and covering letter indicating their research interests and if the application is for Master or PhD position by e-mail at:

We welcome motivated international studensts. International graduate sutudents from Tanzania and Bangladesh have already got a doctor's degree. Please don't hesitate to conctact us.

A list of prospective projects

001. Functionality of food-derived bioactive compounds.

002. Improvement of functionalities of bioactive compounds by glycosylation, phospholylation, and lipophilization.

003. Structure-function relationship of bioactive compounds.


 Professor  Dr. Shigeru Katayama
 Assistant Professor  Dr. Kihhou Tei

 D3    Ikuya Shirai
Fawaz Bagoudou (from Benin)
 D1 Takafumi Kanda
 M2    Yuriko Kamijo
Hiroki Kawabata
Yusuke Kodaira
Chizuru Okahata
Mayu Yasuda
 M1   Emiri Koike
Sota Fukue
Nozomi Moriya
Mizuki Yamao
 B4   Ko Eun Kyong (from Korea)
Masanobu Takahashi
Rio Yamazaki
 Technician Izumi Matsuno

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Fermented rice peptides attenuate scopolamine-induced memory impairment in mice by regulating neurotrophic signaling pathways in the hippocampus
Brain Research,1720:146322 2019(Oct.)
Author:H.M.Corpuz, H. Fujii, S. Nakamura, S. Katayama

Long-term intake of glucoraphanin-enriched kale suppresses skin aging via activating Nrf2 and the TβRII/Smad pathway in SAMP1 mice
Journal of Agricultural and Food Chemistry 2019(Aug. 08)
Author:Supatta Chawalitpong, Saki Ichikawa, Yuki Uchibori, Soichiro Nakamura, Shigeru Katayama

Enhanced anti-allergic activity of milk casein phosphopeptide by additional phosphorylation in ovalbumin-sensitized mice
Molecules,24:738 2019(Feb. 19)
Author:Ntshepisa Lebetwa, Yuta Suzuki, Sachi Tanaka, Soichiro Nakamura, Shigeru Katayama *

Adzuki bean (Vigna angularis) extract reduces amyloid- beta aggregation and delays cognitive impairment in Drosophila models of Alzheimer's disease
Nutrition Research And Practice,13(1):64-69 2019(Feb.)
Author:Miyazaki, H; Okamoto, Y; Motoi, A; Watanabe, T; Katayama, S; Kawahara, S; Makabe, H; Fujii, H; Yonekura, S

Emerging roles of bioactive peptides on brain health promotion
International Journal of Food Science & Technology,54(6):1949-1955 2019
Author:S. Katayama and S. Nakamura

Preparation of an allergen-specific immunomodulator by phosphorylation of a major buckwheat globulin allergen, Fag e 1, with diminished IgE response via Tfh cell activation
Japanese Journal of Food Chemistry and Safety 2019
Author:Ahmad M. Al Athamneh, Supatta Chawalitpong, Yuta Suzuki, Daiki Yamaguchi, Soichiro Nakamura, Shigeru Katayama

Biological and neuroprotective activity of some Thai edible plant extracts
Industrial Crops and Products,124:548-554 2018(Nov.)
Author:P. Junsathian, K. Yordtong, S. Katayama, H.M. Corpuz, S. Nakamura, S. Rawdkuen

Long-term diet supplementation with Lactobacillus paracasei K71 prevents age-related cognitive decline in senescence-accelerated mouse prone 8
Nutrients,10(6):E762 2018(Jun.)
Author:Henry M. Corpuz, Saki Ichikawa, Misa Arimura, Toshihiro Mihara, Takehisa Kumagai, Takakazu Mitani, Soichiro Nakamura, Shigeru Katayama*

Cyperenoic acid suppresses osteoclast differentiation and delays bone loss in a senile osteoporosis mouse model by inhibiting non-canonical NF-κB pathway
Scientific Reports,8:5625 2018
Author:S., Chawalitpong, R., Chokchaisiri, A., Suksamrarn, S., Katayama, T., Mitani, S., Nakamura, A., AI Athamneh, P., Ritprajak, A., Leelahavanichkul, R., Aeimlapa, N., Charoenphandhu, T., Palaga

Soybean-derived glycine-arginine dipeptide administration promotes neurotrophic factor expression in the mouse brain
Journal of Agricultural and Food Chemistry,66(30):7935-7941 2018
Author:Shimizu, A., Mitani, T., Tanaka, S., Fujii, H., Maebuchi, M., Amiya, Y., Tanaka, M., Matsui, T., Nakamura, S., Katayama, S.

Oral immunotherapy with a phosphorylated hypoallergenic allergen ameliorates allergic responses more effectively than intact allergen in a murine model of buckwheat allergy
Molecular Nutrition & Food Research,62(21):e1800303 2018
Author:S. Katayama, D. Yamaguchi, Y. Suzuki, A.M. Al Athamneh, T. Mitani, R. Satoh, R. Teshima, Y. Mine, S. Nakamura

Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes
Archives of Biochemistry and Biophysics,646:98-106 2018
Author:Mitani T, Takaya T, Harada N, Katayama S (corresponding author), Yamaji R, Nakamura S, Ashida H

Cyperenoic acid suppresses osteoclast differentiation and delays bone loss in a senile osteoporosis mouse model by inhibiting non-canonical NF-κB pathway
Scientific Reports,8:5625 2018
Author:S., Chawalitpong, R., Chokchaisiri, A., Suksamrarn, S., Katayama, T., Mitani, S., Nakamura, A., AI Athamneh, P., Ritprajak, A., Leelahavanichkul, R., Aeimlapa, N., Charoenphandhu, T., Palaga

Kale supplementation up-regulates HSP70 and suppresses cognitive decline in a mouse model of accelerated senescence
Journal of Functional Foods,44:292-298 2018
Author:Kushimoto, S. Uchibori, Y., Yanai, S., Makabe, H., Nakamura, S., Katayama, S.


Rutinosylated ferulic acid attenuates food allergic response and colitis by up-regulating regulatory T cells in mouse models
Journal of Agricultural and Food Chemistry,65(49):10730-10737 2017
Author:Katayama, S., Ohno, F., Mitani, T., Akiyama, H., Nakamura, S.

Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein degradation by adenosine receptor A1
BBA Molecular Cell Research,1864:2438-2448 2017
Author:Mitani T, Watanabe S, Yoshioka Y Katayama S, Nakamura S, Ashida H

Solventless extraction methods for immature fruits: Evaluation of their antioxidant and cytoprotective activities
Food Chemistry,221:1388-1393 2017
Author:MY Heng, S Katayama, T Mitania, ES Ong, S Nakamura

Role of phosphate groups on antiviral activity of casein phosphopeptide against feline calicivirus as a surrogate for norovirus
Journal of the Science of Food and Agriculture,97:1939-1944 2017
Author:Lebetwa, N., Mitani, T., Nakamura, S., Katayama, S.


Biophysical characterization of the domain association between cytosolic A and B domains of the mannitol transporter enzymes IIMtl in the presence and absence of a connecting linker
Protein Science,25(10):1803-1811 2016
Author:KO Lee, EH Kim, G Kim, JY Jung, S Katayama, S Nakamura, JY Suh

Intestinal immunomodulatory effects of a hypoallergenic buckwheat Fag e 1 prepared by Maillard-type glycation with a mannan type-polysaccharide
Japanese Journal of Food Chemistry and Safety,23(2):72-79 2016
Author:Katayama, S., Tazawa, S., Kassai, M., Mitani, T., Nakamura, S.

Effects of sesaminol feeding on brain Aβ accumulation in a senescence-accelerated mouse-prone 8
Journal of Agricultural and Food Chemistry,64(24):4908-4913 2016
Author:Katayama, S., Sugiyama, H., Kushimoto, S., Uchiyama, Y., Hirano, M., Nakamura, S.


Antioxidant and cytoprotective activities of extracts prepared from fruit and vegetable wastes and by-products
Food Chemistry,167:358-362 2015
Author:Faisal Kabir, Wei Wei Tow, Yasunori Hamauzu, Shigeru Katayama, Sachi Tanaka, Soichiro Nakamura

Attenuation of Allergic Immune Response Phenotype by Mannosylated Egg White in Orally Induced Allergy in Balb/c Mice
J. Agric. Food Chem.,62:9479-9487 2014
Author:Prithy Rupa, Soichiro Nakamura, Shigeru Katayama, Yoshinori Mine

Improvement of surface functionalities, including allergenicity attenuation, of whole buckwheat protein fraction by Maillard-type glycation with dextran
Prev. Nutr. Food Sci.,19:327-332 2014
Author:Shigeru Tazawa, Shigeru Katayama, Masahiro Hirabayashi, Daiki Yamaguchi, Soichiro Nakamura

Antimicrobial effects of chlorogenic acid and related compounds
Appl Biol Chem,57:359−365 2014
Author:Faisal Kabir, Shigeru Katayama, Noriko Tanji,Soichiro Nakamura

Oral administration of soy peptides suppresses cognitive decline by induction of neurotrophic factors in SAMP8 mice
J. Agric. Food Chem.,62:3563-3569 2014
Author:Shigeru Katayama, Rie Imai,Haruka Sugiyama, Soichiro Nakamura

Changes in mouse gastrointestinal microbial ecology with the ingestion of kale
Beneficial Microbes,5:345-350 2014
Author:Yutaka Uyeno, Shigeru Katayama, Soichiro Nakamura

Enhanced anti-amyloidal activity of hydroxy cinnamic acids by enzymatic esterification with alkyl alcohols
Biotechnology and Applied Biochemistry,61:401-407 2014
Author:Kondo, H., Katayama, S., Sugiyama, H., Nakamura, S.

Effects of ovalbumin glycoconjugates on alleviation of arally induced egg allergy in mice via dendritic-cell maturation and T-cell activation
Molecular Nutrition&Food Research (IF=4.31),58:405-417 2014
Author:Prithy Rupa, Soichiro Nakamura, Shigeru Katayama, Yoshinori Mine

Prevention of allergic disease development and symptoms by food factors.
Current Pharmaceutical Design (CPD),20:892-905 2014
Author:Hiroshi Akiyama, Shigeru Katayama, Tomomasa Kanda, Mari Maeda-Yamamoto, Mamoru Totsuka, Shingo Takahashi, Toshihiko Shoji, Takahiro Inakuma, Soichiro Nakamura

Enzymatic synthesis of novel phenol acid rutinosides using rutinase and their antiviral activity in vitro
J. Agric. Food Chem.,61:9617-9622 2013
Author:Shigeru Katayama, Fumiaki Ohno, Yuki Yamauchi, Miyuki Kato, Hidefumi Makabe, Soichiro Nakamura

Functional expression of amyloidogenic human stefins A and B in Pichia pastoris
Biotechnology and Applied Biochemistry,60:283-288 2013
Author:Kosuke Nakamura, Yuki Maeda, Kensuke Morimoto, Shigeru Katayama, Kondo Kazunari, Soichiro Nakamura

Apple polyphenols suppress antigen presentation of ovalbumin by THP-1-derived dendritic cells.
Food Chemistry,138:757-761 2013
Author:Shigeru Katayama; Takuya Kukita; Eri Ishikawa; Syohei Nakashima; Susumu Masuda; Tomomasa Kanda; Hiroshi Akiyama; Reiko Teshima; Soichiro Nakamura

Analysis of Mechanisms of Induction of an Insulin-Inducible TranscriptionFactor, SHARP-2, by (-)-Epigallocatechin-3-gallate.
Journal of Agricultural and Food Chemistry,60:9850−9855 2012
Author:Ayumi Haneishi, Katsuhiro Takagi, Kosuke Asano, Soichiro Nakamura, and Kazuya Yamada

(-)-Epigallocatechin-3-gallate stimulates both AMP-activated protein kinase and nuclear factor-kappa B signaling pathways
Food Chemistry (IF=3.922),134:783-788 2012
Author:Kosuke Asano, Katsuhiro Takagi, Ayumi Haneishi, Soichiro Nakamura, Kazuya Yamada

Improving surface functional properties of Tofu whey-derived peptidesby chemical modification with fatty acids
J. Food Sci. (IF=2.059),77(4):C333-C339 2012
Author:Matemu, A.O., Nakamura, K., Kayahara, H., Murasawa, H., Katayama, S. and Nakamura, S.

Immunomodulatory Properties of Highly Viscous Polysaccharide Extract from the Gagome Alga (Kjellmaniella crassifolia)
Plant Foods for Human Nutrition,67(1):76-81 2012
Author:Katayama, S., Nishio, T., Kishimura, H., Saeki, H.

A trypsin inhibitor in the viscera of Japanese common squid (Todarodes pacificus) elicits insulinotropic effects in diabetic GK rats
Journal of Food Biochemistry,36(1):93-98 2012
Author:Kishimura, H., Fukumorita, K., Adachi, K., Chiba, S., Nagai, Y., Katayama, S., Nakajima, S., Saeki, H.

Apricot carotenoids possess potent anti-amyloidogenic activity in vitro
J. Agric. Food Chem. (IF=3.209),59:12691-12696 2011
Author:Katayama, Shigeru; Ogawa, Hirofumi; Nakamura, Soichiro

(-)-Epigallocatechin-3-Gallate Enhances the Expression of an Insulin-Inducible Transcription Factor Gene via a Phosphoinositide 3-Kinase/ Atypical Protein Kinase C Lambda Pathway
J. Agric. Food Chem. (IF=3.209),59:13360-13364 2011
Author:Asano, Kosuke; Takagi, Katsuhiro; Haneishi, Ayumi; Yamamoto, Taichi; Tanaka, Takashi; Noguchi, Tamio; Nakamura, Soichiro; Yamada, Kazuya

Improved emulsifying properties of soy proteinsby lipophilization with saturated fatty acids
Food Chemistry (IF=3.922),124:596-602 2011
Author:Matemu, A.O., Katayama, S., and Nakamura, S.

Enhanced antiviral activity of soybean β-conglycinin-derived peptides by acylation with saturated fattyacids
J. Food Sci.(IF=2.059),76:299-304 2011
Author:Athanasia O. Matemu, Kosuke Nakamura, Hisataka Kayahara, Hisashi Murasawa, Shigeru Katayama, Soichiro Nakamura

Genistein stimulates the insulin-dependent signaling pathway
Frontiers in Bioscience-Landmark (IF=4.048),3:1534-1540 2011
Author:Ayumi Haneishi, Katsuhiro Takagi, Kosuke Asano, Soichiro Nakamura, Norio Kagawa, Kazuya Yamada

Changes in solubility and thermal stability of chicken myofibrillar protein by glycosylation
Food Science and Technology Research,17(1):69-75 2011
Author:Nishimura, K., Murakoshi, M., Katayama, S., Saeki, H.

Antioxidative Ability in Chicken Myofibrillar Protein developed by Glycosylation and Changes in the Solubility and Thermal Stability
Bioscience, Biotechnology, and Biochemistry,75(2):247-254 2011
Author:Nishimura, K., Murakoshi, M., Katayama, S., Saeki, H

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